A Case Report of a Double-Blind, Randomized Trial of Inhaled Steroids in a Patient with Lung Transplant Bronchiolitis Obliterans

Respiration

Volumn 64, Issue 5, 1997, Pages 375-380

  Speich, Rudolf ^a   Boehler, Annette ^a   Russi, Erich W ^a   Weder, Walter ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Bronchiolitis obliterans; Immunosuppression; Lung transplantation; n of 1 trial

Indexed keywords

FLUTICASONE PROPIONATE; STEROID;

ADULT; ARTICLE; BRONCHIOLITIS; CASE REPORT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DYSPNEA; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; LUNG TRANSPLANTATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEROID THERAPY;

ADMINISTRATION, INHALATION; ADULT; ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; BRONCHIOLITIS OBLITERANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LUNG TRANSPLANTATION; RESPIRATORY FUNCTION TESTS;

EID: 0030748642     PISSN: 00257931     EISSN: 14230356     Source Type: Journal    
DOI: 10.1159/000196708     Document Type: Article

References (24)

1. Maurer JR: Lung transplantation bronchiolitis obliterans: in Epler GR (cd): Diseases of the Bronchioles, New York, Raven, 1994, pp 275-289.
2. Paradis I, Yousem S, Grifith B: Airway obstruction and bronchiolitis obliterans after lung transplantation, Clin Chest Med 1993; 14:751-763.
3. Levine SM, Bryan CL: Bronchiolitis obliterans in lung transplant recipients, The 'thorn in the side' of lung transplantation, Chest 1995:107: 894-897.
4. Scott JP, Higenbottam TW, Sharpies L, et al: Risk factors for obliterative bronchiolitis in heart-lung transplant recipients, Transplantation 1991:51:813-817.
5. Theodore J, Starnes VA, Lewiston NJ: Obliter-ative bronchiolitis, Clin Chest Med 1990;11: 309-321.
6. International Society for Heart and Lung Transplantation: A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts, J Heart Lung Transplant 1993; 12: 713-716.
7. Allen MD, Burke CM, McGregor CG, Baldwin JC, Jamieson SW, Theodore J: Steroid-respon-sive bronchiolitis after human heart-lung transplantation, J thorac Cardiovasc Surg 1986:92: 449-451.
8. Glanville AR, Baldwin JC, Burke CM, Theodore J, Robin HD: Obliterative bronchiolitis after heart-lung transplantation: Apparent arrest by augmented immunosuppression, Ann Intern Med 1987;107:300-304.
9. Novick RJ, Andreassian B, Schafers HJ, et al: Pulmonary retransplantation for obliterative bronchiolitis, Intermediate-term results of a North American-European series, J Thorac Cardiovasc Surg 1994:107:755-763.
10. Yousem SA, Berry GJ, Brunt EM, et al: A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Lung rejection study group, J Heart Transplant 1990:9:593-601.
11. Guvatt G, Sackctt D, Taylor W, Chong J, Roberts R, Pugsley S: Determining optimal therapy - Randomized trials in individual patients, N Engl J Med 1986;314:889-892.
12. Guyatt GH, Keller JL, Jaeschke R, Rosen-bloom D, Adachi JD, Newhouse MT: The n-of-1 randomized controlled trial: Clinical usefulness, Our three-year experience, Ann Intern Med 1990:112:293-299.
13. Patel A, Jaeschke R, Guyatt GH, Keller JL, Newhouse MT: Clinical usefulness of n-of-1 randomized controlled trials in patients with nonrcversible chronic airflow limitation, Am Rev Respir Dis 1991; 144:962-964.
14. Mahler DA, Weinberg DH, Wells CK, Fcin-stein AR: The measurement of dyspnea, Contents, interobservcr agreement, and physiologic correlates of two new clinical indexes, Chest 1984:85:751-758.
15. Brooks SM (chairman), Task Group on Screening for Respiratory Disease in Occupational Settings: Surveillance for respiratory hazards in the occupational setting, Official Statement of the American Thoracic Society, Am Rev Respir Dis 1982;126:952-956.
16. Guyatt GH: A measure of quality of life for clinical trials in chronic lung disease, Thorax 1987;42:773-778.
17. Otulana BA, Higenbottam T, Ferrari L, Scott J, Igboaka G, Walhvork J: The use of home spirometry in detecting acute lung rejection and infection following heart-lung transplantation, Chest 1990;97:353-357.
18. Takao M, Higenbottam TW, Audley T, Otulana BA, Wallwork J: Effects of inhaled nebulized steroids (budesonide) on acute and chronic lung function in heart-lung transplant patients, Transplant Proc 1995;27:1284-1285.
19. Mahler DA, Wells CK: Evaluation of clinical methods for rating dyspnea, Chest 1988:93: 580-586.
20. Keenan RJ, Duncan AJ, Yousem SA, et al: Improved immunosuppression with aerosolized cyclosporine in experimental pulmonary transplantation, Transplantation 1992:53:20-25.
21. Takao M, Katavama Y, Onoda K, et al: Significance of bronchial mucosal blood flow for the monitoring of acute rejection in lung transplantation, J Heart Lung Transplant 1991:10:956-967.
22. Novick RJ, Ahmad D, Menkis AH, et al: The importance of acquired diffuse bronchomala-cia in heart-lung transplant recipients with obliterative bronchiolitis, J Thorac Cardiovasc Surg 1991;101:643-648.
23. Iacono A, Keenan RJ, Zeevi A, et al: Aerosolized cyclosporine improves acute allograft rejection refractory to conventional immunosuppression, Am J Respir Crit Care Med 1995; 151A, 258.
24. Larson EB, Ellsworth AJ, Oas J: Randomized clinical trials in single patients during a 2-year period, JAMA 1993:270:2708-2712.