Cardiovascular actions of chronic intracerebroventricular administration of metformin in normotensive rats

Pharmacology and Toxicology

Volumn 81, Issue 1, 1997, Pages 7-12

  Andersen, Ditte ^a   Haugan, Ketil ^a   Sørensen, Anne Mette ^a   Christensen, Sten ^a   Petersen, Jørgen Søberg ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEART RATE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030745179     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00023.x     Document Type: Article

References (33)

1. Anderson, E. A. & A. L. Mark: The vasodilator action of insulin: implications for the insulin hypothesis in hypertension. Hypertension 1993, 21, 136-141.
2. Bailey, C. J. & R. C. Turner: Metformin. New Engl. J. Med. 1996, 334, 574-579.
3. Calle-Pascual, A. L., J. Garcia-Honduvilla, P. J. Martin-Alvarez, E. Vara, J. R. Calle, M. E. Munguira & J. P. Maranes: Comparison between acarbose, metformin, and insulin treatment in type-2 diabetic patients with secondary failure to sulphonylurea treatment. Diabete et Metabolisme 1995, 21, 256-260.
4. Campbell, I. W., C. Duncan, N. W. Patton, T. Broadhead, G. T. Tucker & H. F. Woods: The effect of metformin on glycemic control, intermediary metabolism and blood pressure in non-insulin-dependent diabetes mellitus. Diabet. Med. 1987, 4, 337-341.
5. Chan, J. C. N., B. Tomlinson, J. A. J. H. Critchley, C. S. Cockram & R. J. Walden: Metabolic and hemodynamic effects of metformin and glibenclamide in normotensive NIDDM patients. Diabetes Care 1993, 16, 1035-1038.
6. De Fronzo, R. A., N. Barzilai & D. C. Simonson: Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J. Clin. Endocrin. Metab. 1991, 73, 1294-1301.
7. De Fronzo, R. A., A. M. Goodman and the Multicenter Metformin Study Group: Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. New Engl. J. Med. 1995, 333, 541-549.
8. DiBona, G. F.: Renal neural mechanisms in salt-sensitive hypertension. Blood Pressure 1995, 4(suppl. 2), 81-87.
9. Giugliano, D., N. De Rosa, G. De Maro, R. Marfella, R. Acampora, R. Buoninconti & F. D'Onofrio: Metformin for obese, insulin-treated diabetic patients: improvement of glycemic control and reduction of metabolic risk factors. Diabetes Care 1993a, 16, 1387-1390.
10. Giugliano, D., N. De Rosa, G. Di Maro, R. Marfella, R. Acampora, R. Buininconti & F. D'Onofrio: Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women. Diabetes Care 1993b, 16, 1387-1390.
11. Gudbjörnsdottir, S., P. Friberg, M. Elam, S. Attvall, P. Lönnroth & B. G. Wallin: The effect of metformin and insulin on sympathetic nerve activity, norepinephrine spillover and blood pressure in obese, insulin resistant, normoglycemic, hypertensive men. Blood Pressure 1994, 3, 394-403.
12. Haupt, E., B. Knick, T. Koschinsky, H. Liebermeister, J. Schneider & H. Hirche: Oral diabetic combination therapy with sulphonylureas and metformin. Diabete Metab. 1991, 17, 224-231.
13. Hermann, L. S., B. Schersten, P. Bitzen, T. Kjellstrom, F. Lindgarde & A. Melander: Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations: a double blind controlled study. Diabetes Care 1994, 17, 1100-1109.
14. Janssen, B. J. A., C. M. Tyssen & H. A. J. Struyker-Boudier: Modification of circadian blood pressure and heart rate variability by five different antihypertensive agents in spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 1991, 17, 494-503.
15. Johnson, A. K. & P. M. Gross: Sensory circumventricular organs and brain homeostatic pathways. FASEB J. 1993, 7, 678-686.
16. Koepke, J. P. & G. F. DiBona: High sodium intake enhances renal nerve and antinatriuretic responses to stress in spontaneously hypertensive rats Hypertension. 1985, 7, 357-363.
17. Kotchen, T. A.: Attenuation of hypertension by insulin-sensitizing agents. Hypertension. 1996, 28, 219-223.
18. Landin, K., L. Tengborn & U. Smith: Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factors J. Intern. Med. 1991, 229, 181-187.
19. Landin, K., L. Tengborn & U. Smith: Metformin and metoprolol CR treatment in non-obese men J. Int. Med. 1994, 235, 335-341.
20. Montaguti, U., D. Celin, C. Ceredi, & G. C. Descovich: Efficacy of the long-term administration of metformin in hyperlipidaemic patients. Res. Clin. Forums. 1979, 1, 95-103.
21. Morgan, D. A. & A. L. Mark: Contrasting effects of metformin and ciglitazone on sympathetic nerve responses to insulin. FASEB J. 1993, 7, A653.
22. Muntzel, M., A. Abe & J. S. Petersen: Effects of adrenergic, cholinergic, and ganglionic blockade on acute depressor responses to metformin in spontaneously hypertensive rats. J. Pharmacol. Exp. Therap. 1997, 281, 618-623.
23. Petersen, J. S., M. Shalmi, H. R. Lam, & S. Christensen: Renal response to furosemide in conscious rats: effects of acute instrumentation and peripheral sympathectomy. J. Pharmacol. Exp. Therap. 1991, 258, 1-7.
24. Petersen, J. S. & G. F. DiBona: Acute sympathoinhibitory responses to metformin in spontaneously hypertensive rats. Hypertension 1996, 27, 619-625.
25. Petersen, J. S. & G. F. DiBona: Central metformin administration inhibits sympathoexcitatory responses to air jet stress in spontaneously hypertensive rats. J. Hypertension 1997, 15, 285-291.
26. Petersen, J. S., W. Liu, D. R. Kapusta & K. V. Varner: Metformin inhibits ganglionic neurotransmission in renal nerves. Hypertension 1997, 29, 1173-1177.
27. Semplicini, A., S. Del Prato, M. Giusto, M. Campagnolo, P. Palatini, G. P. Rossi, R. Valle, M. Dorella, G. Albertini & A. C. Pessina: Short-term effects of metformin on insulin sensitivity and sodium homeostasis in essential hypertensives. J. Hypertens 1993, 11(Suppl. 5), S276-S277.
28. United Kingdom Prospective Diabetes Study Group.: United Kingdom prospective diabetes study (UKPDS) 13: Relative efficacy of randomly allowed diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years Brit. J. Med. 1995, 310, 83-88.
29. Vague, P., I. Juhan-Vague, M. C. Alessi, C. Badier & J. Valadier: Metformin decreases the high plasminogen activator inhibition capacity, plasma insulin and triglyceride levels in non-diabetic obese subjects. Thromb. Haemost. 1987, 57, 326-328.
30. Velazquez, E. M., S. Mendoza, T. Hamer, F. Sosa & C. J. Glueck: Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994, 43, 647-654.
31. Verma, S., S. Bhanot & J. H. McNeil: Metformin decreases plasma insulin levels and systolic blood pressure in spontaneously hypertensive rats. Amer. J. Physiol. 1994a, 267, H1250-H1253.
32. Verma, S., S. Bhanot & J. H. McNeil: Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats. J. Pharmacol. Exp. Therap. 1994b, 271, 1334-1337.
33. Zhang, H. Y., S. R. Reddy & T. A. Kotchen: Antihypertensive effect of pioglitazone is not invariably associated with increased insulin sensitivity. Hypertension 1994, 25, 106-110.