Deletion analysis at the Del-27, APC and MTS1 loci in bladder cancer: LOH at the Del-27 locus on 5p13-12 is a prognostic marker of tumor progression

International Journal of Cancer

Volumn 74, Issue 3, 1997, Pages 291-295

  Böhm, Malte ^a   Kirch, Heide ^a   Otto, Thomas ^a   Rübben, Herbert ^a   Wieland, Ilse ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANALYTIC METHOD; ARTICLE; BLADDER CANCER; CARCINOGENESIS; CYTOGENETICS; GENE DELETION; GENE FREQUENCY; GENE LOCATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROGNOSIS; TUMOR SUPPRESSOR GENE;

CARCINOMA, TRANSITIONAL CELL; DISEASE PROGRESSION; GENE DELETION; GENES, APC; GENES, TUMOR SUPPRESSOR; HUMANS; POLYMERASE CHAIN REACTION; URINARY BLADDER NEOPLASMS;

EID: 0030749364     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970620)74:3<291::AID-IJC10>3.0.CO;2-F     Document Type: Article

References (40)

1. ATKIN, N.B. and FOX, M.F., 5q deletion. The sole chromosome change in a carcinoma of the bladder. Cancer Genet. Cytogenet., 46, 129-131 (1990).
2. BABU, V.R., LUTZ, M.D., MILES, B.J., FARAH, R.N., WEISS, L. and VAN, DYKE, D.L., Tumor behaviour in transitional cell carcinoma of the bladder in relation to chromosomal markers and histopathology. Cancer Res., 47, 6800-6805 (1987).
3. BÖHM, M., TOTZECK, B., BIRCHMEIER, W. and WIELAND, I., Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer. Clin. Exp. Metastasis, 12, 55-62 (1994).
4. BÖHM, M. and WIELAND, I., Analysis of tumour-specific alterations in native specimens by PCR: how to procure the tumour cells! Int. J. Oncol., 10, 131-139 (1997).
5. BÖHM, M., WIELAND, I. and TOTZECK, B., Detection of tumor-specific homozygous deletions in human biopsies by polymerase chain reaction. Cancer Genet. Cytogenet., 65, 83-87 (1993).
6. CAIRNS. P., MAO, L., MERLO, A., LEE, D.J., SCHWAB, D., EBY, Y., TOKINO, K., VAN DER RIET, P., BLAUGRUND, J.E. and SIDRANSKY, D., Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science, 265, 415-416 (1994a).
7. CAIRNS, P. and 20 OTHERS, Frequency of homozygous deletion at p16/ CDKN2 in primary human tumours. Nature (Genet.), 11, 210-212 (1995).
8. CAIRNS, P., TOKINO, K., EBY, Y. and SIDRANSKY, D., Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction. Cancer Res., 54, 1422-1424 (1994b).
9. DALBAGNI, G., PRESTI, J., REUTER, V., FAIR, W.R. and CORDON-CARDO, C., Genetic alterations in bladder cancer. Lancet, 342, 469-471 (1993).
10. GIBAS, Z., PROUT, G.R., PONTES, J.E., CONNOLLY, J.G. and SANDBERG, A.A., A possible specific chromosome change in transitional cell carcinoma of the bladder. Cancer Genet. Cytogenet., 19, 229-238 (1986).
11. GIBAS, Z., PROUT, JR., G.R., CONNOLLY, J.G., PONTES, J.E. and SANDBERG, A.A., Nonrandom chromosomal changes in transitional cell carcinoma of the bladder. Cancer Res., 44, 1257-1264 (1984).
12. GREENWALD, B.D., HARPAZ, N., YIN, J., HUANG, Y., TONG, Y., BROWN, V.L., MCDANIEL, T., NEWKIRK, C., RESAU, J.H. and MELTZER, S.J., Loss of heterozygosity affecting the p53. Rb. and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer Res., 52, 741-745 (1992).
13. GRUIS, N.A. and 12 OTHERS, Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression. Amer. J. Pathol., 146, 1199-1206 (1995).
14. KAMB, A., GRUIS, N.A., WEAVER-FELDHAUS, J., LIU, Q., HARSHMAN, K., TAVTIGIAN, S.V., STOCKERT, E., DAY III, R.S., JOHNSON, B.E. and SKOLNICK, M.H., A cell cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436-440 (1994).
15. KEEN, A.J. and KNOWLES, M.A., Definition of two regions of deletion on chromosome 9 in carcinoma of the bladder. Oncogene, 9, 2083-2088 (1994).
16. KNOWLES, MA., Molecular genetics of bladder cancer. Brit. J. Urol., 75 (Suppl. 1), 57-66 (1995).
17. KNOWLES, M.A., ELDER, P.A., WILLIAMSON, M., CAIRNS, J.P., SHAW, M.E. and LAW, M.G., Allelotype of human bladder cancer. Cancer Res., 54, 531-538 (1994).
18. MOSTOFI, F.K., SOBIN, L.H. and TORLONI, H., Histological typing of urinary bladder tumours, World Health Organization, Geneva (1973).
19. NOBORI, T., MIURA, K., WU, D.J., LOIS, A., TAKABAYASHI, K. and CARSON, D.A., Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368, 753-756 (1994).
20. ORLOW, I., LIANES, P., LACOMBE, L., DALBAGNI, G., REUTER, V.E. and CORDON-CARDO, C., Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors. Cancer Res., 54, 2848-2851 (1994).
21. PACKENHAM, J.P., TAYLOR, J.A., ANNA, C.H., WHITE, C.M. and DEVEREUX, T.R., Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors. Mol. Carcinogenesis, 14, 147-151 (1995).
22. POWELL, I., TYRKUS, M. and KLEER, E., Apparent correlation of sex chromosome loss and disease course in urothelial cancer. Cancer Genet. Cytogenet., 50, 97-101 (1990).
23. SANDBERG, A.A. and BERGER, C.S., Review of chromosome studies in urological tumors. II. Cytogenetics and molecular genetics of bladder cancer. J. Urol., 151, 545-560 (1994).
24. SELTMANN, M., BÖHM, M., WALTER, T., SCHMITZ, G., PATTERSON, D. and WIELAND, I., Isolation of region-specific single-copy probes from human chromosome 1q23-1q25. Cytogenet. Cell Genet., 67, 46-51 (1994).
25. SPRUCK III, C.H., GONZALEZ-ZULUETA, M., SHIBATA, A., SIMONEAU, A.R., LIN, M.-F., GONZALES, F., TSAI, Y.C. and JONES, P.A., p16 gene in uncultured tumours. Nature (Lond.), 370, 183-184 (1994).
26. STADLER, W.M., SHERMAN, J., BOHLANDER, S.K., ROULSTON, D., DREYLING, M., RUKSTALIS, D. and OLOPADE, O.I., Homozygous deletions within chromosomal bands 9p21-22 in bladder cancer. Cancer Res., 54, 2060-2063 (1994).
27. STONE, S., JIANG, P., DAYANATH, P., TAVTIGIAN, S.V., KATCHER, H., PARRY, D., PETERS, G. and KAMB, A., Complex structure and regulation of the P16 (MTS1) locus. Cancer Res., 55, 2988-2994 (1995).
28. TYRKUS, M., POWELL, I. and FAKR, W., Cytogenetic studies of carcinoma in situ of the bladder: prognostic implications. J. Urol., 148, 44-46 (1992).
29. UCHIDA, T., WADA, C., ISHIDA, H., WANG, C., EGAWA, S., YOKOYAMA, E., KAMEYA, T. and KOSHIBA, K., p53 mutations and prognosis in bladder tumors. J. Urol., 153, 1097-1104 (1995).
30. UNION INTERNATIONALE CONTRE LE CANCER (UICC), TNM-Atlas, Springer, Berlin (1993).
31. VET, J.A.M., BRINGUIER, P.P., PODDIGHE, P.J., KARTHAUS, H.F.M., DE-BRUYNE, F.M.J. and SCHALKEN, J.A., p53 mutations have no additional prognostic value over stage in bladder cancer. Brit. J. Cancer, 70, 496-500 (1994).
32. VOGELSTEIN, B., FEARON, E.R., KERN, S.E., HAMILTON, S.R., PREISINGER, A.C., NAKAMURA, Y. and WHITE, R., Allelotype of colorectal carcinomas. Science, 244, 207-211 (1989).
33. VOORTER, C., JOOS, S., BRINGUIER, P.P., VALLINGA, M., PODDIGHE, P., SCHALKEN, J., DU-MANOIR, S., RAMAEKERS, F., LICHTER, P. and HOPMAN, A., Detection of chromosomal imbalances in transitional cell carcinoma of the bladder by comparative genomic hybridization. Amer. J. Pathol., 146, 11341-1354 (1995).
34. WIELAND, I., Isolation of a novel putative tumor suppressor gene on chromosome 5 in human lung cancer. Miami Bio/Technology Short Reports, 5, 26 (1994).
35. WIELAND, I., AMMERMÜLLER, T., BÖHM, M., TOTZECK, B. and RAJEWSKY, M.F., Microsatellite instability and loss of heterozygosity at the hMLH1 locus on chromosome 3p21 occur in a subset of non-small cell lung carcinomas. Oncol. Res., 8, 1-5 (1996a).
36. WIELAND, I. and BÖHM, M., Frequent allelic deletion at a novel locus on chromosome 5 in human lung cancer. Cancer Res., 54, 1772-1774 (1994).
37. WIELAND, I., BÖHM, M., ARDEN, K.C., AMMERMÜLLER, T., BOGATZ, S., VIARS, C.S. and RAJEWSKY, M.F., Allelic deletion mapping on chromosome 5 in human lung carcinomas. Oncogene, 12, 97-102 (1996b).
38. WIELAND, I., BÖHM, M. and BOGATZ, S., Isolation of DNA sequences deleted in lung cancer by genomic difference cloning. Proc. nat. Acad. Sci. (Wash.), 89, 9705-9709 (1992).
39. WU, S.Q., STORER, B.E., BOOKLAND, E.A., KLINGELHUTZ, A.J., GILCHRIST, K.W., MEISNER, L.F., OYASU, R. and REZNIKOFF, C.A., Non-random chromosome losses in stepwise neoplastic transformation in vitro of human uroepithelial cells. Cancer Res., 51, 3323-3326 (1991).
40. YOSHIMURA, I., KUDOH, J., SAITO, S., TAZAKI, H. and SHIMIZU, N., p53 gene mutation in recurrent superficial bladder cancer. J. Urol., 153, 1711-1715 (1995).