The gene for a T lymphocyte triggering factor from African trypanosomes

Journal of Experimental Medicine

Volumn 186, Issue 3, 1997, Pages 433-438

  Vaidya, Tushar ^a   Bakhiet, Moiz ^b   Hill, Kent L ^a   Olsson, Tomas ^b   Kristensson, Krister ^c   Donelson, John E ^a  

^a UNIVERSITY OF IOWA   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; GENE ISOLATION; IMMUNE RESPONSE; MOLECULAR INTERACTION; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; GENES, PROTOZOAN; HUMANS; INTERFERON INDUCERS; INTERFERON TYPE II; MICE; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0030749248     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.3.433     Document Type: Article

References (31)

1. Bakhiet, M., T. Olsson, P. Van der Meide, and K. Kristensson. 1990. Depletion of CD8+ T cells suppresses growth of Trypanosoma brucei brucei and interferon-gamma production in infected rats. Clin. Exp. Immunol. 81:195-199.
2. + T cells. Parasitol. Today. 8:237-239.
3. Olsson, T., M. Bakhiet, B. Hojeberg, A. Ljungdahl, C. Edlund, G. Andersson, H.-P. Ekre, W.-P. Fung-Leung, T. Mak, H. Wigzell, U. Fiszer, and K. Kristensson. 1993. CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule. Cell. 72:715-727.
4. + lymphocytes to interferon-γ secretion: purification, characterization and protective effects in vivo by treatment with a monoclonal antibody against the factor. Scand. J. Immunol. 37:165-178.
5. Bakhiet, M., T. Olsson, J. Mhlanga, P. Buscher, N. Lycke, P.H. Van der Meide, and K. Kristensson. 1996. Human and rodent interferon-γ as a growth factor for Trypanosoma brucei. Eur. J. Immunol. 26:1359-1364.
6. Alarcon, C.M., H.J. Son, T. Hall, and J.E. Donelson. 1994. A monocistronic transcript for a trypanosome variant surface glycoprotein. Mol. Cell. Biol. 14:5579-5591.
7. Altschul, S.F., W. Gish, W. Miller, E.W. Myers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
8. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387-395.
9. Harlow, E., and D. Lane. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 1-726.
10. Hug, M., V.B. Carruthers, C. Hartmann, D.S. Sherman, G.A.M. Cross, and C. Clayton. 1993. A possible role for the 3′-untranslated region in developmental regulation in Trypanosoma brucei. Mol. Biochem. Parasitol. 61:87-96.
11. Cormack, B.P., R.H. Valdivia, and S. Falkow. 1996. FACS-optimized mutants of the green fluorescent protein (GFP). Gene. 173:33-38.
12. Cunningham, I. 1977. New culture medium for maintenance of tsetse tissues and growth of trypanosomatids. J. Protozool. 24:325-329.
13. Rottenberg, M.E., M. Bakhiet, T. Olsson, K. Kristensson, T. Mak, H. Wigzell, and A. Orn. 1993. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect. Immun. 61:5129-5133.
14. Okamura, H., H. Tsutsul, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature (Lond.). 378:88-91.
15. + T cells: a trypanosome-released factor triggers interferon-γ production that stimulates parasite growth. Eur. J. Immunol. 21:2447-2454.
16. Schatz, G., and B. Dobberstein. 1996. Common principles of protein translocation across membranes. Science (Wash. DC). 271:1519-1526.
17. Webster, P., and D.G. Russell. 1993. The flagellar pocket of trypanosomatids. Parasitol. Today. 9:201-206.
18. Muesch, A., E. Hartmann, K. Rohde, A. Rubartelli, R. Sitia, and T.A. Rapoport. 1990. A novel pathway for secretory proteins? TIBS. 15:86-88.
19. Tagaya, Y., Y. Maeda, A. Mitsui. N. Kondo, H. Matsui, J. Hamuro, N. Brown, K. Arai, T. Yokota, H. Wakasugi, and J. Yodoi. 1989. ATL-derived factor (ADF), an IL-2 receptor/ Tac inducer homologous to thioredoxin: possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO (Eur. Mol. Biol. Organ.) J. 8:757-764.
20. Cleves, A., D. Cooper, S. Barondes, and R. Kelly. 1996. A new pathway for protein export in Saccharomyces cerevisiae. J. Cell Biol. 133:1017-1026.
21. Rubartelli, A., A. Bajetto, G. Allavena, E. Wollman, and R. Sitia. 1992. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J. Biol. Chem. 267:24161-24164.
22. Gutteridge, W.E. 1987. New antiprotozoal agents. Int. J. Parasitol. 17:121-130.
23. McKerrow, J.H. 1993. The proteases and pathogenicity of parasitic protozoa. Annu. Rev. Microbiol. 47:821-853.
24. Lonsdale-Eccles, J.D., W.N. Mpimbaza, R.M. Nkhungulu, J. Olobo, L. Smith, O.M. Tosomba, and D.J. Grab. 1995. Trypanosomatid cysteine protease activity may be enhanced by a kininogen-like moiety from host serum. Biochem. J. 305: 549-556.
25. Kapur, V., M.W. Majesky, L.-L. Li, R.A. Black, and J.M. Musser. 1993. Cleavage of interleukin 1β (IL-1β) precursor to produce active IL-1β by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc. Natl. Acad. Sci. USA. 90:7676-7680.
26. LaMarre, J., G.K. Wollenberg, S.L. Gonias, and M.A. Hayes. 1991. Cytokine binding and clearance properties of proteinase-activated α2-macroglobulins. Lab. Invest. 65:3-14.
27. Sileghem, M., J.N. Flynn, A. Darji, P. De Baetselier, and J. Naessens. 1994. African Trypanosomiasis. In Parasite Infections and the Immune System. F. Kierszenbaum, editor. Academic Press, Inc., San Diego. 1-51.
28. Donelson, J.E. 1995. Mechanisms of antigenic variation in Borrelia hermsii and African trypanosomes. J. Biol. Chem. 270: 7783-7786.
29. Gooding, L.R. 1992. Virus proteins that counteract host immune defenses. Cell. 71:5-7.
30. Wilson, M.E., K.K. Hardin, and J.E. Donelson. 1989. Expression of the major surface glycoprotein of Leishmania donovani chagasi in virulent and attenuated promastigotes. J. Immunol. 143:678-684.
31. de Jesus, A.R., R. Cooper, M. Espinosa, J.E. Gomes, E.S. Garcia, S. Paul, and G.A. Cross. 1993. Gene deletion suggests a role for Trypanosoma cruzi surface glycoprotein GP72 in the insect and mammalian stages of the life cycle. J. Cell Sci. 106: 1023-1033.