Transfer of endoplasmic reticulum and Golgi retention signals to human immunodeficiency virus type 1 gp 160 inhibits intracellular transport and proteolytic processing of viral glycoprotein but does not influence the cellular site of virus particle budding

Journal of General Virology

Volumn 78, Issue 7, 1997, Pages 1745-1753

  Pfeiffer, Tanya ^a   Zentgraf, Hanswalter ^a   Freyaldenhoven, Bettina ^a   Bosch, Valerie ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 160; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TRANSPORT; VIRUS CELL INTERACTION; VIRUS PARTICLE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030747371     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-7-1745     Document Type: Article

References (43)

1. Abacioglu, Y. H., Fouts, T. R., Laman, J. D., Claassen, E., Pincus, S. H., Moore, J. P., Roby, C. A., Kamin-Lewis, R. & Lewis, G. K. (1994). Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodies. AIDS Research and Human Retroviruses 10, 371-381.
2. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A. & Martin, M. A. (1986). Production of acquired immunodeficiency syndrome-associated retrovirus in human and non-human cells transfected with an infectious molecular clone. Journal of Virology 59, 284-291.
3. Bosch, V. & Pawlita, M. (1990). Mutational analysis of the human immunodeficiency virus type 1 env gene product proteolytic cleavage site. Journal of Virology 64, 2337-2344.
4. env, the precursor to the glycoproteins of Rous sarcoma virus: use of inhibitors of oligosaccharide trimming and glycoprotein transport. Virology 132, 95-109.
5. Bosshart, H., Humphrey, J., Deignan, E., Davidson, J., Drazba, J., Yuan, L., Oorschot, V., Peters, P. J. & Bonifacino, J. S. (1994). The cytoplasmic domain mediates localisation of furin to the trans-Golgi network en route to the endosomal/lysosomal system. Journal of Cell Biology 126, 1157-1172.
6. Chesebro, B. & Wehrly, K. (1988). Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity. Journal of Virology 62, 3779-3788.
7. Dorfman, T., Mammano, F., Haseltine, W. A. & Gottlinger, H. G. (1994). Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein. Journal of Virology 68, 1689-1696.
8. Fäcke, M., Janetzko, A., Shoeman, R. L. & Kräusslich, H.-G. (1993). A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulum. Journal of Virology 67, 4972-4980.
9. Franke, W. W., Lüder, M. R., Kartenbeck, J., Zerban, H. & Keenan, T. W. (1976). Involvement of vesicle coat material in casein secretion and surface regeneration. Journal of Cell Biology 69, 173-195.
10. Gebhardt, A., Bosch, J. V., Ziemiecki, A. & Friis, R. R. (1984). Rous sarcoma virus p19 and gp35 can be chemically cross-linked to high molecular weight complexes: an insight into virus assembly. Journal of Molecular Biology 174, 297-317.
11. Hallenberger, S., Bosch, V., Angliker, H., Shaw, E., Klenk, H.-D. & Garten, W. (1992). Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature 360, 358-361.
12. Hansen, M., Jelinek, L., Whiting, S. & Barklis, E. (1990). Transport and assembly of Gag proteins into Moloney murine leukemia virus. Journal of Virology 64, 5306-5316.
13. Hansen, M., Jelinek, L., Jones, R. S., Stegeman-Olsen, J. & Barklis, E. (1993). Assembly and composition of intracellular particles formed by Moloney murine leukemia virus. Journal of Virology 67, 5163-5174.
14. Hobman, T. C. (1993). Targeting of viral glycoproteins to the Golgi complex. Trends in Microbiology 1, 124-130.
15. Jackson, M. R., Nilsson, T. & Peterson, P. P. (1990). Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO Journal 9, 3153-3162.
16. Jackson, M. J., Nilsson, T. & Peterson, P. P. (1993). Retrieval of transmembrane proteins to the endoplasmic reticulum. Journal of Cell Biology 121, 317-333.
17. Kantanen, M. L., Leinikki, P. & Kuismanen, E. (1995). Endoproteolytic cleavage of HIV-1 gp160 envelope precursor occurs after exit from the trans-Golgi network (TGN). Archives of Virology 140, 1441-1449.
18. Kimpton, J. & Emerman, M. (1992). Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene. Journal of Virology 66, 2232-2239.
19. Kräusslich, H.-G., Ochsenbauer, C., Traeckner, A.-M., Mergener, K., Fäcke, M., Gelderblom, H. R. & Bosch, V. (1993). Analysis of protein expression and virus-like particle formation in mammalian cell lines stably expressing HIV-1 gag and env gene products with or without active HIV proteinase. Virology 192, 605-617.
20. Kunkel, T. A. (1985). Rapid and efficient site-specific mutagenesis without phenotypic selection. Proceedings of the National Academy of Sciences, USA 82, 488-492.
21. Lee, B. A. & Donaghue, D. J. (1992). Intracellular retention of membrane-anchored v-sis protein abrogates autocrine signal transduction. Journal of Cell Biology 118, 1057-1070.
22. Lodge, R., Göttlinger, H., Gabuzda, D., Cohen, E. A. & Lemay, G. (1994). The intracytoplasmic domain of gp41 mediates polarized budding of human immunodeficiency virus type 1 in MDCK cells. Journal of Virology 68, 4857-4861.
23. Lyles, D. S., McKenzie, M. & Parce, J. W. (1992). Subunit interactions of vesicular stomatitis virus envelope glycoprotein stabilized by binding to viral matrix protein. Journal of Virology 66, 349-358.
24. McCune, J. M., Rabin, L. B., Feinberg, M. B., Liebermann, M., Kosek, J. C., Reyes, G. R. & Weissman, I. L. (1988). Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus. Cell 53, 55-67.
25. Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A. & Axel, R. (1986). The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47, 333-348.
26. Molley, S. S., Thomas, L., Van Slyke, J. K., Stenberg, P. E. & Thomas, G. (1994). Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO Journal 13, 18-33.
27. Myers, G., Korber, B., Wain-Hobson, S., Smith, R. F. & Pavlakis, G. N. (editors) (1995). Human Retroviruses and AIDS: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences. Los Alamos: Los Alamos National Laboratory.
28. Nilsson, T. & Warren, G. (1994). Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus. Current Opinion in Cell Biology 6, 517-521.
29. Nilsson, T., Jackson, M. & Peterson, P. P. (1989). Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum. Cell 58, 707-718.
30. Owens, R. J. & Compans, R. W. (1989). Expression of the human immunodeficiency virus envelope glycoprotein is restricted to basolateral surfaces of polarized epithelial cells. Journal of Virology 63, 978-982.
31. Owens, R. J., Dubay, J. W., Hunter, E. & Compans, R. W. (1991). Human immunodeficiency virus envelope protein determines the site of virus release in polarized epithelial cells. Proceedings of the National Academy of Sciences, USA 88, 3987-3991.
32. Pear, W. S., Nolan, G. P., Scott, M. L. & Baltimore, D. (1993). Production of high-titer helper-free retroviruses by transient transfection. Proceedings of the National Academy of Sciences, USA 90, 8392-8396.
33. Pincus, S., Wehrly, K. & Chesebro, B. (1989). Treatment of HIV tissue culture infection with monoclonal antibody - ricin A conjugates. Journal of Immunology 142, 3070-3075.
34. Raja, N. U., Vincent, M. J. & Jabber, M. A. (1993). Analysis of endoproteolytic cleavage and intracellular transport of human immunodeficiency virus type 1 envelope glycoproteins using mutant CD4 molecules bearing the transmembrane endoplasmic reticulum retention signal. Journal of General Virology 74, 2085-2097.
35. Sanderson, C. M., McQueen, N. L. & Nayak, D. P. (1993). Sendai virus assembly: M protein binds to viral glycoproteins in transit through the secretory pathway. Journal of Virology 67, 651-663.
36. Schäfer, W., Stroh, A., Berghofer, S., Seiler, J., Vey, M., Kruse, M.-L., Kern, H. F., Klenk, H.-D. & Garten, W. (1995). Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localisation and endosomal trafficking of the proprotein convertase furin. EMBO Journal 14, 2424-2435.
37. Stein, B. S. & Engleman, E. G. (1990). Intracellular processing of the gp160 HIV-1 envelope precursor: endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex. Journal of Biological Chemistry 265, 2640-2649.
38. Swift, A. & Machamer, C. E. (1991). A Golgi retention signal in a membrane-spanning domain of corona virus E1 protein. Journal of Cell Biology 115, 19-30.
39. Traunecker, A., Oliveri, P. & Karyalainen, K. (1991). Myeloma-based expression system for production of large mammalian proteins. Trends in Biotechnology 9(4), 109-113.
40. Wilk, T., Pfeiffer, T. & Bosch, V. (1992). Retained in vitro infectivity and cytopathogenicity of HIV-1 despite truncation of the C-terminal tail of the env gene product. Virology 189, 167-177.
41. Wilk, T., Pfeiffer, T., Bukovsky, A., Moldenhauer, G. & Bosch, V. (1996). Glycoprotein incorporation and HIV-1 infectivity despite exchange of the gp160 membrane-spanning domain. Virology 218, 269-274.
42. Willey, R., Bonifacino, J. S., Potts, B. J., Martin, M. A. & Klausner, R. D. (1988). Biosynthesis, cleavage and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160. Proceedings of the National Academy of Sciences, USA 85, 9580-9584.
43. Yu, X., Yuan, X., McLane, M., Lee, T. H. & Essex, M. (1992). The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions. Journal of Virology 66, 4966-4971.