Synthesis of a new chiral (β-Aminoalkyl)phosphine ligand and its application to a catalytic asymmetric grignard Cross-Coupling reaction

Enantiomer

Volumn 2, Issue 3-4, 1997, Pages 293-296

  Hayashi, Minoru ^a   Takaoki, Kazuo ^a   Hashimoto, Yukihiko ^a   Saigo, Kazuhiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

( Aminoalkyl)phosphine; 2 Amino 1,2 diphenylethanol; Asymmetric Grignard Cross coupling; Chiral Aminophosphine Ligand

Indexed keywords

LIGAND; PALLADIUM; PHOSPHINE DERIVATIVE;

CHEMICAL MODIFICATION; CHEMICAL REACTION; CHIRALITY; CONFERENCE PAPER; DRUG SYNTHESIS; ENANTIOMER; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 0030747232     PISSN: 10242430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (16)

1. For recent reviews on catalytic asymmetric reactions: (a) Kagan, H. B. in Morrison, J. D. (editor), Asymmetric Synthesis, Academic Press, London, 1985, vol. 5, p. 1.
2. (b) Brunner, H. (1988). Synthesis, 645.
3. (c) Brunner, H. (1988). Top. Stereochem., 18, 129.
4. (d) Consiglio, G. and Waymouth, R. M. (1989). Chem. Rev., 89, 257.
5. (e) Noyori, R. and Kitamura, M. in Scheffold, R. (editor), Modem Synthetic Methods, Springer-Verlag, New York, 1989, vol. 5, p. 115.
6. (f) Ojima, I., Clos, N. and Bastos, C. (1989). Tetrahedron, 45, 6901.
7. (g) Frost, C. G., Howarth, J. and Williams, J. M. J. (1992). Tetrahedron Asymmetry, 3, 1089.
8. Uozumi, Y., Tanahashi, A., Lee, S. -Y. and Hayashi, T. (1993). J. Org. Chem., 58, 1945, and references cited therein.
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10. Dieter, R. K., Deo, N., Lagu, B. and Dieter, J. W. (1992). J. Org. Chem., 57, 1663.
11. 3) δ 1.30.
12. -3, R = 0.0474, reflections used = 1808.
13. (a) Hayashi, T., Konishi, M., Fukushima, M., Kanehira, K., Hioki, T. and Kumada, M. (1983). J. Org. Chem., 48, 2195.
14. (b) Hayashi, T., Hagihara, T., Katsuro, Y. and Kumada, M. (1983). Bull. Chem. Soc. Jpn., 56, 363.
15. (c) Hayashi, T., Konishi, M., Fukushima, M., Mise, T., Kagotani, M., Tajika, M. and Kumada, M. (1982). J. Am. Chem. Soc., 104, 180.
16. (d) Iida, A. and Yamashita, M. (1988). Bull. Chem. Soc. Jpn., 61, 2365.