The ursodeoxycholic acid-p-aminobenzoic acid deconjugation test, a new tool for the diagnosis of bacterial overgrowth syndrome

European Journal of Gastroenterology and Hepatology

Volumn 9, Issue 7, 1997, Pages 679-682

  Kiss, Zsuzsanna F ^a   Wölfling, János ^b   Csáti, Sándor ^a   Nagy, Ferenc ^a   Wittmann, Tibor ^a   Schneider, Gyula ^b   Lonovics, János ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Bacterial fermentative processes of bile acids; Bacterial overgrowth; Non invasive diagnostic test

Indexed keywords

AMINOBENZOIC ACID DERIVATIVE; LACTOSE; LACTULOSE; NITROIMIDAZOLE DERIVATIVE; TINIDAZOLE; URSODEOXYCHOLIC ACID DERIVATIVE;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL OVERGROWTH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DRUG EFFICACY; ENTEROPATHY; FEMALE; HUMAN; HYDROGEN BREATH TEST; INTERMETHOD COMPARISON; LOADING TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; URINARY EXCRETION;

EID: 0030745832     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199707000-00006     Document Type: Article

References (24)

1. Simon GL, Gorbach SJ: The human intestinal microflora. Dig Dis Sci 1986, 31:147S-162S.
2. Gray GM: Carbohydrate digestion and absorption. Gastroenterology 1970, 58:96-107.
3. 2) measurements to quantitative carbohydrate absorption. J Clin Invest 1972, 51:1219-1225.
4. 2 Breath test, a diagnostic method used in carbohydrate malabsorption. Orv Hetil 1981, 122:2039-2040.
5. 2 breath test. Orv Hetil 1983, 124:67-69.
6. 2 breath test in the cases of lactose malabsorption in adult. Magyar Belorv Arch 1988, 41:224-228.
7. Hill MJ, Drasar BS: Degradation of bile salts by human intestinal bacteria. Gut 1968, 9:22-27.
8. Fromm H, Hofmann AF: Breath test for altered bile-acid metabolism. Lancet 1971, ii:621-625.
9. Sherr HP, Sasaki Y, Newman A: Detection of bacterial deconjugation of bile salts by convenient breath-analysis technic. N Engl J Med 1971, 285:656-661.
10. Maeda Y, Takahashi M, Tashiro H, et al.: The rapid evaluation of intestinal bacterial growth using a conjugate of ursodeoxycholic acid with para-aminobenzoic acid. J Pharmacobio-Dyn 1989, 12:272-280.
11. Bergström S, Norman A: Synthesis of conjugated bile acids. Acta Chem Scand 1953, 7:1126-1127.
12. Levitt MD, Donaldson RM: Use of respiratory hydrogen to detect carbohydrate malabsorption. J Lab Clin Med 1970, 75:937-945.
13. Takahashi M, Maeda Y, Tashiro H, et al.: Basic studies on ursodeoxycholyl-para-aminobenzoic acid for evaluation of intestinal microflora. Scand J Gastroenterol 1991, 26:577-588.
14. Bratton AC, Marshall EK: A new coupling component for sulfanilamide determination. J Biol Chem 1939, 128:537-541.
15. Smith HW, Finkelstein N, Aliminosa L, et al.: The renal clearance of substituted hippuric acid derivates and other aromatic acids in dog and man. J Clin Invest 1945, 24:388-404.
16. 14C)bile acid breath test in patients with small-intestine bacterial overgrowth. Dig Dis Sci 1980, 25:53-58.
17. Metz GL, Gassull MA, Drasar BS, etf al.: Breath hydrogen test for small intestinal bacterial colonisation. Lancet 1976, i:668-669.
18. Gorbach SL, Tabaqchali S: Bacteria, bile and the small bowel. Gut 1969, 10:963-972.
19. Reddy BS, Engle A, Simi B, et al.: Effect of dietary fiber on colonic bacterial enzymes and bile acids in relation to colon cancer. Gastroenterology 1992, 102:1475-1482.
20. Hill MJ: The role of colon anaerobes in the metabolism of bile acids and steroids, and its relation to colon cancer. Cancer 1975, 36:2387-2400.
21. Arvantakis C, Longnecker MP, Folscroft J: Characterization of p-aminobenzoic acid transport across the rat intestine. J Lab Clin Med 1978, 91:467-472.
22. Maeda Y: Hydrolysis and absorption of a conjugate of ursodeoxycholic acid with para-aminobenzoic acid. J Pharmacobio-Dyn 1989, 12:744-753.
23. Kiss ZF, Wölfling J, Csáti S, et al.: Diagnostic value of ursodeoxycholyl-paraaminobenzoic acid (UDCA-PABA) test in contaminated small bowel syndrome (CSBS) [abstract]. Z Gastroenterol 1995, 33:286.
24. Takahashi M, Konishi T, Maede Y, et al.: Use of conjugate of disulphated ursodeoxycholic acid with p-aminobenzoic acid for detection of intestinal bacteria Gut 1993, 34:823-828.