The two component palladium catalyst system for intermolecular hydroamination of allenes

Tetrahedron Letters

Volumn 38, Issue 34, 1997, Pages 6071-6074

  Al Masum, Mohammad ^a,b   Meguro, Masaki ^a,b   Yamamoto, Yoshinori ^a,b  

^a Inst for Chemical Reaction Science   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYLAMINE DERIVATIVE;

ARTICLE; CATALYSIS; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030744311     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01370-1     Document Type: Article

References (26)

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15. In tosyl amine cases, when phenylallene : amine ratio was 1:1, isolated yield for 4a and 3j were 62% and 37% respectively and when allene : amine ratio was 2:1, isolated yield for 4a and 3j were 61% and 24% respectively.With allenes 1b and 1f, 1:1 ratio was used.
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17. 3 and dppf was employed 3a was obtained in lower yield (51%).
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26. One referee suggested that the role of acetic acid is to protonate the Pd-coordinated allene and facilitate nucleophilic attack by the amine.