N,N-Dibenzyl formamidine as a new protective group for primary amines

Tetrahedron Letters

Volumn 38, Issue 43, 1997, Pages 7527-7530

  Vincent, Stéphane ^a   Mons, Stéphane ^a   Lebeau, Luc ^a   Mioskowski, Charles ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINE; AMINE; FORMAMIDINE;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030749249     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10023-5     Document Type: Article

References (17)

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2. Mons, S.; Lebeau, L.; Mioskowski, C. Unpublished results.
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14. Catalysts used in that work were of commercial origin (Acros).
15. a) Gauthier, J.A.; Miocque, M.; Combet-Farnoux, C. Preparation and synthetic uses of amidines. In The chemistry of functional groups: the chemistry of amidines and imidates; Patai, S. Ed.; Wiley: London, 1975; Vol. 1; pp. 1-84.
16. b) Boyd, G.V. Recent advances in the synthesis of amidines. In The chemistry of functional groups: the chemistry of amidines and imidates; Patai, S. and Rappoport, Z. Eds.; Wiley: Chichester, 1991; Vol. 2; pp. 339-366.
17. The reaction can be run in anhydrous DMF with a comparable yield and without any formation of N,N-dimethyl formamidine.