Facile and efficient synthesis of 7,10-dihydroxy-6h-pyrazolo[4,5,1- de]acridin-6-one via hypervalent iodine oxidation

Synthesis

Volumn , Issue 6, 1997, Pages 625-627

  Kato, Nobuyuki ^a   Sugaya, Toru ^a   Mimura, Takashi ^a   Ikuta, Masanori ^a,b   Kato, Sachiko ^a   Kuge, Yukihiro ^a   Tomioka, Shinji ^a,b   Kasai, Masaji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b Kyowa Yuka Co Ltd   (Japan)

Author keywords

Fused beterocyclic compound; Hypervalent iodine oxidation; Pyrazoloacridine derivative; Quinone intermediate of antitumor agent

Indexed keywords

ACRIDINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; OXIDATION; REACTION ANALYSIS; SYNTHESIS;

EID: 0030748628     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1997-1398     Document Type: Article

References (16)

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13. Quite recently, Kinugawa et al. reported the oxidation of the amino indole derivative to indoloquinone with BTIB in the synthesis of an intermediate to antitumor agent EO 9; Kinugawa, M.; Masuda, Y.; Arai, H.; Nishikawa, H.; Ogasa, T.; Tomioka, S.; Kasai, M. Synthesis 1996, 633.
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15. 2O (4:1), 0.24 mg/mL in MeCN. 0.25 mg mL in HOAc and 1.38 mg/mL in TFA at 50 C.
16. The adaptation of the oxidation reported here to the large-scale synthesis of KW-2170 and to other substrates is now being developed in our laboratory.