Rapid Disappearance of AMLI/ETO Fusion Transcripts in Patients with t(8;21) Acute Myeloid Leukemia Following Bone Marrow Transplantation and Chemotherapy

Leukemia and Lymphoma

Volumn 26, Issue 42006, 1997, Pages 141-152

  Sakata, Naoki ^a   Okamura, Takayuki ^a   Inoue, Masami ^a   Yumura Yagi, Keiko ^a   Hara, Junichi ^b   Tawa, Akio ^b   Kodera, Urara ^c   Sako, Masahiro ^d   Kawa ha, Keisei ^a  

^a RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

^d OSAKA CITY GENERAL HOSPITAL   (Japan)

Author keywords

acute myeloid leukemia (AML); AML1 ETO; chimeric RNA; minimal residual disease (MRD); RT PCR; t(8; 21)(q; 22; q22)

Indexed keywords

PIRARUBICIN; RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CHIMERA; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; MALE; MINIMAL RESIDUAL DISEASE; PRESCHOOL CHILD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD;

ADOLESCENT; ANTINEOPLASTIC AGENTS; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 8; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LEUKEMIA, MYELOID; MALE; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSLOCATION, GENETIC;

EID: 0030744508     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428199709109169     Document Type: Article

References (27)

1. Borrow H., Goddard A. D., Sheer D., Solomon E. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 1990; 249: 1577 – 1580
2. Chang K. S., Fan Y. H., Stass S. A., Estey E. H., Wang G., Trujillo J. M., Erickson P., Drabkin H. A. Expression of AMLI-ETO fusion transcripts and detection of minimal residual disease in t(8;21)-positive acute myeloid leukemia. Oncogene 1993; 8: 983 – 988
3. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 1987; 162: 156 – -159
4. De The H., Chomienne C., Lanotte M., Degos L., Dejean A. The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 1990; 347: 558 – 561
5. Diverio D., Pandolfi P. P., Biondi A., Avvisati G., Peti M. C., Mandelli F., Pelicci P. G., Coco F. Absence of reverse transcription-polymerase chain reaction detectable residual disease in patients with acute promyelocytic leukemia in long-term remission. Blood 1993; 82: 3556 – 3559
6. Downing J. R., Head D. R., Curcio-Brint A. M., Husshof M. G., Motroni T. A., Raimondi S. C., Carroll A. J., Drabkin H. A., Wilman C., Theil K. S., Civin C. I., Erickson P. An AMLI/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood 1993; 81: 2860 – 2865
7. Erickson P., Gao J., Chang K. S., Look T., Whisenant E., Raimondi S., Lasher R., Trujillo J. M., Rowley J., Drabkin H. Identification of breakpoint in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AMLI/ETO, with similarity to Drosophila Segmentation gene, runt. Blood 1992; 80: 1825 – 1831
8. Kamps M. P., Murre C., Sun X. H., Baltimore D. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 1990; 60: 547 – 555
9. Kitchingman G. Residual disease detection in multiple follow-up samples in children with acute lymphoblastic leukemia. Leukemia 1994; 8: 395 – 401
10. Kozu T., Miyoshi H., Shimizu K., Maseki N., Kaneko Y., Asou H., Kamada N., Ohki M. Junctions of the AML1/MTG8(ETO) fusion are constant in t(8:21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood 1993; 82: 1270 – 1276
11. Kusec R., Laczika K., Knobl P., Friedl J., Greinix H., Kahls P., Linkesch W., Schwarzinger I., Miterbauer G., Purtscher B., Haas O. A., Lehner K., Jaeger U. AMLI/ETO fusion mRNA can be detected in remission blood samples of all patient with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation. Leukemia 1994; 8: 735 – 739
12. Laczika K., Mitterbauer G., Korninger L., Knobl P., Schwarzinger I., Kapiotis S., Haas O. A., Kyrie P. A., Pont J., Oehler L., Purtscher B., Thalhammer F., Lechner K., Jaeger U. Rapid achievement of PML-RARa polymerase chain reaction (PCR)-negativity by combined treatment with all-trans-retinoic acid and chemotherapy in acute promyelocytic leukemia; a pilot study. Leukemia 1994; 8: 1 – 5
13. Lee M., Khouri I., Champlin R., Kantarjian H., Talpaz M., Tujillo J., Freireich E., Deisseroth A., Stass S. Detection of minimal residual disease by polymerase chain reaction of bcr/abl transcripts in chronic myelogenous leukemia follows allogeneic bone marrow transplantation. Br. J. Hematol 1992; 82: 708 – 714
14. Mallentin J. D., Murre C., Donlon T. A., McCaw P. S., Smith S. D., Carroll A. J., McDonald M. E., Baltimore D., Cleary M. L. The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias. Science 1989; 246: 379 – 382
15. Maruyama F., Stass S. A., Estey E. H., Cork A., Hirano M., Ino T., Freireich E. J., Yang P., Chang K. S. Detection of AMLI/ETO fusion transcript as a tool for diagnosing t(8:21) positive acute myelogenous leukemia. Leukemia 1994; 8: 40 – 45
16. Maseki N., Miyoshi H., Shimizu K., Homma C., Ohki M., Sakurai M., Kaneko Y. The 8:21 chromosome translocation in acute myeloid leukemia is always detectable by molecular analysis using. AMLI, Blood 1993; 81: 1573 – 1579
17. Miyamura K., Tahara T., Tanimoto M., Morishita Y., Kawashima K., Morishima Y., Saito H., Tsuzuki S., Takeyama K., Kodera Y., Matsuyama K., Hirabayashi N., Yamada H., Naito K., Imai K., Sakamaki H., Asai O., Mizutani S. Long persistent bcr-abl positive transcript detected by polymerase chain reaction after marrow transplant for chronic myelogenous leukemia without clinical relapse: A study of 64 patients. Blood 1993; 81: 1089 – 1093
18. Miyoshi H., Shimizu K., Kozu T., Maseki N., Kaneko Y., Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia ara clustered within a limited region of a single gene. AMLI, Proc. Natl. Acad. Sci. USA 1991; 88: 10431 – 10434
19. Nakajima-Lijima S., Hamada H., Reddy P., Kakunaga T. Molecular structure of the human cytoplasmic b-actin gene: Interspecies homology of sequence in the intros. Proc. Natl. Acad. Sci. USA 1985; 82: 6133 – 6137
20. Nucifora G., Birn D. J., Erickson P., Gao J., LeBeau M. M., Drabkin H. A., Rowley D. Detection of DNA rearrangement in the AMLI and ETO loci and of an AMLI/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia. Blood 1993; 81: 883 – 888
21. Nucifora G., Larson R. A., Rowley J. D. Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission. Blood 1993; 82: 712 – 715
22. Privitera E., Lucicano A., Ronchetti D., Alico M., Santostasi T., Basso G., Biondi A. Molecular variants of the 1;19 chromosomal translocation in pediatric acute lymphoblastic leukemia (ALL). Leukemia 1994; 8: 554 – 559
23. Sakata N., Hara J., Osugi Y., Kurahashi H., Inoue M., Yumura-Yagi K., Tawa A., Kawa-Ha K. Genotypic typing using amplified variable number of tandem repeats with polymerase chain reaction following allogeneic bone marrow transplntation. Jpn. J. Pediatr. Hematol 1992; 6: 468 – 472
24. Satake N., Maseki N., Kozu T., Sakashita A., Kobayashi H., Sakurai M., Ohki M., Kaneko Y. Disappearance of AML1-MTG8 (ETO) fusion transcript in acute myeloid leukemia patients with t(8;21) in long-term remission. Br. J. Haematol 1995; 91: 892 – 898
25. Shimizu K., Miyoshi H., Kozu T., Nagata J., Enomoto K., Maseki N., Kaneko Y. Consistent disruption of the AMLI gene occurs within a single intron in the (8;21) chromosomal translocation. Cancer Research 1992; 52: 6945 – 6948
26. Swirsky D. M., Li Y. S., Matthews J. G., Flemans R. J., Rees J. K. H., Hayhoe F. G.J. 8;21 translocation in acute granulocytic leukaemia: Cytological, cytochemical and clinical features. Br. J. Haematol 1984; 56: 199
27. Zahng T., Hillion J., Tong J. H., Cao Q., Chen S. J., Berger R., Chen Z. AML-1 gene rearrangement and AMLI-ETO gene expression as molecular markers of acute myeloblastic leukemia with t(8;21). Leukemia 1994; 8: 729 – 734