Synthesis of racemic 6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5- diones as antagonists of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid (AMPA) receptors

Journal of Medicinal Chemistry

Volumn 40, Issue 15, 1997, Pages 2424-2429

  Guzikowski, A P ^a   Whittemore, E R ^a   Woodward, R M ^a   Weber, E ^a   Keana, J F W ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7,8,9 TETRAHYDRO 3 HYDROXY 1H 1 BENZAZEPINE 2,5 DIONE DERIVATIVE; 7,8 DICHLORO 6,7,8,9 TETRAHYDRO 3 HYDROXY 1H 1 BENZAZEPINE 2,5 DIONE; 7,8 DICHLORO 6,7,8,9 TETRAHYDRO 3 HYDROXY 6 METHYL 1H 1 BEZAZEPINE 2,5 DIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; BENZAZEPINES; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE POTENTIALS; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM; XENOPUS;

EID: 0030743670     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960724e     Document Type: Article

References (27)