Age-related changes in the reactivity of post-synaptic adrenoceptors in the rat vas deferens: differences between the epididymal and prostatic portion

Journal of Autonomic Pharmacology

Volumn 17, Issue 3, 1997, Pages 147-154

  Markus, R P ^a   De Avellar, M C W ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR; CLONIDINE; PHENTOLAMINE; PHENYLEPHRINE; PRAZOSIN; RECEPTOR SUBTYPE; YOHIMBINE;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SENSITIVITY; EPIDIDYMIS; IN VITRO STUDY; MALE; NONHUMAN; PROSTATE; RAT; TECHNIQUE; VAS DEFERENS; VASOCONSTRICTION;

EID: 0030747284     PISSN: 01441795     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2680.1997.00449.x     Document Type: Article

References (38)

1. 1-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen. Br. J. Pharmacol., 109, 80-87.
2. ARUNLAKSHANA O. & SCHILD, M.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol., 14, 48-58.
3. 2 adrenoeeptors in the rat vas deferens. J. Pharmacol. Exp. Therap., 267, 38-44.
4. AVELLAR, M.C.W., KOBASHI, Y.L. & MARKUS, R.P. (1990). Age-related changes in the neuronal uptake of noradrenaline in the rat vas deferens. Naunyn Schmiedeberg's Arch. Pharmacol., 341, 295-300.
5. BADIA A. & SALES, J. (1989). Effects of St-587 on the alpha adrenoceptors in the bisected rat vas deferens. J. Pharm. Pharmacol., 41, 612-616.
6. BRITO A.R.M.S., MEDEIROS, I.A. & MARKUS, R.P. (1989). Do differences in innervation result in different post-synaptic response to exogenous agonists? Gen. Pharmacol., 20, 65-69.
7. BROWN, D.A., DOCHERTY, J.R., FRENCH, A.M., MACDONALD, A., MCGRATH, J.C. & SCOTT, N.C. (1983). Separation of adrenergic and non-adrenergic contractions to field stimulation in rat vas deferens. Br. J. Pharmacol., 79, 379-393.
8. CARNEIRO, R.C.G. & MARKUS, R.P. (1990). Presynaptic nicotinic receptors involved in release of noradrenaline and ATP from the prostatic portion of the rat vas deferens. J. Pharmacol. Exp. Therap., 255, 95-100.
9. CARVAJAL, A., VELASCO, A., MARTIN-ARIAS, L.H. & MAROTO, M. (1995). Age-related changes in contractile responses to noradrenaline in isolated blood vessels from cat and rabbit. J. Auton. Pharmacol., 15, 321-329.
10. DIXON, W.J. & MASSEY, F.J. JR. (1969). Introduction to Statistical Analysis, 3rd edn. McGraw-Hill, New York.
11. DOCHERTY, J.R. & O'MALLEY, K. (1983). An examination of age-related changes in pre- and postsynaptic α-adrenoceptors in the rat isolated vas deferens. Eur. J. Pharmacol., 95, 171-176.
12. DUCKLES, S.P., CARTER, B.J. & WILLIAMS, C.L. (1985). Vascular adrenergic neureffector function does not decline in aged rats. Circ. Res., 55, 109-116.
13. FURCHGOTT, R.F. (1972). The classification of adrenoceptors (adrenergic receptors). An evaluation from standpoint of receptor theory. In: Catecholamines, pp. 283-335. Ed. H. Blashco & E. Muschcholl. Springer-Verlag, Berlin.
14. 2+ in smooth muscle. Nature, 329, 333-335.
15. 1-adrenergic receptor recognition sites of the rat vas deferens as a cause of regional difference in the sensitivity to norepinephrine. Arch. Int. Pharmacodyn. Ther., 241, 24-31.
16. HAYASHI, S. & TODA, N. (1978). Age-related changes in the response of rabbit isolated aortae to vasoactive agents. Br. J. Pharmacol., 64, 229-237.
17. KASUYA, Y., & SUZUKI, N. (1979). Variation of postjunctional natures along the length of the rat vas deferens as a cause of regional difference in the sensitivity to norepinephrine. Archives Int. Pharmacodyn. Therap., 241, 24-31.
18. KENAKIN, T.P. (1979). Schild regressions as indicators of non-equilibrium steady-states and heterogeneous receptor populations. Trends Pharmacol. Sci., 6, 68-71.
19. 1A-adrenoceptor characterized in rat cerebral cortex and vas deferens. Br. J. Pharmacol., 111, 1003-1008.
20. LAI, R-T., WATANABE, Y. & YOSHIDA, H. (1983). The influence of aging on α-adrenoceptors in rat heart and vas deferens. Japan. J. Pharmacol., 33, 246-248.
21. MACDONALD, A. & MCGRATH, J.C. (1980). The distribution of adrenoceptors and other drug receptors between the two ends of the rat vas deferens as revealed by selective agonists and antagonists. Br. J. Pharmacol., 71, 445-458.
22. 1B-adrcnoceptor mediated components in the tension response of the rat vas deferens to electrical field stimulation. Br. J. Pharmacol., 105, 727-731.
23. MARKUS, R.P. & AVELLAR, M.C.W. (1992). Effect of ageing on the number of neuronal noradrenaline uptake sites in the rat vas deferens. Naunyn Schmiedeberg's Arch. Pharmacol., 346, 405-409.
24. MCGRATH, J.C. (1978) Adrenergic and non-adrenergic components in the contractile response of rat vas deferens to a single indirect stimulus. J. Physiol., 283, 23-39.
25. 3H] prazosin binding sites in canine brain membranes. Brain Res., 486, 56-66.
26. MILNOR, W.R. (1989). Limitations of Schild plot in a two-receptor system: & adrenoceptors of vascular smooth muscle. J. Pharmacol. Exp. Therap., 238, 237-241.
27. MOORE, P.K. & GRIFFITHS, R.J. (1982). Pre-synaptic and post-synaptic effects of xylazine and naphazoline on the bisected rat vas deferens. Arch. Int. Pharmacodyn., 260, 70-77.
28. 1-adrenoceptors involved in noradrenaline-induced contractions of rat thoracic aorta and dog carotid artery. Jpn. J. Pharmacol., 57, 535-544.
29. 1-adrenoceptor subtypes in the rat vas deferens: binding and functional studies. Br. J. Pharmacol., 107, 697-704.
30. 2 adrenergic receptors in rat aorta. J. Pharmacol. Exp. Therap., 217, 235-240.
31. 1-adrenoceptor activation in the bisected rat vas deferens. Br. J. Pharmacol., 102, 439-445.
32. SJÖSTRAND, N.O. (1981). Smooth muscles of vas deferens and other organs in the male reproductive tract. In: Smooth Muscle: An assessment of current knowledge, pp. 367-378. Eds E. Bülbring, A.F. Brading, A.W. Jones & T. Tomita. Edward Arnold, London.
33. SNEDECOR, G.W. & COCHRAN, W.G. (1980). Statistical Methods, 7th edn. Iowa State University Press, Ames, IA.
34. TAKAYANASHI, I., KOIKE, K., MAEDA, O. & ISHIZUKA, M. (1986). A difference in α-adrenoceptor mechanisms in vasa deferentia from young and old rats. Jap. J. Pharmacol., 41, 533-536.
35. 2 and receptor differentiation: a statistical analysis of competitive antagonism. Life Sci., 25, 637-654.
36. VANHOUTTE, P.M. (1988). Aging and vascular responsiveness. J. Cardiovasc. Pharmacol., 12(suppl. 8), S11-S18.
37. VAN ROSSUM, J.M. (1963). Cumulative dose-response curves in isolated organs and the evaluation of drug parameters. Arch. Int. Pharmacodyn., 143, 299-330.
38. VARDOLOV, S. & PENNEFATHER, J.N. (1976). Regional variation in the distribution of α-adrenoceptors in the vas deferens of the rat. Arch. Int. Pharmacodyn. Therap., 221, 212-222.