Newer findings on a unified perspective of copper restriction and cardiomyopathy

Proceedings of the Society for Experimental Biology and Medicine

Volumn 215, Issue 4, 1997, Pages 299-313

  Medeiros, Denis M ^a   Wildman, Robert E C ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; CYTOCHROME C OXIDASE; FATTY ACID; LIPID; PROTEIN LYSINE 6 OXIDASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SUPEROXIDE DISMUTASE;

CARDIOMYOPATHY; COPPER DEFICIENCY; COPPER METABOLISM; DIET RESTRICTION; ENERGY METABOLISM; ENZYME ACTIVITY; FATTY ACID OXIDATION; HEART MITOCHONDRION; HEART MUSCLE METABOLISM; HEART VENTRICLE HYPERTROPHY; HUMAN; LIPID METABOLISM; NONHUMAN; SHORT SURVEY;

EID: 0030746712     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-215-44141     Document Type: Short Survey

References (156)

1. Medeiros DM, Davidson J, Jenkins J. A unified perspective on copper deficiency and cardiomyopathy. Proc Soc Exp Biol Med 203:262-273, 1993.
2. Allen KGD, Klevay LM. Cholesterolemia and cardiovascular abnormalities in rats caused by copper deficiency. Atherosclerosis 29:81-93, 1978.
3. Viestenz KE, Klevay LM. A randomized trial of copper therapy in rats with electrocardiographic abnormalities due to copper deficiency. Am J Clin Nutr 35:258-266, 1982.
4. Croswell SC, Lei KY. Effect of copper deficiency on the apolipoprotein E-rich high density lipoproteins in rats. J Nutr 115:473-482, 1985.
5. Lei KY. Alterations in plasma lipid, lipoprotein and apolipoprotein concentrations in copper-deficient rats. J Nutr 113:2178-2183, 1983.
6. Ovecka GD, Miller G, Medeiros DM. Fatty acids of liver, cardiac and adipose tissues from copper-deficient rats. J Nutr 118:480-486, 1988.
7. Borg TK, Klevay LM, Gay RE, Siegel R, Bergin ME. Alteration of the connective tissue network of striated muscle in copper-deficient rats. J Mol Cell Cardiol 17:1173-1183, 1985.
8. Bird DW, Savage JE, O'Dell BL. Effect of copper deficiency and inhibitors on the amine oxidase activity of chick tissues. Proc Soc Exp Biol Med 123:250-254, 1966.
9. Klevay LM, Moore RJ, Leslie M. Effect of copper deficiency on blood pressure and plasma and lung angiotensin-converting enzyme activity in rats. Nutr Res 8:489-497, 1988.
10. Kelly WA, Kesterson JW, Carlton WW. Myocardial lesions in the offspring of female rats fed a copper deficient diet. Exp Mol Pathol 20:40-57, 1974.
11. Gross AM, Prohaska JR. Copper deficient mice have higher cardiac norepinephrine turnover. J Nutr 120:88-96, 1990.
12. Feller DJ, O'Dell BL. Dopamine and norepinephrine in discrete areas of the copper-deficient rat brain. J Neurochem 34:1259-1262, 1980.
13. Leigh LC. Changes in the ultrastructure of cardiac muscle in steers deprived of copper. Res Vet Sei 18:282-287, 1975.
14. Medeiros DM, Lin KN, Liu CF, Thome BM. Pregestational dietary copper restriction and blood pressure in the Long-Evans rat. Nutr Rep Int 30:559-564, 1984.
15. Wu BN, Medeiros DM, Liu CF, Thorne BM. Long term effects of dietary copper and sodium upon blood pressure in the Long-Evans rat. Nutr Res 4:305-314, 1984.
16. Medeiros DM, Bagby D, Ovecka G, McCormick R. Myofibrillar, mitochondrial and valvular morphological alterations in cardiac hypertrophy among copper-deficient rats. J Nutr 121:815-824, 1991.
17. Medeiros DM, Liao Z, Hamlin R. Copper deficiency in a genetically hypertensive cardiomyopathic rat: Electrocardiogram, functional and ultrastructural aspects. J Nutr 121:1026-1034, 1991.
18. Cohen NL, Keen CL, Hurley LS, Lonnerdal B. Determinants of copper-deficiency anemia in rats. J Nutr 115:710-725, 1985.
19. Shields GS, Coulson WF, Kimball DA, Carnes WH, Cartwright GE, Wintrobe MM. Studies in copper deficiency. XXXII. Cardiovascular lesions in copper-deficient swine. Am J Pathol 41:603-621, 1962.
20. Klevay LM, Milne DB, Wallwork JC. Comparison of some indices of copper deficiency in growing rats. Nutr Rep Int 31:963-971, 1985.
21. Dallman PR, Goodman JR. Enlargement of mitochondrial compartment in iron and copper deficiency. Blood 35:496-505, 1970.
22. Goodman JR, Warshaw JB, Dallman PR. Cardiac hypertrophy in rats with iron and copper deficiency: Quantitative contribution of mitochondrial enlargement. Pediatr Res 4:244-256, 1970.
23. Lear PM, Heller LJ, Prohaska J. Cardiac hypertrophy in copper-deficient rats is not attenuated by angiotensin II receptor antagonist L-158, 809. Proc Soc Exp Biol Med 212:284-291, 1996.
24. Wildman REC, Hopkins R, Failla ML, Medeiros DM. Marginal copper-restricted diets produce altered cardiac ultrastructure in the rat. Proc Soc Exp Biol Med 210:43-49, 1995.
25. Hunsaker HA, Morita M, Allen KGD. Marginal copper deficiency in rats: aortal morphology of elastin and cholesterol values in first-generation adult males. Atherosclerosis 51:1-19, 1984.
26. Davidson JA, Medeiros DM, Hamlin RL, Jenkins JE. Submaximal, aerobic exercise training exacerbates the cardiomyopathy of postweanling Cu-depleted rats. Biol Trace Elem Res 38:251-272, 1993.
27. Van der Vusse GJ, de Groot MJM. Interrelationship between lactate and cardiac fatty acid metabolism. Mol Cell Biochem 116:11-17, 1992.
28. Taegtmeyer H. Carbohydrate interconversions and energy production. Circulation 72(Suppl 4):1-8, 1985.
29. Neely JR, Rovetto MJ, Oram JF. Myocardial utilization of carbohydrate and lipids. Prog Cardiovasc Dis 15:289-329, 1972.
30. Neely JR, Morgan HE. Relationship between carbohydrate and lipid metabolism and the energy balance in heart muscle. Annu Rev Physiol 36:413-459, 1974.
31. Bing RJ, Siegel A, Ungar J, Gilbert M. Metabolism of the human heart II. Studies on fat, ketone and amino acid metabolism. Am J Med 16:504-515, 1954.
32. Blain J, Schaeffer H, Siegel A, Bing RJ. Studies of myocardial metabolism. Am J Med 20:820-833, 1956.
33. El-Alaoui-Talibi Z, Landormy S, Loireau A, Moravec J. Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts. Am J Physiol 262(Heart Circ Physiol 31):H1068-H1074, 1992.
34. Liedtke AJ. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog Cardiovasc Dis 23:321-336, 1981.
35. Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schönekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta 1213:263-276, 1994.
36. Keul J, Doll E, Steim H, Homburger H, Kern H, Reindell H. Uber den Stoffwechel des Menschlichen Herzens. I. Die Substrat Versorgung des gesundes menschlichen Herzens in Ruhe, während und nach körperlichen Arbeit. Pflugers Arch 282:1-27, 1965.
37. Keul J, Doll E, Steim H, Fleer U, Reindell H. Uber den Stoffwechel des Menschlichen Herzens. III. Der oxydative Stoffwechsel des menschlichen Herzens unter verschiedenen Arbeitsbedingungen. Pflugers Arch 282:43-53, 1965.
38. Page E, McCallister LP, Power B. Stereological measurements of cardiac ultrastructure implicated in excitation-contraction coupling. Proc Natl Acad Sci U S A 68:1465-1466, 1971.
39. Page E, McCallister LP. Quantitative electron microscopic description of heart muscle cells: Application to normal, hypertrophied and thyroxin-stimulated hearts. Am J Cardiol 31:172-181, 1973.
40. Bassingthwaighte JB, Yipintsoi T, Harvey RB. Microvasculature of the dog left ventricular myocardium. Microvasc Res 7:229-249, 1974.
41. Neely JR, Whitmer JT, Rovetto MJ. Affect of coronary blood flow on glycolytic flux and intracellular pH in isolated rat hearts. Circ Res 37:733-741, 1975.
42. Geigly JR. Scientific tables. In: Diem K, Ed. Documenta Geigy (6th ed). Ardsley, NY: Geigly Pharmaceut, 1962.
43. Van Der Vusse GJ, Prinzen FW, Van Bilsen M, Engels W, Reneman RS. Accumulation of lipids and lipid-intermediates in the heart during ischemia. Basic Res Cardiol 82(Suppl 1):157-167, 1987.
44. Van Der Vusse GJ, Roemen THM, Prinzen FW, Coumans WA, Reneman RS. Uptake and tissue content of fatty acids in dog myocardium under normoxic and ischemic conditions. Circ Res 50:538-546, 1982.
45. Van Der Vusse GJ, Roemen THM, Reneman RS. Assessment of fatty acids in dog left ventricular myocardium. Biochim Biophys Acta 617:347-352, 1980.
46. Olson RE, Hoeschen RJ. Utilization of endogenous lipids by the isolated perfused rat heart. Biochem J 103:791-801, 1967.
47. Van Der Vusse GJ, Glantz JFC, Stram HCG, Reneman RS. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev 72:881-940, 1992.
48. Roy PE. Lipid droplets in the heart interstitium: Concentration and distribution. Recent Adv Stud Card Struct Metab 10:17-27, 1975.
49. Figard PHD, Hejlik DP, Kaduse TL, Stoll LL, Spector AA. Free fatty acid release from endothelial cells. J Lipid Res 27:771-780, 1985.
50. Ballard F, Danforth W, Nagele S, Bing RJ. Myocardial metabolism of fatty acids. J Clin Invest 39:717-723, 1960.
51. Dole VPA. A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J Clin Invest 35:150-154, 1956.
52. Drake AJ, Haines JR, Noble MIM. Preferential uptake of lactate by the normal myocardium in dogs. Cardiovasc Res 14:65-72, 1980.
53. Cryer A. The role of the endothelium in myocardial lipoprotein dynamics. Mol Cell Biochem 88:7-15, 1989.
54. 1 activities of rat heart lipoprotein lipase. Influence of apolipoprotein C-II and C-III. Biochim Biophys Acta 530:91-98, 1979.
55. Smith LC, Scow RO. Chylomicrons. Mechanisms of transfer of lipolytic products to cells. Prog Biochem Pharmacol 15:109-138, 1979.
56. Clarke SD, Armstrong MK. Cellular lipid binding proteins: Expression, function, and nutritional regulation. FASEB J 3:2480-2487, 1989.
57. Glatz JFC, Van der Vusse GJ. Intracellular transport of lipids. Mol Cell Biochem 88:37-44, 1989.
58. Crisman TS, Claffey KP, Saouaf R, Hanspal J, Brecher P. Measurement of rat heart fatty acid binding protein by ELISA. Tissue distribution, developmental changes and subcellular distribution. J Mol Cell Cardiol 19:423-431, 1987.
59. Glatz JFC, Baerwaldt CF, Veerkamp JH, Kempen HJM. Diurnal variation of cytosolic fatty acid-binding protein content and of palmitate oxidation in rat liver and heart. J Biol Chem 259:4295-4300, 1984.
60. Vork MM, Glatz JFC, Surtel DAM, Knubben HJM, Van der Vusse GJ. A sandwich enzyme linked immuno-sorbent assay for the determination of rat heart fatty acid acid-binding protein using a streptavidin-biotin system. Application to tissue and effluent samples from normoxic rat heart perfusion. Biochim Biophys Acta 1075:199-205, 1991.
61. Neely JR, Rovetto MJ, Morgan HE. Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu Rev Physiol 36:413-459, 1974.
62. Bremer J. Carnitine-metabolism and functions. Physiol Rev 63:1420-1480, 1983.
63. Fritz I, Yue KTN. Long-chain carnitine acyl transferase and the role of acylcarnitine derivatives in the catalytic increase of fatty acid oxidation induced by carnitine. J Lipid Res 4:279-288, 1963.
64. Bieber LL. Carnitine. Annu Rev Biochem 57:261-283, 1988.
65. Lazarow PB. Rat liver peroxisomes catalyze the β-oxidation of fatty acids. J Biol Chem 253:1522-1528, 1978.
66. Bilheimer DW, Buja LM, Parkey RW, Bonte FJ, Willerson JT. Fatty acid accumulation and abnormal lipid deposition in peripheral and border zones of experimental myocardial infarcts. J Nucl Med 19:276-283, 1978.
67. Burton KP, Buja LM, Sen A, Willerson JT, Chien KR. Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload. Am J Pathol 124:238-245, 1986.
68. Kelly DP, Strauss AW. Inherited cardiomyopathies. N Engl J Med 330:913-919, 1994.
69. Criste ME, Rodgers RL. Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat. J Mol Cell Cardiol 26:1371-1375, 1994.
70. Lochner A, Kotze JCN, Benade AJS. Mitochondrial oxidative phosphorylation in low-flow hypoxia: Role of free fatty acids. J Mol Cell Cardiol 10:857-875, 1978.
71. Opie LH. Effects of regional ischemia on metabolism of glucose and fatty acids: Relative rates of aerobic and anaerobic energy production during myocardial infarction and comparison with effects of anoxia. Circ Res 38(Suppl 1):52-68, 1976.
72. Comblath M, Randle PJ, Parmeggiani A, Morgan HE. Regulation of glycogenolysis in muscle: Effects of glucagon and anoxia on lactate production, glycogen content, and phosphorylase activity in the perfused rat heart. J Biol Chem 00:1592-1597, 1963.
73. Rovetto MJ, Lamberton, WF, Neely JR. Mechanisms of glycolytic inhibition in ischemic rat hearts. Circ Res 37:742-751, 1975.
74. Mochizuki S, Neely JR. Control of glyceraldehyde-3-phosphate dehydrogenase in cardiac muscle. J Mol Cell Cardiol 11:221-236, 1979.
75. Moore KH, Radloff JF, Hull FE. Incomplete fatty acid oxidation by ischemic heart: β-Hydroxy fatty acid production. Am J Physiol 239:H257-H265, 1980.
76. Hochachka PW, Neely JR, Driedezic WR. Integration of lipid utilization with Krebs cycle activity in muscle. Fed Proc 36:2009-2014, 1977.
77. Whitmer JT, Idell-Wenger JA, Rovetto MJ. Control of fatty acid metabolism in ischemic and hypoxic hearts. J Biol Chem 253:4305-4309, 1978.
78. Burton KP, Templeton GH, Hagler HK, Willerson JT, Buja LM. Effect of glucose availability on functional membrane integrity, ultrastructure, and contractile performance following hypoxia and reoxygenation in isolated feline cardiac muscle. J Mol Cardiol 12:109-133, 1980.
79. Grong K, Jodalen H, Strangeland L, Vik-mo H, Lekven J. Cellular lipid accumulation in different regions of myocardial infarcts in cat during beta adrenergic blockade with timolol. Cardiovasc Res 20:248-255, 1986.
80. Wittels B, Spann JF. Defective lipid metabolism in the failing heart. J Clin Invest 47:1787-1794, 1968.
81. Whitmer JT. Energy metabolism and mechanical function in perfused hearts of Syrian hamsters with hypertrophic cardiomyopathy. J Mol Cell Cardiol 18:307-317, 1986.
82. Revis NW, Cameron AJV. Metabolism of lipids in experimentally hypertrophic hearts of rabbits. Metab Clin Exp 28:801-813, 1979.
83. Murthy SR, Pande SV. Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria. J Biol Chem 259:9082-9089, 1984.
84. Bishop SP, Altschuld RA. Increased glycolytic activity metabolism in cardiac hypertrophy and congestive failure. Am J Physiol 218:153-159, 1970.
85. Vessell ES, Osterland K, Beam AG, Kunkel HG. Isozymes of LDH in human tissue. J Clin Invest 41:2012-2019, 1962.
86. Wildman REC, Medeiros DM, Jenkins J. Comparative aspects of cardiac ultrastructure, morphometry, and electrocardiography of hearts from rats fed restricted dietary copper and selenium. Biol Trace Elem Res 46:51-66, 1994.
87. Wildman REC, Medeiros DM, McCoy E. Cardiac changes with dietary copper, iron, or selenium restriction: Organelle and basal laminae aberations, decreased ventricular function, and altered gross morphometry. J Tr Elem Exp Med 8:11-27, 1995.
88. Karsner HTO, Saphir O, Todd TW. The state of the cardiac muscle in hypertrophy and atrophy. Am J Pathol 1:351-371, 1925.
89. Wearn JT. Morphological and functional alterations of the coronary circulation. Harvey Lect 35:243-270, 1940.
90. Rovetto MJ, Whitmer JT, Neely JR. Comparison of the effects of anoxia and whole heart ischemia on carbohydrate utilization in isolated working rat hearts. Circ Res 32:699-711, 1976.
91. Jalili T, Medeiros DM, Wildman REC. Aspects of cardiomyopathy are exacerbated by elevated dietary fat in copper-restricted rats. J Nutr 126:807-816, 1995.
92. Wildman REC, Medeiros DM, Hamlin RL, Stills H, Jones DA, Bonagura JD. Aspects of cardiomyopathy in copper-deficient pigs: Echocardiography, electrocardiography, and ultrastructural findings. Biol Trace Elem Res 55:55-70, 1996.
93. Conatzer WE, Haning JA, Klevay LM. The effect of copper deficiency on heart microsomal phosphatidylcholine biosynthesis and concentration. Int J Biochem 18:1083-1087, 1986.
94. Chao JCJ, Medeiros DM, Altschuld RA, Hohl CM. Cardiac nucleotide levels and mitochondrial respiration in copper-deficient rats. Comp Biochem Physiol 104:163-168, 1993.
95. Liao Z, Allred J, Keen CL, McCune SA, Rucker RB, Medeiros DM. Copper deficiency alters isomyosin types and levels of laminin, fibronectin and cytochrome c oxidase subunits from rat hearts. Comp Biochem Physiol 111B:61-67, 1995.
96. Liao Z, Medeiros DM, McCune SA, Prochaska LJ. Cardiac levels of fibronectin, laminin, isomyosins, and cytochrome c oxidase of weanling rats are more vulnerable to copper-deficiency than postweanling rats. J Nutr Biochem 6:385-391, 1995.
97. Katz AM. Contractile proteins of the heart. Physiol Rev 50:63-158, 1970.
98. Hamrell BB, Alpert NA. Cellular basis of mechanical properties of hypertrophied myocardium. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgon HE, Eds. The Heart and Cardiovascular System: Scientific Foundations. New York: Raven Press, Vol 2:pp1507-1524, 1986.
99. Hoogeveen RCAJM, Reaves SK, Reid PM, Reid BL, Lei KY. Copper deficiency shifts energy substrate utilization from carbohydrate to fat and reduces fat mass in rats. J Nutr 124:1660-1666, 1994.
100. Abraham PA, Evans JL. Cytochrome oxidase activity and cardiac hypertrophy during copper depletion and repletion. In: Hemphill DD, Ed. Trace Substances in Environmental Health. University of Missouri, Columbia, MO. Vol 5:pp335-347, 1972.
101. Gennis R, Ferguson-Miller S. Structure of cytochrome c oxidase, energy generator of aerobic life. Science 269:1063-1064, 1995.
102. Hood DA. Coordinate expression of cytochrome c oxidase subunit III and VIc mRNAs in rat tissues. Biochem J 269:503-506, 1990.
103. Capaldi RA. Structure and assembly of cytochrome c oxidase. Arch Biochem Biophys 280:252-262, 1990.
104. Medeiros DM, Shiry L, Lincoln AJ, Prochaska L. Cardiac non-myofibrillar proteins in copper-deficient rats: Amino acid sequencing and Western blotting of altered proteins. Biol Trace Elem Res 36:271-282, 1993.
105. Chao JC, Medeiros DM, Davidson J, Shiry L. Decreased levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide. J Nutr 124:789-803, 1994.
106. Medeiros DM, Shiry L, Samelman T. Cardiac nuclear encoded cytochrome C oxidase subunits are decreased with copper restriction but not iron restriction: gene expression, protein synthesis and heat shock protein aspects. Comp Biochem Physiol 117A;1:77-87, 1997.
107. Rusinko N, Prohaska JR. Adenine nucleotide and lactate levels in organs from copper-deficient mice and brindled mice. J Nutr 115:936-943, 1985.
108. Fields M, Ferretti RJ, Reiser S, Smith JC Jr. The severity of copper deficiency in rats is determined by the type of dietary carbohydrate. Proc Soc Exp Biol Med 175:530-537, 1984.
109. Kopp SJ, Klevay LM, Feliksik JM. Physiologic and metabolic characterization of a cardiomyopathy induced by chronic copper deficiency. Am J Physiol 245:H855-H866, 1983.
110. Gulick T, Cresci S, Caira T, Moore D, Kelly DP. The peroxisome proliferator activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci U S A 91:11012-11016, 1994.
111. Kelly DP, Gordon JF, Alpers R, Strauss AW. The tissue specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins. J Biol Chem 264:18921-18925, 1989.
112. Raishner BD, Gulick T, Zhang AW, Moore DD, Kelly DP. Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. J Biol Chem 267:20264-20269, 1992.
113. Williams N, Hullihen J, Pederson PL. Mitochondrial ATP synthase: Role of metal binding in structure and function. Prog Clin Biol Res 273:87-92, 1988.
114. Bronnikov GE, Vinogradova SO, Chernyak BV. Regulation of ATP hydrolysis in liver of mitochondria from ground squirrel. FEBS Lett 266:83-86, 1990.
115. Dorgan JL, Urbauer JL, Schuster SM. Metal dependence and thermodynamic characteristics of the beef heart mitochondrial adenosine triphosphatase. J Biol Chem 259:2816-2821, 1984.
116. Davidson JA, Medeiros DM, Hamlin RL. Cardiac ultrastructure and electrophysiological abnormalities in postweanling copper-restricted and copper-repleted rats in the absence of hypertrophy. J Nutr 122:1566-1575, 1992.
117. Keyhani E, Keyhani J. Cytochrome c oxidase biosynthesis and assembly in Candida utilis yeast cells: Function of copper in the assembly of active cytochrome c oxidase. Arch Biochem Biophys 167:596-602, 1975.
118. Hay R, Bohni P, Gasser S. How mitochondria import protein. Biochim Biophys Acta 779:65-97, 1984.
119. Hartl FV, Pfanner N, Nicholson DW, Neupert W. Mitochondrial protein import. Biochim Biophys Acta 988:1-45, 1989.
120. Matz JM, Blake MJ, Saari JT, Bode AM. Dietary copper deficiency reduces hear shock protein expression in cardiovascular tissues. Fed Am Exp Biol Med J 8:97-102, 1994.
121. Matz JM, Bode AM, Roth P, Saari JT. Evidence for altered mitochondrial ATPase in hearts of copper-deficient rats. (abstract) FASEB J 7:A300, 1993.
122. Wang YR, Wu JY, Reaves SK, Lei KY. Enhanced expression of hepatic genes in copper-deficient rats detected by the messenger RNA differential display method. J Nutr 126:1772-1781, 1996.
123. Virbasius CA, Virbasius JV, Scarpulla RC. NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes and Dev 7:2431-2445, 1993.
124. Chau CM, Evans MJ, Scarpulla RC. Nuclear respiratory factor 1 activation sites in genes encoding the gamma-subunit of ATP synthase, eukaryotic initiation factor 2 alpha, and tyrosine aminotransferase. Specific interaction of purified NRF-1 with multiple target genes. J Biol Chem 267:6999-7006, 1992.
125. Spelbrink JN, Van den Bogert C. The pre-mRNA of nuclear respiratory factor 1, a regulator of mitochondrial biogenesis, is alternatively spliced in human tissues and cell lines. Hum Mol Genet 4:1591-1596, 1995.
126. Virbasius JV, Scarpulla RC. Activation of the human mitochondrial transcription factor A gene by nuclear regulatory factors: A potential regulatory link between nuclear and mitochondrial gene expression in organelle biosynthesis. Proc Natl Acad Sci U S A 91:1309-1312, 1994.
127. DiMauro S, Zeviani M, Rizzuto R, Lombes A, Nakase H, Bonilla E, Miranda A, Schon E. Molecular defects in cytochrome oxidase in mitochondrial diseases. J Bioenerg Biomem 20:353-364, 1988.
128. Mirand AF, Ishii S, DiMauro S, Shay JW. Cytochrome c oxidase deficiency in Leigh's syndrome: Genetic evidence for a nuclear DNA-encoded mutation. Neurology 39:697-702, 1989.
129. Mita S, Schmidt B, Schon E, DiMauro S, Bonilla E. Detection of "deleted" mitochondrial genomes in cytochrome c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome. Proc Natl Acad Sci U S A 86:9509-9513, 1989.
130. Schwartzkopff B, Ziers S, Frenzel H, Block M. Neuen-Jacob E, Reiners K, Strauer BE. Ultrastructural abnormalities of mitochondria and deficiency of myocardial cytochrome c oxidase in a patient with ventricular tachycardia. Virchows Arch (A) 49:63-68, 1991.
131. Medeiros DM, Failla ML, Schoenemann HM, Ovecka GD. Morphometric analysis of myocardium from copper-deficient pigs. Nutr Res 11:1439-1450, 1991.
132. Mullen-Hocker J, Johannes A, Droste M, Kadenbach B, Hubner G. Fatal mitochondrial cardiomyopathy in Kearns-Sayre syndrome with deficiency of cytochrome c oxidase in the cardiac tissue and skeletal muscle. An enzyme-histochemical-ultraimmunocytochemical structural study in the long term frozen autopsy tissue. Virchows Arch (B) 52:353-367, 1986.
133. Zeviani M, Van Dyke DH, Servidei S, Bausermann SC, Bonilla E, Beaumont ET, Sharda J, Van der Laan K, DiMauro S. Myopathy and fatal cardiopathy due to cytochrome c oxidase deficiency. Arch Neurol 43:1198-1202, 1986.
134. Buchwald A, Till H, Unterberg C, Oberschmidt R, Figulla HR, Wiegand V. Alterations of the mitochondrial respiratory chain in human cardiomyopathy. Eur Heart J 11:509-516, 1990.
135. Saari JT. Chronic treatment with dimethyl sulfoxide protects against cardiovascular defects of copper deficiency. Proc Soc Exp Biol Med 190:121-124, 1989.
136. Kubisch HM, Wang J, Luche R, Carlson E, Bray TM. Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes. Proc Natl Acad Sci U S A 91:9956-9959, 1994.
137. Johnson WT, Saari JT. Dietary supplementation with t-butyl-hydroquinone reduces cardiac hypertrophy and anemia associated with copper deficiency in rats. Nutr Res 9:1355-1362, 1989.
138. Weber KT. Cardiac interstitium in health and disease: the fibrillar collagen network. J Am Coll Cardiol 13:1637-1652, 1989.
139. Eghbali M, Weber KT. Collagen and myocardium: Fibrillar structure, biosynthesis and degradation in relation to hypertrophy and its regression. Mol Cell Biochem 96:1-14, 1990.
140. Dawson R, Milne G, Williams RB. Changes in the collagen of rat heart in copper-deficiency-induced cardiac hypertrophy. Cardiovasc Res 16:359-365, 1982.
141. Bonnin CM, Sparrow MP, Taylor RR. Collagen synthesis and content in right ventricular hypertrophy in the dog. Am J Physiol 10:H703-H713, 1981.
142. Laurent GJ, Sparrow MP, Bates PC, Millward DJ. Collagen content and turnover in cardiac and skeletal muscles of the adult fowl and the changes during stretch-induced growth. Biochem J 176:419-427, 1978.
143. Eghbali M, Czaja MJ, Zeyel M, Weiner FR, Zern MA, Seifter S, Blumenfeld OO. Collagen mRNAs in isolated adult heart cells. J Mol Cardiol 20:267-276, 1988.
144. Chapman D, Weber KT, Eghbali M. Regulation of fibrillar collagen types I and III and basement membrane type IV collagen gene expression in pressure overloaded rat myocardium. Circulation Res 67:787-794, 1990.
145. Vracko R, Cunningham D, Frederickson RG, Thorning D. Basal lamina: The scaffold for orderly cell replacement. Lab Invest 58:77-87, 1988.
146. Vadlamudi RK, McCormick RJ, Medeiros DM, Vossoughi J, Failla ML. Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves. Am J Physiol 264(Heart Circ Physiol 33):H2154-H2161, 1993.
147. Lefevre M, Rucker RB. Aorta elastin turnover in normal and hypercholesterolemic Japanese quail. Biochim Biophys Acta 630:519-529, 1980.
148. Shapiro SD, Endicott SK, Province MA, Pierce JA, Campbell EJ. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J Clin Invest 87:1828-1824, 1991.
149. Fields M, Ferretti RJ. Effect of dietary carbohydrates and copper status on blood pressure of rats. Life Sci 20:763-709, 1984.
150. Fields M, Reiser S, Ferretti RJ, Smith JC. The severity of copper deficiency in rats is determined by the type of dietary carbohydrates. Proc Soc Exp Biol Med 175:530-537, 1984.
151. Reiser S, Ferretti RJ, Fields S, Smith JC. Dietary fructose exacerbates the cardiac abnormalities of copper deficiency in rats. Atherosclerosis 74:203-214, 1988.
152. Fields M, Holbrook J, Scholfield D, Smith JC, Reiser S. Effect of fructose or starch on copper-67 absorption and excretion by the rat. J Nutr 116:625-632, 1986.
153. Holbrook J, Fields M, Smith JC, Reiser S, Los Alames Medical Research Group. Tissue distribution and excretion of copper intraperitoneally administered to rat fed fructose or starch. J Nutr 116:831-838, 1986.
154. Lei KY. Oxidation, excretion and tissue distribution of (26-14C) cholesterol in copper-deficient rats. J Nutr 108:232-237, 1978.
155. Lei KY. Cholesterol metabolism in copper-deficient rats. Nutr Rep Int 15:597-605, 1977.
156. Klevay LM, Medeiros DM. Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations about copper. J Nutr 126:2419S-2426S, 1996.