Stimulus dependence of non-steroidal antiinflammatory drug potency in a cellular assay of prostaglandin H synthase-2

European Journal of Pharmacology

Volumn 331, Issue 1, 1997, Pages 79-85

  Hulkower, Keren I ^a   Otis, Ellen R ^a   Wernimont, Amy K ^a   Bell, Randy L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Non steroidal anti inflammatory drug; Prostaglandin H synthase 2; WISH cell

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; ANTIINFLAMMATORY AGENT; DEXAMETHASONE; FLOSULIDE; IBUPROFEN; INDOMETACIN; INTERLEUKIN 1BETA; ISOENZYME; MECLOFENAMIC ACID; NIMESULIDE; OKADAIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME IMMUNOASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; MODEL; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE INHIBITORS; DEXAMETHASONE; DINOPROSTONE; DRUG INTERACTIONS; HUMANS; IBUPROFEN; INDANS; INDOMETHACIN; INTERLEUKIN-1; MECLOFENAMIC ACID; NITROBENZENES; OKADAIC ACID; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030743796     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01029-7     Document Type: Article

References (31)

1. Barnett, J., Chow, J., Ives, D., Chiou, M., Mackenzie, R., Osen, E., Nguyen, B., Tsing, S., Bach, C., Friere, J., Chan, H., Sigal, E., Ramesha, C., 1994. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209, 130-139.
2. Bensadoun, A., Weinstein, D., 1976. Assay of proteins in the presence of interfering materials. Anal. Biochem. 70, 241-250.
3. Chan, C.-C., Boyce, S., Brideau, C., Ford-Hutchinson, A.W., Gordon, R., Guay, D., Hill, R.G., Li, C-S., Mancini, J., Penneton, M., Prasit, P., Rasori, R., Riendeau, D., Roy, P., Tagari, P., Vickers, P., Wong, E., Rodger, I.W., 1995. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J. Pharmacol. Exp. Ther. 274, 1531-1537.
4. Copeland, R.A., Williams, J.M., Giannaras, J., Nurnberg, S., Covington, M., Pinto, D., Pick, S., Trzaskos, J.M., 1994. Mechanism of selective inhibition of the inducible form of prostaglandin G/H synthase. Proc. Natl. Acad. Sci. USA 91, 11202-11206.
5. Cromlish, W.A., Payette, P., Culp, S.A., Ouellet, M., Percival, M.D., Kennedy, B.P., 1994. High level expression of active human cyclooxygenase-2 in insect cells. Arch. Biochem. Biophys. 314, 193-199.
6. 2 expressed in insect cells and present in human monocytes. J. Biol. Chem. 271, 6987-6997.
7. Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S., Otomo, S., 1994. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47, 55-59.
8. Hayflick, L., 1961. The establishment of a line (WISH) of human amnion cells in continuous cultivation. Exp. Cell Res. 23, 14-20.
9. Herschman, H.R., 1996. Prostaglandin synthase 2. Biochim. Biophys. Acta 1299, 125-140.
10. 2. Arthritis Rheum. 37, 653-661.
11. Hulkower, K.I., Otis, E.R., Li, J., Ennis, B.W., Cugier, D.J., Bell, R.L., Carter, G.W., Glaser, K.B., 1997. Induction of prostaglandin H synthase-2 and tumor necrosis factor-α in human amnionic WISH cells by various stimuli occurs through distinct intracellular mechanisms. J. Pharmacol. Exp. Ther. 280, 1065-1074.
12. Kargman, S., Wong, E., Greig, G.M., Falgueyret, J.-P., Cromlish, W., Ethier, D., Yergey, J.A., Riendeau, D., Evans, J.F., Kennedy, B., Tagari, P., Francis, D.A., O'Neill, G.P., 1996. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochem. Pharmacol. 52, 1113-1125.
13. Klein, T., Nusing, R.M., Pfeilschifter, J., Ullrich, V., 1994. Selective inhibition of cyclooxygenase 2. Biochem. Pharmacol. 48, 1605-1610.
14. Kujubu, D.A., Herschman, H.R., 1992. Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J. Biol. Chem. 267, 7991-7994.
15. Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
16. 2 is phosphorylated and activated by MAP kinase. Cell 72, 269-278.
17. Meade, E.A., Smith, W.L., DeWitt, D.L., 1992. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268, 6610-6614.
18. Meade, E.A., Smith, W.L., DeWitt, D.L., 1993. Expression of the murine prostaglandin (PGH) synthase-1 and PGH synthase-2 isozymes in cos-1 cells. J. Lipid Mediators 6, 119-129.
19. Menon, S.D., Guy, G.R., Tan, Y.H., 1995. Involvement of a putative protein-tyrosine phosphatase and IκBα serine phosphorylation in nuclear factor κB activation by tumor necrosis factor. J. Biol. Chem. 270, 18881-18887.
20. Mitchell, J.A., Akarasereenont, P., Thiemermann, C., Flower, R.J., Vane, J.R., 1994. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 90, 11693-11697.
21. 2 synthases. Chem. Biol. 2, 343-350.
22. O'Neill, G.P., Mancini, J.A., Kargman, S., Yergey, J., Kwan, M.Y., Falgueret, J.-P., Abramovitz, M., Kennedy, B.P., Ouellet, M., Cromlish, W., Culp, S., Evans, J.F., Ford-Hutchinson, A.W., Vickers, P.J., 1994. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by non-steroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. Mol. Pharmacol. 45, 245-254.
23. Ouellet, M., Percival, M.D., 1995. Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem. J. 306, 247-251.
24. Patrignani, P., Panara, M.R., Greco, A., Fusco, O., Natoli, C., Iacobelli, S., Cipollone, F., Ganci, A., Creminon, C., Maclouf, J., Patrono, C., 1994. Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J. Pharmacol. Exp. Ther. 271, 1705-1712.
25. Reitz, D.B., Li, J.J., Norton, M.B., Reinhard, E.J., Collins, J.T., Anderson, G.D., Gregory, S.A., Koboldt, C.M., Perkins, W.E., Seibert, K., Isakson, P.C., 1994. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors. J. Med. Chem. 37, 3878-3881.
26. Ristimaki, A., Garfinkel, S., Wessendorf, J., Maciag, T., Hla, T., 1994. Induction of cyclooxygenase-2 by interleukin-1α: evidence for post-transcriptional regulation. J. Biol. Chem. 269, 11769-11775.
27. Scheinman, R.I., Cogswell, P.C., Lofquist, A.K., Baldwin, A.S., 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270, 283-286.
28. Towbin, H., Staehelin, T., Gordon, J., 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
29. Vane, J.R., Botting, R.M., 1995. New insights into the mode of action of anti-inflammatory drugs. Inflamm. Res. 44, 1-10.
30. Ward, A., Brogden, R.N., 1988. Nimesulide: a preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states. Drugs 36, 732-753.
31. 2 and prostaglandin H synthase-2 by interleukin-1β in WISH cells is inhibited by dexamethasone. Prostaglandins 51, 107-124.