An assessment of rat photoreceptor sensitivity to mitochondrial blockade

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 8, 1997, Pages 1569-1577

  Winkler, Barry S ^a   Dang, Loan ^a   Malinoski, Celeste ^b   Easter Jr , Stephen S ^b  

^a OAKLAND UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Energy metabolism; Mitochondria; Photoreceptor cells; Rat retina; Receptor potential

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; BICARBONATE; POTASSIUM CYANIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DARK ADAPTATION; ELECTRON MICROSCOPY; GLYCOLYSIS; MEMBRANE BINDING; MITOCHONDRIAL MEMBRANE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RAT; RECEPTOR POTENTIAL; RECEPTOR SENSITIVITY; RETINA ROD;

ADENOSINE TRIPHOSPHATE; ANAEROBIOSIS; ANIMALS; ANTIMYCIN A; DARK ADAPTATION; ELECTROPHYSIOLOGY; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MITOCHONDRIA; NITROGEN; OXYGEN; PHOTORECEPTORS; POTASSIUM CYANIDE; RATS; TIME FACTORS;

EID: 0030750197     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Sjostrand FS. The ultrastructure of the inner segments of the retinal rods of the guinea pig eye as revealed by electron microscopy. J Cell Comp Physiol. 1953;42: 45-70.
2. DeRobertis E. Electron microscope observations on the submicroscopic organization of the retinal rods. J Biophys Biochem Cytol. 1956;2:319-329.
3. Cohen AI. New evidence supporting the linkage to extracellular space of outer segment saccules of frog cones but not rods. J Cell Biol. 1968;37:724-744.
4. Dickson DH, Hollenberg MJ. The fine structure of the pigment epithelium and photoreceptor cells of the newt, triturus viridescens dorsalis (Rafinesque). J Morphol. 1971;135:389-432.
5. Stell WK. The structure and morphologic relations of rods and cones in the retina of the spiny dogfish, squalus. Comp Biochem Physiol. 1972;42A:141-151.
6. Witkovsky P, Shakib M, Ripps H. Interreceptoral junctions in the teleost retina. Invest Ophthalmol Vis Sci. 1974;13:996-1009.
7. Burnside B, Smith B, Nagata M, Porrello K. Reactivation of contraction in detergent-lysed teleost retinal cones. J Cell Biol. 1982;92:199-206.
8. Steinberg RH. Monitoring communications between photoreceptors and pigment epithelial cells: Effects of 'mild' systemic hypoxia. Invest Ophthalmol Vis Sci. 1987;28:1888-1903.
9. Townes-Anderson E, Dacheux RF, Raviola E, Rod photoreceptors dissociated from the adult rabbit retina. J Neurosci. 1988;8:320-331.
10. Cohen LH, Noell WK. Glucose catabolism of rabbit retina before and after development of visual function. J Neurochem. 1960;5:253-276.
11. Cohen LH, Noell WK. Relationships between visual function and metabolism. In: Graymore C, ed. Biochemistry of the Retina. London: Academic Press; 1965:36-50.
12. Zuckerman R, Weiter JJ. Oxygen transport in the bull-frog retina. Exp Eye Res. 1980;30:117-127.
13. Winkler BS. Glycolytic and oxidative metabolism in relation to retinal function. J Gen Physiol. 1981;77:667-692.
14. Winkler BS. The intermediary metabolism of the retina. Biochemical and functional effects. In: Anderson RE, ed. Biochemistry of the Eye. San Francisco: American Academy of Ophthalmology; 1983:227-242.
15. Linsenmeier RA. Effects of light and darkness on oxygen distribution and consumption in the cat retina. J Gen Physiol. 1986;88:521-542.
16. Alder VA, Cringle SJ, Cornstable IJ. The retinal oxygen profile in cats. Invest Ophthalmol Vis Sci. 1987;24:30-36.
17. Haugh-Scheidt LM, Linsenmeier RA, Griff ER. Oxygen consumption in the isolated toad retina. Exp Eye Res. 1995;61:63-72.
18. Haugh-Scheidt LM, Griff ER, Linsenmeier RA. Light evoked oxygen responses in the toad retina. Exp Eye Res. 1995;61:73-81.
19. Medrano CJ, Fox DA. Oxygen consumption in the rat outer and inner retina: Light- and pharmacologically-induced inhibition. Exp Eye Res. 1995;61:273-284.
20. Winkler BS. A quantitative assessment of glucose metabolism in the rat retina. In: Christen Y, Doly M, Droy-Lefaix MT, eds. Vision and Adaptation, Les Seminaires Ophthalmologiques d'IPSEN. Vol. 6. Paris: Elsevier; 1995:78-96.
21. Ladman AJ. The fine structure of the rod bipolar synapse in the retina of the albino rat. J Biophys Biochem Cytol. 1958;4:459-466.
22. Nir I, Agarwal N, Papermaster DS. Opsin gene expression during early and late phases of retinal degeneration of rds mice. Exp Eye Res. 1990;51:257-267.
23. Dowling JE. Foveal receptors of the monkey retina: Fine structure. Science. 1965;147:57-59.
24. Rodieck RW. The Vertebrate Retina. Principles of Structure and Function. San Francisco: WH Freeman; 1973:408.
25. Hagins WA, Penn RD, Yoshikami S. Dark current and photocurrent in retinal rods. Biophys J. 1970;10:380-402.
26. Hagins WA. The visual process: Excitatory mechanisms in the primary photoreceptor cells. Ann Rev Biophys Bioenerg. 1972;1:131-154.
27. Hagins WA, Yoshikami S. Ionic mechanisms in excitation of photoreceptors. Ann NY Acad Sci. 1975;264: 314-325.
28. Winkler BS. Relative inhibitory effects of ATP depletion, ouabain and calcium on retinal photoreceptors. Exp Eye Res. 1983;36:581-594.
29. Stirling CE, Lee A. Ouabain autoradiography of frog retina. J Cell Biol. 1980;85:313-324.
30. Noell WK. Electrophysiologic study of the retina during metabolic impairment. Am J Ophthalmol. 1952;35: 126-133.
31. Noell WK. The visual cell: Electric and metabolic manifestation of its life processes. Am J Physiol. 1959;48: 347-370.
32. Winkler BS. The eletroretinogram of the isolated rat retina. Vision Res. 1972;12:1183-1198.
33. Winkler BS. Buffer dependence of retinal glycolysis and ERG potentials. Exp Eye Res. 1986;42:585-593.
34. Lopez-Escalera R, Li X-B, Szerencsei RT, Schnetkamp PPM. Glycolysis and glucose uptake in intact outer segments isolated from bovine retinal rods. Biochemistry. 1991;30:8970-8976.
35. Hsu S-C, Molday RS. Glycolytic enzymes and a GLUT-1 glucose transporter in the outer segments of rod and cone photoreceptor cells. J Biol Chem. 1991;266: 21745-21752.
36. Hsu S-C, Molday RS. Glucose metabolism in photoreceptor outer segments. J Biol Chem. 1994;269:17954-17959.
37. Rowe MP, Engheta N, Easter SS Jr, Pugh EN Jr. Graded-index model of a fish double cone exhibits differential polarization sensitivity. J Opt Soc Am A. 1994;11:55-70.
38. 2 supply in hepatocytes. Am J Physiol 1984;247:C83-C89.
39. 2 and ATP. Am J Physiol 1986;250 (Cell Physiol. 19):C663-C675.
40. Linsenmeier RA. Electrophysiological consequences of retinal hypoxia. Graefes Arch Clin Exp Ophthalmol 1990;228:143-150.
41. Demant E, Nagahara K, Niemeyer G. Effects of changes in systemic blood pressure on the electroretinogram of the cat: Evidence for retinal autoregulation. Invest Ophthalmol Vis Sci. 1982;23:683-687.
42. Barnett NL, Osborne NN. Prolonged bilateral carotid artery occlusion induces electrophysiological and immunohistochemical changes to the rat retina without causing histological damage. Exp Eye Res. 1995;61:83-90.
43. Yamamoto F, Borgula GA, Steinberg RH. Effects of light and darkness on pH outside rod photoreceptors in the cat retina. Exp Eye Res. 1992;54:685-697.
44. Yamamoto F, Steinberg RH. Effects of systemic hypoxia on pH outside rod photoreceptors in the cat retina. Exp Eye Res. 1992;54:699-709.
45. Penn RD, Hagins WA. Signal transmission along retinal rods and the origin of the electroretinographic a-wave. Nature. 1969;223:201-205.
46. Winkler BS, Arnold MJ, Brassell MA, Sliter DR. Glucose dependence of glycolysis, hexose monophosphate shunt activity, energy status, and the polyol pathway in retinas isolated from normal (nondiabetic) rats. Invest Ophthalmol Vis Sci. 1997;38:62-71.
47. Fliesler SJ, Richards MJ, Miller C-Y, McKay S, Winkler BS. In vitro metabolic competence of the frog retina: Effects of glucose and oxygen deprivation. Exp Eye Res. 1997; in press.