Cytoplasmic localization of endothelial constitutive nitric oxide synthase in endometrial carcinomas

Tumor Biology

Volumn 18, Issue 5, 1997, Pages 290-300

  Bentz, B G ^a   Barnes, M N ^a   Haines, G K ^a   Lurain, J R ^a   Hanson, D G ^a   Radosevich, J A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Endometrial cancer; Endothelial constitutive nitric oxide synthase; Immunohistochemistry; Nitric oxide

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER RECURRENCE; CANCER REGRESSION; CANCER STAGING; CANCER SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENDOMETRIUM CARCINOMA; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL;

EID: 0030746205     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1159/000218042     Document Type: Article

References (36)

1. Parker SL, Tong T, Bolden S, Wingo PA: Cancer statistics, 1996, CA Cancer J Clin 1996;65:25-27.
2. Lurain JR, Rice BL, Radcmaker AW, Schink JL, Miller DS: Prognostic factors associated with recurrence in clinical stage I adenocarcinoma of the endometrium, Obstet Gynecol 1991;78:63-68.
3. Morrow CP, Bundy BN, Kurman RJ, et al: Relationship between surgical-pathologic risk factors and outcome in clinical stage 1 and II carcinoma of the endometrium: A gynecologic oncology group study, Gynecol Oncol 1991;40:55-65.
4. Henderson BE, Ross PK, Pike MC, Casagrande JT: Endogenous hormones as a major factor in human cancer, Cancer Res 1982;42:3232- 3239.
5. International Agency for Research on Cancer, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: 21 Sex Hormones (II), Lyon, IARC, 1979, pp 173-221.
6. Weisz J, Bui QD, Roy D, Liehr JG: Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: A potential pathway of metabolic activation of estrogens, Endocrinology 1992;131:655-661.
7. Liehr JG, Fang WF, Sirbasku DA, Ulubelcn AA: Carcinogenicity of catechol estrogens in Syrian hamsters, J Steroid Biochem 1986:24:353- 356.
8. Liehr JG, Roy D: Free radical generation by redox cycling of estrogens, Free Radic Biol Med 1986.8:415-423.
9. Metzler M, McLachlan JA: Oxidative metabolism of dicthylstilbestc-rol and steroidal estrogens as a potential factor in their fctotoxicity; in Ncubert D, Merker HJ, Nau H, Langman J (eds): Role for Pharmacokinetics in Prenatal and Perinatal Toxicology, Stuttgart, Thieme, 1978, pp 157-163.
10. Liehr JG, DaGue BB, Ballatore AM, Sirbasku DA: Multiple roles of estrogen in estrogen-dependent renal clear-cell carcinoma of Syrian hamster; in Sato GH, Pardee AB, Sirbasku DA (eds): Cold Spring Harbor Conference on Cell Proliferation, Cold Spring Harbor, Cold Spring Harbor Laboratory, 1982, pp 445-457.
11. Liehr JG, Ulubelcn AA, Stobcl HW: Cytochrome P450-mcdiated redox cycling of estrogens, J Biol Chem l’986;36:16865-16870.
12. Han X, Liehr JG: DNA singlestrand breaks in kidneys of Syrian hamsters treated with steroidal estrogens: Hormone-induced free radical damage preceding renal malignancy, Carcinogenesis 1994:15: 997-1000.
13. Mendelsohn ME, Karas RH: Estrogen and the blood vessel wall (review), Curr Opin Cardiol 1994:9: 619-626.
14. Gliscard V, Miller VM, Vanhoutte PM: Effect of 17β-estradiol on endothelium-dependent responses in the rabbit, J Pharmacol Exp Thcr 1988; 244:19-22.
15. Gliscard V, Flavahan NA: Vanhoutte PM: Alpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17p-estradiol, J Pharmacol ExpTher 1987;240:466-470.
16. Van Buren GA, Yang D, Clark KE: Estrogen-induced uterine vasodilation is antagonized by L-nitroargin-ine methylestcr, an inhibitor of nitric oxide synthesis, Am J Obstet Gynecol 1992:167:828-833.
17. Hayashi T, Fukuto JM, Ignarro U, Chaudhuri G: Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: Implications for atherosclerosis, Proc Natl Acad Sci USA 1992;89: 11259-11263.
18. Conrad KP, Joffe GM, Kruszyna H, Rochelle LG, Smith RP, Chavez JE, Mosher MD: Identification of increased nitric oxide biosynthesis during pregnancy in rats, FASEB J 1993;7:566-571.
19. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S: Induction of calcium-dependent nitric oxide synthases by sex hormones, Proc Natl Acad Sci USA 1994:91:5212.
20. Marietta MA: Nitric oxide synthase: Aspects concerning structure and catalysis, Cell 1994:78:927-930.
21. Schmidt HH, Walter U: NO at work (review), Cell 1994;78:919-925.
22. Ohshima H, Bartsch H: Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis, Mutat Res 1994:305:253-264.
23. Mirvish SS: Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposure to NOC, Cancer Lett 1995; 93:17-48.
24. Hsu SM, Rainc L, Fanger H: The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxi-dase techniques: A comparison between ABC and unlabelled antibody (PAP procedures), J Histochem Cy-tochem 1981;29:577-581.
25. Rcinartz JJ, George E, Lindgren BR, Niehans GA: Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2, in endometrial carcinoma and correlation with survival and known predictors of survival, Hum Pathol 1994;25:1075-1083.
26. Lukes AS, Kohler MF, Picpcr CF, Kerns BJ, Bentley R, Rodriguez GC, Soper JT, Clarkc-Pcarson DL, Bast CR Jr, Berchuck A: Multivariant analysis of DNA ploidy, p53, and HER-2/ncu as prognostic factors in endometrial cancer, Cancer 1994; 73:2380-2385.
27. Fujimoto I, Shimizu Y, Hirai Y, Chen JT, Teshima H, Hasumi K, Masubuchi K, Takahashi M: Studies on ras oncogene activation in endometrial carcinoma, Gynecol Oncol 1993:48:196-202.
28. Figueroa JP, Massmann GA: Estrogen increases nitric oxide synthase activity in the uterus of nonpregnant sheep, Am J Obstet Gynecol 1995; 173:1539-1545.
29. Thomsen LL, Lawton FG, Knowles RG, Bccslcy JE, Riveros-Moreno V, Moncada S: Nitric oxide synthase activity in human gynecologic cancer, Cancer Res 1994:54:1352- 1354.
30. Thomsen LL, Miles DW, Happer-ficld L, Bobrow LG, Knowles RG, Moncada S: Nitric oxide synthase activity in human breast cancer, Br J Cancer 1995;72:41-44.
31. Edwards P, Cendan JC, Topping DB, Moldawer LL, MacKay S, Copeland EM, Lind DS: Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo, J SurgRes 1996:63:49-52.
32. Bredt DS, Ferris CD, Snyder SH: Nitric oxide synthase regulatory sites, Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase: Identification of flavin and calmodulin binding sites, J Biol Chem 1992:267: 10976-10981.
33. Michel T, Li GK, Busconi L: Phosphorylation and subcellular translocation of endothelial nitric oxide synthase, Proc Natl Acâd Sci USA 1993:90:6252-6256.
34. Nathan C, XicQ: Regulation of biosynthesis of nitric oxide, J Biol Chem 1994;269:13725-13728.
35. O'Brien AJ, Young HM, Povcy JM, Furness JB: Nitric oxide synthase is localized predominantly in the Gol-gi apparatus and cytoplasmic vesicles of vascular endothelial cells, Histochemistry 1995;103:221-225.
36. Robinson LJ, Michel T: Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting, Proc Nat Acad Sci USA 1995:92:11776-11780.