Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma

Cancer Biotherapy and Radiopharmaceuticals

Volumn 12, Issue 3, 1997, Pages 167-175

  Juang, Shin Hun ^a   Xie, Keping ^a   Xu, Leu ^a   Wang, Yunfang ^a   Yoneda, Junya ^a   Fidler, Isaiah J ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cytotoxicity; iNOS; Packaging cells; Retrovirus

Indexed keywords

NITRIC OXIDE SYNTHASE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CYTOTOXICITY; ENZYME INDUCTION; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSDUCTION; LUNG METASTASIS; MALE; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

EID: 0030750221     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.1997.12.167     Document Type: Article

References (41)

1. Nathan C, Xie Q-W. Regulation of the biosynthesis of nitric oxide. J Biol Chem 1994;269:13725-13728.
2. Nathan C. Nitric oxide as a secretive product of mammalian cells. FASEB J 1992;6:3051-3064.
3. Nathan C, Xie Q-W Nitric oxide synthases: roles, tolls, and control. Cell 1994;78:915-919.
4. Xie K, Dong Z, Fidler IJ. Activation of nitric oxide synthase gene for inhibition of cancer metastasis. J Leukoc Biol 1996;59:797-803.
5. Sakkoula E, Haralabopoulos G, Andriopoulou P, Peristeris P, Maragoudakis ME. Evidence that nitric oxide is an endogenous and antiangiogenic mediator. Br J Pharmacol 1994;111:894-902.
6. Palmer RMJ, Rees DD, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine Nature 1988;333:664-666.
7. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1990;84:9265-9269
8. Radomski MW, Palmer RMJ, Monicasa S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990;87:5193-5197.
9. Radomski MW, Palmer RMJ, Monicasa S. Characterization of the L-arginine: nitric oxide pathway in human platelets. Br J Pharmacol 1990;101:325-328.
10. Fidler IJ. Critical factors in the biology of human cancer metastasis. Cancer Res 1990;50:6130-6138.
11. Suginoto Y, Oh-hara T, Watanabe M, Uamori T, Tsuruo T. Acquisition of metastatic ability in hybridomas between two low metastatic clones of murine colon adenocarcinoma 26 defective in either platelet-aggregation activity or in vivo growth potential. Cancer Res 1987;47:3115-3117.
12. Tsuruo T, Kawabata H, Iida H, Yomori T. Tumor-induced platelet aggregation and growth-promoting factors as determinants for successful tumor metastasis. Clin Exp Metastasis 1986;7:25-33.
13. Stuehr DJ, Nathan CF. Nitric oxide, a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells J Exp Med 1989;169:1543-1555.
14. Stuehr DJ, Griffith OW. Mammalian nitric oxide synthase. In: Advances in Enzymology and Related Areas of Molecular Biology, Meister A (ed), vol 165 Interscience, New York, 1992:287-346.
15. Hibbs HB Jr, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-arginine deaminase activity and amino nitrogen to nitrate. Science 1987;235:473-476.
16. Xie K, Huang S, Dong Z, Gutman M, Fidler IJ. Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362. Cancer Res 1995;55:3123-3131.
17. Li L, Kilbourn RG, Adams J, Fidler IJ. Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res 1989,51:2531-2535.
18. Lorsbach RB, Murphy WJ, Lowenstein CJ, Snyder SH, Russell SW. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem 1993;268:1908-1913.
19. Sheffler LA, Wink DA, Melillo G, Cox GW. Exogenous nitric oxide regulated IFN-γ plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages. J Immunol 1995;155:886-894
20. Dong Z, Staroselsky AH, Qi X, Xie K, Fidler IJ. Inverse correlation between expression of inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine cells. J Exp Med 1995;181:1333-1343.
21. Xie K, Huang S, Dong Z, Juang S-H, Gutman M, Xie Q-W, Nathan C, Fidler IJ. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine cells. J Exp Med 1995;181:1333-1343.
22. Xie K, Huang S, Dong Z, Juang S-H, Wang Y, Fidler IJ. Destruction of bystander cells by tumor cells transfected with the inducible nitric oxide synthase gene. J Natl Cancer Inst 1997;89:421-427.
23. Kripke ML. Speculations on the role of ultraviolet radiation in the development of malignant melanoma. J Natl Cancer Inst 1979;63:541-545.
24. Fidler IJ, Gruys E, Cifone MA, Barnes Z, Bucana CD. Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin. J Natl Cancer Inst 1981;67:947-956.
25. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989;7:980-990.
26. Xie Q-W, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 1992;256:225-228.
27. Xie Q-W, Cho H, Kashiwabara Y, Baum M, Weidner JR, Ellison K, Mumford R, Nathan C. Carboxyl terminus of inducible nitric oxide synthase: contribution to NADPH binding an enzymatic activity. J Biol Chem 1994;269:28500-28509.
28. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977;74:5463-5467.
29. Miller AD. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 1986;6:2895-2902.
30. Fan D, Bucana CD, O'Brian CA, Zwelling LA, Seid C, Fidler D. Enhancement of tumor cell sensitivity to adriamycin by presentation of the drug in phosphatidylcholine and phosphatidylserine liposomes. Cancer Res 1990;50:3619-3626.
31. Li L, Price JE, Fan D, Zhang R, Bucana CD, Fidler IJ. Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites. J Natl Cancer Inst 1989;81:1406-1412.
32. Ding A, Nathan C, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J Immunol 1988;141:2047-2054.
33. Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 1975;98:503-517.
34. Field AK, Davies ME, DeWitt C, Perry HC, Liou R, Gemershausen J, Karkas JD, Ashton WT, Johnston DB, Tolman RL. 9-([2-Hydroxy-1-hydroxy-methyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci USA 1983;80:4139-4143.
35. Molten FL, Wells JM. Curability of tumors bearing herpes thymidine kinase genes transferred by retrovirus vector J Natl Cancer Inst 1990;82:297-300.
36. Culver KW, Ram Z, Wawbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992;256:1550-1552.
37. Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL, Abraham GN. The bystander effect tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993;53:5274-5283.
38. Freeman SM, Whartenby KA, Koeplin DS, Moolten FL, Abboud CN, Abraham GN. Tumor regression when a fraction of tumor mass contains the HSV-TK gene. J Cell Biochem 1992;16F:47.
39. Savill J, Dransfield I, Hogg N, Haslett C. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 1990;343:170-173.
40. Miller FR, McEachern D, Miller BE Efficiency of communication between tumor cells in collagen gel cultures. Br J Cancer 1990;62.360-363.
41. Karupiah G, Xie Q-W, Buller RM, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science 1993;261:1445-1448.