Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers

Thorax

Volumn 52, Issue 6, 1997, Pages 519-522

  O'Shaughnessy, T C ^a   Georgiou, P ^b   Howland, K ^b   Dennis, M ^b   Compton, C H ^b   Barnes, N C ^a  

^a LONDON CHEST HOSPITAL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Asthma; Leukotriene receptor antagonist; ONO 1078; Pranlukast; SB 205312

Indexed keywords

LEUKOTRIENE RECEPTOR BLOCKING AGENT; PRANLUKAST;

ARTICLE; ASTHMA; BRONCHUS REACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030743407     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.6.519     Document Type: Article

References (23)

1. Morris HR, Taylor GW, Piper PJ, Tippins JR. Structure of slow-reacting substance of anaphylaxis from guinea-pig lung. Nature 1980;285:104-6.
2. Drazen JM, Austen KF. Leukotrienes and airway responses. Am Rev Respir Dis 1987;136:985-8.
3. 4, increase the release of mucus from human airways in vitro. Am Rev Respir Dis 1982;126:449-51.
4. 4 after antigen challenge and in acute asthma and allergic rhinitis. Lancet 1989;i: 584-8.
5. Lee TH. Mechanism of bronchospasm in aspirin-sensitive asthma (editorial). Am Rev Respir Dis 1993;148:1442-3.
6. Kuehl FA Jr, DeHaven RN, Pong SS. Lung tissue receptors for sulfidopeptide leukotrienes. J Allergy Clin Immunol 1984;74:378-81.
7. Holroyde MC, Altounyan RE, Cole M, Dixon M, Elliott EV. Bronchoconstriction produced in man by leukotrienes C and D. Lancet 1981;ii:17-8.
8. Sladek K, Szczeklik A. Cysteinyl leukotrienes overproduction and mast cell activation in aspirin-provoked bronchospasm in asthma. Eur Respir J 1993;6:391-9.
9. 4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. Am Rev Respir Dis 1991;143: 1025-9.
10. Wenzel SE, Westcott JY, Larsen GL. Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. J Allergy Clin Immunol 1991;87:540-8.
11. 4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis 1990;142:112-9.
12. 4 in bronchial asthma. Eur Respir J 1992;5:693-9.
13. Arm JP, O'Hickey SP, Spur BW, Lee TH. Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. Am Rev Respir Dis 1989; 140:148-53.
14. 4 excretion in normal and asthmatic subjects. Am Rev Respir Dis 1993;148:1244-51.
15. Dahlen B, Kumlin M, Margolskee DJ, Larsson C, Blomqvist H, Williams VC, et al. The leukotriene-receptor antagonist MK-0679 blocks airway obstruction induced by lysine-aspirin in aspirin-sensitive asthmatics. Eur Respir J 1993; 6:1018-26.
16. Taylor IK, O'Shaughnessy KM, Fuller RW, Dollery CT. Effect of cysteinyl-leukotriene receptor antagonist ICI 204, 219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 1991;337:690-4.
17. Taniguchi Y, Tamura G, Honma M, Aizawa T, Maruyama N, Shirato K, et al. The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects. J Allergy Clin Immunol 1993;92:507-12.
18. Obata T, Okada Y, Motoishi M, Nakagawa N, Terawaki T, Aishita H. In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol 1992;60: 227-37.
19. 4 and antigen in vitro. Am Rev Respir Dis 1992;146:923-9.
20. Fujimura M, Sakamoto S, Kamio Y, Matsuda T. Effect of a leukotriene antagonist, ONO-1078, on bronchial hyperresponsiveness in patients with asthma. Respir Med 1993;87:133-8.
21. 4-induced bronchoconstriction in normal man. J Allergy Clin Immunol 1987;79:816-21.
22. Sterk PJ, Fabbri LM, Quanjer PhH, Cockcroft DW, O'Byrne PM, Anderson SD, et al. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Eur Respir J 1993; 6(Suppl 16):53-83.
23. 4 inhalation challenge in normal humans. Br J Clin Pharmacol 1985; 20:554P.