Phase I study of paclitaxel and oral etoposide in previously uutreated non-small-cell and extensive small-cell lung cancer

Annals of Oncology

Volumn 8, Issue 5, 1997, Pages 485-489

  Boyer, M J ^a   Zalcberg, J ^b   Olver, I N ^c   Millward, M J ^d   Richardson, G ^e   McKeage, M J ^f,g  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b AUSTIN HEALTH   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

^e MONASH MEDICAL CENTRE   (Australia)

^f PRINCE OF WALES HOSPITAL   (Australia)

^g UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Etoposide; Lung cancer; Paclitaxel; Phase I study

Indexed keywords

ETOPOSIDE; PACLITAXEL;

ADULT; AGED; ARTICLE; BLOOD CELL COUNT; BLOOD TOXICITY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DRUG SAFETY; FEMALE; HUMAN; HYPERSENSITIVITY; LEUKOPENIA; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MALE; NEUROTOXICITY; NEUTROPENIA; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; THORAX RADIOGRAPHY;

EID: 0030746678     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008291606695     Document Type: Article

References (21)

1. Non-Small-Cell Lung Cancer Collaborative Group. Chemotherapy in non-small-cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 1995; 311: 899-909.
2. Johnson DH, Chang AY, Ettinger DS. Taxol (paclitaxel) in the treatment of lung cancer: The Eastern Cooperative Oncology Group experience. Ann Oncol 1994; 5 (Suppl 6): S45-S50.
3. Ettinger DS. Overview of paclitaxel (Taxol) in advanced lung cancer. Semin Oncol 1993; 20: 46-9.
4. Millward MJ, Bishop JF, Friedlander M et al. Phase II trial of a three-hour infusion of paclitaxel in previously untreated patients with advanced non-small-cell lung cancer. J Clin Oncol 1996: 14: 142-8.
5. Murphy WK, Fossella FV, Winn RJ. Phase II study of Taxol in patients with untreated advanced non-small-cell lung cancer. J Natl Cancer Inst 1993; 85: 384-8.
6. Chang AY, Kim K, Glick J. Phase II study of Taxol, Merbarone. and Piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group results. J Natl Cancer Inst 1993; 85: 388-94.
7. Langer CJ, Leighton JC, Comis RL et al. Paclitaxel and carboplatin in combination in the treatment of advanced non-small-cell lung cancer: A phase II toxicity, response, and survival analysis. J Clin Oncol 1995; 13: 1860-70.
8. Belli L, LeChevalier T, Gottfried M et al. Phase III study of paclitaxel plus cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer: Preliminary results. Semin Oncol 1995; 22: 29-33.
9. Klaassen U, Harstrick A, Schleucher N et al. Activity- and schedule-dependent interactions of paclitaxel, etoposide and hydroperoxy-ifosfamide in cisplatin-sensitive and -refractory human ovarian carcinoma cell lines. Br J Cancer 1996; 74: 224-8
10. Perez EA, Hack F, Fletcher T et al. Sequence dependent cytotoxicity of taxol and etoposide in lung and breast human cancer cell lines. Proc Am Soc Clin Oncol 1995; 14: 491 (Abstr).
11. Hahn SM, Liebmann JE, Cook J et al. Taxol in combination with doxorubicin or etoposide. Possible antagonism in vitro. Cancer 1993; 72: 2705-11.
12. Rose WC. Taxol-based combination chemotherapy and other in vivo preclinical antitumor studies. Monogr Natl Cancer Inst 1993; 47-53.
13. Miller AB, Hoogstraten B. Staquet M, Winkler A. Reporting result of cancer treatment. Cancer 1981; 47: 207-14.
14. Oken MM, Creech RH, Tormey DC. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 12: 2471-508.
15. Perez EA, Coc T, Turrell C et al. Phase I study of paclitaxel with oral etoposide in advanced solid tumors. Cancer J Sci Am 1996; 2: 286-90.
16. Green MR, MacManus DA, Lilenbaum RC. A phase I trial of paclitaxel and eloposide for metastatic or recurrent malignancies. Semin Oncol 1995; 22 (Suppl 6): 128-31.
17. Hainsworth JD, Stroup SL, Greco FA. Paclitaxel, carboplatin. and extended schedule etoposide in the treatment of small-cell lung carcinoma. Cancer 1996; 77: 2458-63.
18. Bunn PA Jr, Kelly KL. A phase I study of cisplatin, etoposide. and paclitaxel in small-cell lung cancer: A University of Colorado Cancer Center study. Semin Oncol 1995; 22: 54-8.
19. Strauss GM, Lynch TJ, Elias AD et al. A phase I study of ifosfamide/carboplatin/etoposide/paclitaxel in advanced lung cancer. Semin Oncol 1995; 22: 70-4.
20. Chang AY, Boros L, Garrow GC et al. Ifosfamide, carboplatin. eloposide, and paclitaxel chemotherapy: A dose-escalation study. Semin Oncol 1996; 23: 74-7.
21. Greco FA, Stroup SL, Gray JR, Hainsworth JD. Paclitaxel in combination chemotherapy with radiotherapy in patients with unresectable stage III non-small-cell lung cancer. J Clin Oncol 1996; 14: 1642-8.