X-ray diffraction and far-UV CD studies of filaments formed by a leucine-rich repeat peptide: Structural similarity to the amyloid fibrils of prions and Alzheimer's disease β-protein

FEBS Letters

Volumn 412, Issue 2, 1997, Pages 397-403

  Symmons, Martyn F ^a   Buchanan, Sean G St C ^a,c   Clarke, David T ^b   Jones, Gareth ^b   Gay, Nicholas J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b DARESBURY LABORATORY   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Leucine rich repeat filament; Prion amyloid; Stabilization; X ray diffraction

Indexed keywords

AMYLOID BETA PROTEIN; LEUCINE;

ALZHEIMER DISEASE; ARTICLE; ELECTRON MICROSCOPY; HUMAN; PRION; PRIORITY JOURNAL; PROTEIN STRUCTURE; ULTRAVIOLET SPECTROSCOPY; X RAY DIFFRACTION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; CIRCULAR DICHROISM; HUMANS; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; PRIONS; PROTEIN CONFORMATION; PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; X-RAY DIFFRACTION;

EID: 0030744878     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00809-0     Document Type: Article

References (20)

1. Inouye, H., Fraser, P.E. and Kirschner, D.A. (1993) Biophys. J. 64, 502-519.
2. Nguyen, J.T., Inouye, H., Baldwin, M.A., Fletterick, R.J., Cohen, F.E., Prusiner, S.B. and Kirschner, D.A. (1995) J. Mol. Biol. 252, 412-422.
3. Buchanan, S.G.S.C. and Gay, N.J. (1996) Prog. Biophys. Mol. Biol. 65, 1-44.
4. Kobe, B. and Deisenhofer, J. (1993) Nature 366, 751-756.
5. Kobe, B. and Deisenhofer, J. (1995) Curr. Opin. Struct. Biol. 5, 409-416.
6. Yoder, F. and Jurnak, F. (1995) FASEB J. 9, 335-342.
7. Gay, N.J., Packman, L.C., Weldon, M.A. and Barna, J.C.J. (1991) FEBS Lett. 291, 87-91.
8. Denny, R.C. (1993) The CCP13 Newsletter No. 2, Daresbury Laboratory, Warrington, UK.
9. Lansbury, P.J. and Jarret, J.T. (1993) Cell 73, 1055-1058.
10. Geddes, A.J., Parker, K.D., Atkins, E.D.T. and Beighton, E. (1968) J. Mol. Biol. 32, 343-358.
11. Kirschner, D.A., Inouye, H., Duffy, L.K., Sinclair, A., Lind, M. and Selkoe, D.J. (1987) Proc. Natl. Acad. Sci. USA 84, 6953-6957.
12. Kirschner, D.A., Abraham, C. and Selkoe, D.J. (1986) Proc. Natl. Acad. Sci. USA 83, 503-507.
13. Fraser, P.E., Nguyen, J.T., Surewicz, E.K. and Kirschner, D.A. (1991) Biophys. J. 60, 1190-1201.
14. Perutz, M.F., Johnson, T., Suzuki, M. and Finch, J. (1994) Proc. Natl. Acad. Sci. USA 91, 5355-5358.
15. Goldfarb, L.G., Petersen, R.B., Tabaton, M., Brown, P., Leblanc, A.C., Montagna, P., Cortelli, P., Julien, J., Vital, C., Pendlebury, W.W., Haltia, M., Wills, P.R., Hauw, J.J., McKeever, P.E., Monari, L., Schrank, B., Swergold, G.D., Autiliogambetti, L., Gajdusek, D.C., Lugaresi, E. and Gambetti, P. (1992) Science 258, 806-808.
16. Westaway, D., Zuliani, V., Cooper, C.M., DaCosta, M., Neuman, S., Jenny, A.L., Detwiler, L. and Prusiner, S.B. (1994) Genes Dev. 8, 959-969.
17. Soto, C., Castano, E.M., Frangione, B. and Inestrosa, N.C. (1995) J. Biol. Chem. 270, 3063-3067.
18. Ghiso, J., Jensson, O. and Frangione, B. (1986) Proc. Natl. Acad. Sci. USA 83, 2974-2978.
19. Maury, C.P.J. and Nurmiaho, E.L. (1992) Biochem. Biophys. Res. Comm. 183, 227-231.
20. Aggeli, A., Bell, M., Boden, N., Keen, J.N., Knowles, P.F., McLeish, T.C.B., Pitkeathly, M. and Radford, S.E. (1997) Nature 386, 259-262.