Human immunodeficiency virus glycoprotein-specific CD4+ cytotoxic T lymphocytes are involved in two types of cytotoxicity: Antigen-specific and cell-cell fusion-related cell lysis

AIDS Research and Human Retroviruses

Volumn 13, Issue 12, 1997, Pages 1017-1021

  Ehret, Robert ^a   Heinkelein, Martin ^a   Siliciano, Robert F ^b   Jassoy, Christian ^a,c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GLYCOPROTEIN GP 41; VIRUS GLYCOPROTEIN;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL FUSION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION;

EID: 0030745048     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1997.13.1017     Document Type: Article

References (23)

1. Yap KL, Ada GL, and McKenzie IFC: Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature (London) 1978;273:238-239.
2. Sethi KK, Omata Y, and Schnewer KE: Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of virus-specific and H-2 restricted cytotoxic T lymphocytes. J Gen Virol 1983;64:443-447.
3. Oldstone MBA:Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature (London) 1986;321:239-243.
4. Johnson RP and Walker BD: Cytotoxic T lymphocytes in HIV infection: Responses to structural proteins. Curr Topics Microbiol Immunol 1994;189:35-62.
5. Siliciano RF, Lawton T, Knall C, Karr RW, Berman P, Gregory T, and Reinherz EL: Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV-sequence variation and a mechanism for CD4+ cell depletion. Cell 1988;54:561-575.
6. Orentas RJ, Hildreth JEK, Obah E, Polydefkis M, Smith GE, Clements ML, and Siliciano RF: An HIV envelope protein vaccine induces CD4+ cytolytic cells active against HIV-infected cells. Science 1990;248:1234-1237.
7. Hammond SA, Bollinger RC, Stanhope PE, Quinn TC, Schwartz D, Clements ML, and Siliciano RF: Comparative clonal analysis of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HIV-1 vaccines. J Exp Med 1992; 176:1531-1542.
8. Cooney EL, McElrath MJ, Corey L, et al.: Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein. Proc Natl Acad Sci USA 1993;90:1882-1886.
9. Stanhope PE, Liu AY, Pavlat W, Pitha P, Clements ML, and Siliciano RF: An HIV-1 envelope protein vaccine induces a functionally complex human CD4+ T cell response that includes virus-specific cytolytic T lymphocytes. J Immunol 1993;150:4672-4678.
10. Miskovsky EP, Liu AY, Pavlat W, et al.: Studies of the mechanism of cytolysis by HIV-I specific CD4+ human CTL clones induced by candidate AIDS vaccines. J Immunol 1994;153:2787-2799.
11. Heinkelein M, Sopper S, and Jassoy C: Contact of human immunodeficiency virus type 1-infected and uninfected CD4+ T lymphocytes is highly cytolytic for both cells. J Virol 1995;69:6925-6931.
12. Heinkelein M, Euler-König I, Klinker H, Rückle-Lanz H, and Jassoy C: Lysis of human immunodeficiency virus type 1 antigen-expressing cells by CD4 and CD8 T cells ex vivo. J Infect Dis 1996; 174:209-213.
13. Johnson RP, Hammond SA, Trocha A, Siliciano RF, and Walker BD: Induction of major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine. J Virol 1994;68:3145-3153.
14. Earl PL, Koenig S, and Moss B: Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: Analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses. J Virol 1991;65:31-41.
15. Rowell JF, Stanhope PE, and Siliciano RF: Endocytosis of endogenously synthesized HIV-1 envelope glycoprotein. J Immunol 1995;155:473-488.
16. Koup RA, Pikora CA, Luzuriaga K, Brettler DB, Day ES, Mazzara GP, and Sullivan JL: Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus Gag antigens in infected persons: In vitro quantitation of effector cell populations with p17 and p24 specificities. J Exp Med 1991;174:1593-1600.
17. Walker BD: HIV-1-specific cytotoxic T lymphocytes. In: Techniques in HIV Research (Aldovini A and Walker B, eds.). Stockton Press, New York, 1990;pp. 201-209.
18. Chesebro B and Wehrly K: Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity. J Virol 1988;62:3779-3788.
19. Siliciano RF: The role of CD4 in HIV envelope-mediated pathogenesis. Curr Topics Microbiol Immunol 1996;205:159-179.
20. Curiel TJ, Wong JT, Gorczyca PF, Schooley RT, and Walker BD: CD4+ human immunodeficiency virus type 1 (HIV-1) envelope-specific cytotoxic T lymphocytes derived from the peripheral blood cells of an HIV-1-infected individual. AIDS Res Hum Retroviruses 1993;9:61-68.
21. Callahan KM, Rowell JF, Soloski MJ, Machamer CE, and Siliciano RF: HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes. J Immunol 1993;151:2928-2942.
22. Kundu SK, Katzenstein D, Moss LE, and Merigan TC: Enhancement of human immunodeficiency virus (HIV)-specific CD4+ and CD8+ cytotoxic T-lymphocyte activities in HIV-infected asymptomatic patients given recombinant gp160 vaccine. Proc Natl Acad Sci USA 1992;89:11204-11208.
23. Nardelli B, Gonzales CJ, Schechter M, and Valentine FT: CD4+ blood lymphocytes are rapidly killed in vitro by contact with autologous human immunodeficiency virus-infected cells. Proc Natl Acad Sci USA 1995;92:7312-7316.