CD40 and its ligand in autoimmunity

Annals of the New York Academy of Sciences

Volumn 815, Issue , 1997, Pages 384-390

  Noelle, Randolph J ^a   Mackey, Matthew ^a   Foy, Teresa ^a   Buhlmann, Janet ^a   Burns, Christopher ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; GLYCOPROTEIN GP 39;

ANTIGEN PRESENTATION; AUTOIMMUNITY; B LYMPHOCYTE; CELL INTERACTION; CONFERENCE PAPER; CONTROLLED STUDY; ETIOLOGY; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; T LYMPHOCYTE ACTIVATION;

EID: 0030746363     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb52089.x     Document Type: Conference Paper

References (32)

1. GORDON, J., M. J. MILLSUM, G. R. GUY & J. A. LEDBETTER. 1987. Synergistic interaction between interleukin 4 and anti-Bp50 (CDw40) revealed in a novel B cell restimulation assay. Eur. J. Immunol. 17: 1535-1538.
2. CLARK, E. A. & J. A. LEDBETTER. 1986. Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc. Natl. Acad. Sci. U.S.A. 83: 4494.
3. STAMENKOVIC, I., E. A. CLARK & B. SEED. 1989. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8: 1403-1410.
4. HOLLENBAUGH, D., L. GROSMAIRE, C. D. KULLAS, N. J. CHALUPNY, R. J. NOELLE, I. STAMENKOVIC, J. A. LEDBETTER & A. ARUFFO. 1992. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 11: 4313-4321.
5. ARMITAGE, R. J., W. C. FANSLOW, L. STROCKBINE, T. A. SATO, K. N. CLIFFORD, B. M. MACDUFF, D. M. ANDERSON, S. D. GIMPEL, T. DA VIS-SMITH, C. R. MALISZEWSKI, E. A. CLARK, C. A. SMITH, K. H. GRABSTEIN, D. COSMAN & M. K. SPRIGGS. 1992. Molecular and biological characterization of a murine ligand for CD40. Nature 357: 80-82.
6. VALLE, A., C. E. ZUBER, T. DEFRANCE, O. DJOSSOU, R. M. DE & J. BANCHEREAU. 1989. Activation of human B lymphocytes through CD40 and interleukin 4. Eur. J. Immunol. 19: 1463-1467.
7. GORDON, J., M. J. MILLSUM, R. L. FLORES & S. GILLIS. 1989. Regulation of resting and cycling human B lymphocytes via the surface accessory molecules interleukin-4, CD23, and CD40. Immunology 68: 526-531.
8. JABARA, H. H., S. M. FU, R. S. GEHA & D. VERCELLI. 1990. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172: 1861-1864.
9. BANCHEREAU, J. & F. ROUSSET. 1991. Growing human B lymphocytes in the CD40 system. Nature 353: 678-679.
10. ARMITAGE, R. J., T. A. SATO, B. M. MACDUFF, K. N. CLIFFORD, A. R. ALPERT, C. A. SMITH & W. C. FANSLOW. 1992. Identification of a source of biologically active CD40 ligand. Eur. J. Immunol. 22: 2071-2076.
11. VAN DEN EERTWEGH, A. J. M., R. J. NOELLE, M. ROY, D. M. SHEPHERD, A. ARUFFO, J. A. LEDBETTER, W. J. A. BOERSMA & E. CLAASSEN. 1993. In vivo CD40-gp39 interactions are essential for thymus-dependent immunity: I. CD40-gp39 interactions are essential for thymus-dependent humoral immunity and identify sites of cognate interactions in vivo. J. Exp. Med. 178: 1555-1565.
12. NOELLE, R. J., J. A. LEDBETTER & A. ARUFFO. 1992. CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B cell activation. Immunol. Today 13: 431-434.
13. FOY, T., A. ARUFFO, J. BAJORATH, J. E. BUHLMANN & R. J. NOELLE. 1996. Immune regulation by CD40 and its ligand gp39. Annu. Rev. Immunol. 14: 591-617.
14. XU, J., T. M. FOY, J. D. LAMAN, J. J. DUNN, T. J. WALDSCHMIDT, J. ELSEMORE, R. J. NOELLE & R. A. FLAVELL. 1994. Mice deficient for the CD40 ligand. Immunity 1: 423-431.
15. RENSHAW, B. R., W. FANSLOW, R. J. ARMITAGE, K. A. CAMPBELL, D. LIGGITT, B. WRIGHT, B. L. DAVISON & C. R. MALISZEWSKI. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180: 1889-1900.
16. KAWABE, T., T. NAKA, K. YOSHIDA, T. TANAKA, H. FUJIWARA, S. SUEMATSU, N. YOSHIDA, T. KISHIMOTO & H. KIKUTANI. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1: 167-178.
17. FOY, T. M., A. ARUFFO, J. A. LEDBETTER & R. J. NOELLE. 1993. In vivo CD40-gp39 interactions are essential for thymus-dependent immunity: II. Prolonged in vivo suppression of primary and secondary humoral immune responses by an antibody targeted to the CD40 ligand, gp39. J. Exp. Med. 178: 1567-1575.
18. FOY, T. M., J. D. LAMAN, J. A. LEDBETTER, A. ARUFFO, E. CLAASSEN & R. J. NOELLE. 1994. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180: 157-164.
19. GRAY, D., P. DULLFORCE & S. JAINANDUNSING. 1994. Memory B cell development, but not germinal center formation, is impaired by in vivo blockade of CD40-CD40-ligand interaction. J. Exp. Med. In press.
20. BUHLMANN, J. E., T. M. FOY, A. ARUFFO, K. M. CRASSI, J. A. LEDBETTER, W. R. GREEN, J. XU, L. D. SHULTZ, D. ROOPESIAN, R. A. FLAVELL, L. FAST, R. J. NOELLE & F. H. DURIE. 1995. In the absence of a CD40 signal, B cells are tolerogenic. Immunity 2: 645-653.
21. PARKER, D. C., D. L. GREINER, N. E. PHILLIPS, M. C. APPEL, A. W. STEHLE, F. H. DURIE, R. J. NOELLE, J. P. MORDES & A. A. ROSSINI. 1995. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc. Natl. Acad. Sci. U.S.A. 92: 9560-9564.
22. DURIE, F. H., A. ARUFFO, J. A. LEDBETTER, K. M. CRASSI, W. R. GREEN & R. J. NOELLE. 1994. Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-versus-host disease. J. Clin. Invest. 94: 1333-1338.
23. DURIE, F. H., R. A. FAVA, T. M. FOY, A. ARUFFO, J. A. LEDBETTER & R. J. NOELLE. 1993. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 261: 1328-1330.
24. MOHAN, C., Y. SHI, J. D. LAMAN & S. K. DATTA. 1995. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J. Immunol. 154: 1470-1480.
25. GERRITSE, K., R. J. NOELLE, A. ARUFFO, J. A. LEDBETTER, J. D. LAMAN, W. J. A. BOERSMA & E. CLAASSEN. 1995. Functional and histological evidence for the involvement of gp39 (CD40 ligand) in multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A. In press.
26. GREWAL, I. S., J. XU & R. A. FLAVELL. 1995. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378: 617-620.
27. STUBER, E., W. STROBER & M. NEURATH. 1996. Blocking of CD40-CD40L interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183: 693-698.
28. HOLLENBAUGH, D., N. MlSCHEL-PETTY, C. P. EDWARDS, J. C. SLMON, R. W. DENFIELD, P. A. KIENER & A. ARUFFO. 1995. Expression of functional CD40 by vascular endothelial cells. J. Exp. Med. 182: 33-40.
29. KARMANN, K., C. W. HUGHES, J. SCHECHNER, W. C. FANSLOW & J. S. POBER. 1995. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc. Natl. Acad. Sci. U.S.A. 92: 4342-4346.
30. KIENER, P. A., D. P. MORAN, B. M. RANKIN, A. F. WAHL, A. ARUFFO & D. HOLLENBAUGH. 1995. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155: 4917-4925.
31. TIAN, L., R. J. NOELLE & D. A. LAWRENCE. 1995. Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1. Eur. J. Immunol. 25: 306-309.
32. STOUT, R. D., J. SUTTLES, J. XU, I. S. GREWAL & R. A. FLAVELL. 1996. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J. Immunol. 156: 8-11.