Are the pharmacokinetics of ibuprofen important determinants for the drug's efficacy in postoperative pain after third molar surgery?

British Journal of Oral and Maxillofacial Surgery

Volumn 35, Issue 3, 1997, Pages 173-176

  Jones, K ^a   Seymour, R A ^b   Hawkesford, J E ^c  

^a DERBYSHIRE ROYAL INFIRMARY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DENTAL SURGERY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; HUMAN; ORAL DRUG ADMINISTRATION; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL;

EID: 0030749421     PISSN: 02664356     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0266-4356(97)90558-1     Document Type: Article

References (28)

1. Seymour RA, Walton JG. Pain control after third molar surgery. Int J Oral Surg 1984; 13: 457-485.
2. Meechan JG, Seymour RA. The use of third molar surgery in clinical pharmacology. Br J Oral Maxillofac Surg 1993; 31: 360-365.
3. Seymour RA, Hawkesford JE, Weldon M, Brewster D. An evaluation of different ibuprofen preparations in postoperative pain after third molar surgery. Br J Clin Pharmacol 1991; 31: 83-87.
4. Seymour RA, Ward-Booth P. An evaluation of different dosages and preparations of ibuprofen in postoperative dental pain. J Dent Res 1991; 70: 446.
5. Seymour RA, Rawlins MD. Pharmacokinetics of parenteral paracetamol in postoperative dental pain. Eur J Clin Pharmacol 1981; 20: 215-218.
6. Seymour RA, Rawlins MD. The efficacy and pharmacokinetics of aspirin in postoperative dental pain. Br J Clin Pharmacol 1982; 13: 807-810.
7. Seymour RA, Rawlins MD, Rowell FJ. Dihydrocodeine-induced hyperalgesia in postoperative dental pain. Lancet 1982; 1: 1425-1426.
8. Seymour RA, Williams FM, Ward A, Rawlins MD. Aspirin metabolism and analgesic efficacy in postoperative dental pain. Br J Clin Pharmacol 1984; 17: 697-701.
9. Matthews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Br Med J 1990; 300: 230-235.
10. Lasagna L. Analgesic methodology: a brief history and commentary. J Clin Pharmac 1980; 20: 373-400.
11. Gibaldi M, Perrier D. Pharmacokinetics. 1st ed. New York; Marcel Dekker, 1977.
12. Cooper SA. Five studies on ibuprofen for postsurgical dental pain. Am J Med 1984; 77: 70-77.
13. Frame JW, Evans CRH, Flaum GR, Langford R, Rout PGJ. A comparison of ibuprofen and dihydrocodeine in relieving pain following wisdom teeth removal. Br Dent J 1989; 166: 121-124.
14. Giles AD, Analgesia following dental surgery: a comparison of Brufen and Distalgesic. Br J Oral Surg 1981; 19: 105-111.
15. Hill CM, Carroll MJ, Giles AD, Pickvance N. Ibuprofen given pre- and post-operatively for the relief of pain. Int J Oral Maxillofac Surg 1978; 16: 420-424.
16. Jain AK, Ryan JR, McMahon FG, Kuebel JO, Walters PJ, Noveck C. Analgesic efficacy of low-dose ibuprofen in dental extraction pain. Pharmacotherapy 1987; 6: 318-322.
17. Rondeau PL, Yeung E, Nelson P. Dental surgery pain. J Canad Dent Assoc 1980; 7: 433-439.
18. Winter L, Bass E, Recant B, Cahaly JF. Analgesic activity of ibuprofen (Motrin) in postoperative oral surgical pain. Oral Surg 1978; 45: 159-167.
19. Seymour RA, Williams FM, Luyk NM, Boyle MA, Whitfield PM, Nicholson E, Ward-Booth PA, Rawlins MD. Comparative efficacy of soluble aspirin and aspirin tablets in postoperative dental pain. Eur J Clin Pharmacol 1986; 30: 495-498.
20. Holland IS, Seymour RA, Ward-Booth RP, Ord RA, Lim KLM, Hoare RC. An evaluation of different doses of soluble aspirin and aspirin tablets in postoperative dental pain. Br J Clin Pharmac 1988; 26: 463-468.
21. Laska EM, Sunshine A, Marrero I, Olso N, Siegel C, McCormick N. The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmac Therap 1986; 40: 1-7.
22. Grennan DW, Aarons L, Siddiqui M, Richards M, Thompson R, Higham C. Dose-response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic findings. Br J Clin Pharmacol 1983; 15: 311-316.
23. Lee EJD, Williams K, Day R, Graham G, Champion D. Stereoselective disposition of ibuprofen enantiomers in man. Br J Clin Pharmac 1985; 19: 669-674.
24. Geisslinger G, Schuster O, Stock K-P, Loew D, Bach GL, Brune K. Pharmacokinetics of S(+)- and R(-)- ibuprofen in volunteers and first clinical experience of S(+)- ibuprofen in rheumatoid arthritis. Eur J Clin Pharmacol 1990; 38: 493-497.
25. Adams SS, Bresloff P, Mason CG. Pharmacological differences between the optical isomers of ibuprofen; evidence for metabolic inversion of the (-)- isomer. J Pharm Pharmac 1976; 28: 256-257.
26. Gaut ZN, Baruth H, Randall LO, Ashley C, Paulsrud JR. Stereoisomeric relationship among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase. Prostaglandins 1975; 10: 59-66.
27. Evans AM, Nation RL, Sansom LN, Bochner F, Somogyi AA. Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)- ibuprofen. Br J Clin Pharmacol 1991; 31:131-138.
28. Bannworth B, Lipicque F, Pehourcq F. et al. Stereoselective disposition of ibuprofen enantiomers in human cerebrospinal fluid. Br J Clin Pharmacol 1995; 40: 266-269.