Desensitization shortens the high-quantal-content endplate current time course in frog muscle with intact cholinesterase

Journal of Physiology

Volumn 502, Issue 3, 1997, Pages 641-648

  Giniatullin, R A ^a,b   Talantova, M ^a,b   Vyskocil F ^c  

^a KAZAN STATE MEDICAL UNIVERSITY   (Russian Federation)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CARBACHOL; NEOSTIGMINE; POSTSYNAPTIC RECEPTOR; PROADIFEN; CHOLINESTERASE;

ANIMAL TISSUE; ARTICLE; DESENSITIZATION; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SARTORIUS MUSCLE; ACTION POTENTIAL AMPLITUDE; ANURA; CONTROLLED STUDY; ENDPLATE CURRENT; MUSCLE POTENTIAL; NERVOUS SYSTEM ELECTROPHYSIOLOGY;

ACETYLCHOLINE; ANIMALS; CARBACHOL; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; MEMBRANE POTENTIALS; MOTOR ENDPLATE; MUSCLE, SKELETAL; NEOSTIGMINE; NICOTINIC AGONISTS; PROADIFEN; RANA RIDIBUNDA; RECEPTORS, CHOLINERGIC; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 0030749899     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.641bj.x     Document Type: Article

References (31)

1. ANDERSON, C. R. & STEVENS, C. F. (1973). Voltage-clamp analysis of acetylcholine induced end-plate current fluctuation at frog neuromuscular junction. Journal of Physiology 235, 655-691.
2. BARSTAD, J. A. B. & LILLEHEIL, G. (1968). Transversely cut diaphragm preparation from rat. An adjuvant tool in the study of the physiology and pharmacology of the myoneural junction. Archives Internationales de Pharmacodynamie et de Thérapie 175, 373-390.
3. BARTOL, M. T. JR, LAND, B. R., SALPETER, E. E. & SALPETER, M. M. (1991). Monte-Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction. Biophysical Journal 59, 1290-1307.
4. CACHELIN, A. B. & COLQUHOUN, D. (1989). Desensitization of the acetylcholine receptor of frog end-plates measured in a Vaseline-gap voltage clamp. Journal of Physiology 415, 159-188.
5. CIANI, S. & EDWARDS, C. (1963). The effect of acetylcholine on neuromuscular transmission in the frog. Journal of Pharmacology and Experimental Therapeutics 142, 21-29.
6. COHEN, J. B. & STRNAD, N. P. (1987). Permeability control and desensitization by nicotinic acetylcholine receptors. In Molecular Mechanisms of Desensitization to Signal Molecules, ed. KONJIN, T. M., VAN DE STARRE, H., VAN DER WEL, H. & HOUSLAY, M. D., pp. 257-273. Springer-Verlag, Berlin & Heidelberg.
7. DEL CASTILLO, J. & KATZ, B. (1954a). Quantal component of the end-plate potential. Journal of Physiology 124, 560-573.
8. DEL CASTILLO, J. & KATZ, B. (1954b). Statistical factors involved in neuromuscular facilitation and depression. Journal of Physiology 124, 574-585.
9. FELTZ, A. & TRAUTMANN, A. (1982). Desensitization at the frog neuromuscular junction: a biphasic process. Journal of Physiology 322, 257-272.
10. GINIATULLIN, R. A., BALTZER, S. K., NIKOLSKY, E. E. & MAGAZANIK, L. G. (1986). Postsynaptic potentiation and desensitization at frog neuromuscular junction induced by repetitive stimulation of the motor nerve. Neurofiziologia 18, 645-1354 (in Russian).
11. GINIATULLIN, R. A., KHAMITOV, K. H. S., KHAZIPOV, R., MAGAZANIK, L. G., NIKOLSKY, E. E., SNETKOV, V. A. & VYSKOČIL, F. (1989). Development of desensitization during repetitive end-plate activity and single end-plate currents in frog muscle. Journal of Physiology 412, 113-122.
12. GINIATULLIN, R. A., KHAZIPOV, R. N. & VYSKOČIL, F. (1993a). A correlation between quantal content and decay time of endplate currents in frog muscles with intact cholinesterase. Journal of Physiology 466, 95-103.
13. GINIATULLIN, R. A., KHAZIPOV, R. N., ORANSKA, T. I., NIKOLSKY, E. E., VORONIN, V. A. & VYSKOČIL, F. (1993b). The effect of nonquantal acetylcholine release on quantal miniature currents at mouse diaphragm. Journal of Physiology 466, 105-114.
14. HARTZELL, H. C., KUFFLER, S. W. & YOSHIKAMI, D. (1975). Postsynaptic potentiation: Interaction between quanta of acetylcholine at the skeletal neuromuscular synapse. Journal of Physiology 251, 427-463.
15. HEIDMANN, T. & CHANGEUX, J.-P. (1979). Fast kinetic studies on the interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata. European Journal of Biochemistry 94, 255-279.
16. KATZ, B. & MILEDI, R. (1973). The binding of acetylcholine to receptor and its removal from the synaptic cleft. Journal of Physiology 231, 549-574.
17. KATZ, B. & THESLEFF, S. (1957). A study of the 'desensitization' produced by acetylcholine at the motor end-plate. Journal of Physiology 138, 63-80.
18. MAGAZANIK, L. G., NIKOLSKY, E. E. & VYSKOČIL, F. (1982). Effect of the desensitization-potentiating agent SKF-525A on frog end-plate currents. European Journal of Pharmacology 80, 115-119.
19. MAGAZANIK, L. G., SNETKOV, V. A., GINIATULLIN, R. A. & KHAZIPOV, R. N. (1990). Changes in the time-course of miniature end-plate currents, induced by bath applied acetylcholine. Neuroscience Letters 113, 281-285.
20. MAGAZANIK, L. G. & VYSKOČIL, F. (1970). Dependence of acetylcholine desensitization on the membrane potential of frog muscle fiber and on the ionic changes in the medium. Journal of Physiology 210, 507-518.
21. MAGAZANIK, L. G. & VYSKOČIL, F. (1975). The effect of temperature on desensitization kinetics at the post-synaptic membrane of the frog muscle fibre. Journal of Physiology 249, 285-300.
22. MAGLEBY, K. L. & PALOTTA, B. S. (1981). A study of desensitization of ACh receptors using nerve-released transmitters in the frog. Journal of Physiology 316, 225-250.
23. NYSTROM, B. (1968). Histochemical studies of endplate bound esterases in slow-red and fast-white cat muscles during postnatal development. Acta Neurologica Scandinavica 44, 363-368.
24. PENNEFATHER, P. & QUASTEL, D. M. J. (1981). Relation between subsynaptic receptor blockage and responses to quantal transmitter at the mouse neuromuscular junction. Journal of General Physiology 78, 313-344.
25. SAKMANN, B. & WITZEMANN, V. (1989). Differential expression of receptor subunits: a mechanism underlying developmental changes in synaptic transmission. In Neuromuscular Junction, ed. SELLIN, L. C., LIBELIUS, R. & THESLEFF, S. Elsevier, Amsterdam.
26. SUGYIAMA, H., POPOT, J.-L. & CHANGEAUX, J.-P. (1976). Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. Journal of Molecular Biology 106, 485-496.
27. TAKEUCHI, A. & TAKEUCHI, N. (1959). Active phase of frog's end-plate potential. Journal of Neurophysiology 22, 395-411.
28. VOLKOVA, I. N., NIKOLSKY, E. E. & POLETAEV, G. I. (1975). Blockade of action potential and contraction of frog skeletal muscle by transverse cutting. Fiziologiceski Zhournal SSSR 61, 1433-1436 (in Russian).
29. VYSKOČIL, F., NIKOLSKY, E. E. & EDWARDS, C. (1983). An analysis of the non-quantal release of acetylcholine at the mouse neuromuscular junction. Neuroscience 9, 429-435.
30. VYSKOČIL, F. & VRBOVÁ, G. (1993). Role of non-quantal release of acetylcholine on neuromuscular junction of developing rat muscles. European Journal of Neuroscience 5, 1677-1683.
31. ZELENÁ, J. (1962). The effect of denervation on muscle development. In The Denervated Muscle, ed. GUTMANN, E., pp. 103-126. Czechoslovak Academy of Sciences, Publishing House, Prague.