Behaviors and neurodegeneration induced by two blockers of K+ channels, the mast cell degranulating peptide and Dendrotoxin I

Brain Research

Volumn 762, Issue 1-2, 1997, Pages 223-227

  Mourre, C ^a   Lazdunski, M ^b   Jarrard, L E ^c  

^a IBHOP   (France)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c WASHINGTON AND LEE UNIVERSITY   (United States)

Author keywords

Brain damage; Cerebellum; Hippocampus; Seizure; Toxicity; Voltage dependent K+ channel

Indexed keywords

DENDROTOXIN; MAST CELL DEGRANULATING PEPTIDE; POTASSIUM CHANNEL;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; CEREBELLUM; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NEOCORTEX; NERVE CELL LESION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SEPTUM PELLUCIDUM; SUBICULUM; THALAMUS NUCLEUS;

ANIMALS; BEE VENOMS; BEHAVIOR, ANIMAL; CEREBELLUM; ELAPID VENOMS; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; ION CHANNEL GATING; MALE; NERVE DEGENERATION; NEUROTOXINS; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 0030748242     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00481-2     Document Type: Article

References (15)

1. + channel blocker- involves non-NMDA receptor activation. Neurochem. Int. 24(1):1994;81-90.
2. + channel blocker. Neurosci. Lett. 139:1992;24-40.
3. + channels, have interacting receptor sites. Biochem. Biophys. Res. Commun. 143(1):1987;383-389.
4. + channel toxins, MCD and dendrotoxin I. Brain Res. 495:1989;45-57.
5. Cherubini E., Ben-Ari Y., Gho M., Bidard J.N., Lazdunski M. A bee venom peptide induces long term potentiation of synaptic transmission in the hippocampus. Nature. 328:1987;70-73.
6. Gandolfo G., Gottesmann C., Bidard J.N., Lazdunski M. K channel openers prevent epilepsy induced by the bee venom peptide MCD. Eur. J. Pharmacol. 159:1989;329-330.
7. Harvey A.L., Anderson A.J. Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. Pharmacol. Ther. 31:1985;33-55.
8. + channel opener lemakalim. Brain Res. 554:1991;22-29.
9. Jarrard L.E. Use of ibotenic acid to selectively lesion brain structures. Methods Neurosci. 7:1991;58-69.
10. Mourre C., Bidard J.N., Lazdunski M. High affinity receptors for the bee venom MCD. Quantitative autoradiographic localization at different stages of brain development and relationship with MCD neurotoxicity. Brain Res. 446:1988;106-112.
11. Nadler J.V., Perry B.W., Cotman C.W. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature. 271:1978;676-677.
12. Schwob J.E., Fuller T., Price J.L., Olney J.W. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study. Neuroscience. 5:1980;991-1014.
13. Silveira R., Siciliano J., Abo V., Viera L., Dajas F. Intrastriatal dendrotoxin injection: behavioral and neurochemical effects. Toxicon. 26:1988;1009-1015.
14. Smith M.L., Auer R.N., Siesjö B.K. The density and distribution of ischemic brain injury in the rat following two to ten minutes of forebrain ischemia. Acta Neuropathol. 64:1984;319-332.
15. Stühmer W., Ruppersberg J.P., Schröter K.H., Sakmann B., Stocker M., Giese K.P., Perschke A., Baumann A., Pongs O. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J. 8(11):1989;3235-3244.