PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro

European Journal of Pharmacology

Volumn 332, Issue 2, 1997, Pages 161-165

  Huang, Lingqian ^a   Breakwell, Nicholas A ^a   Rowan, Michael J ^a   Anwyl, Roger ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

((R,S) methyl 4 tetrazolylphenylglycine); Hippocampus; Long term potentiation; mGlu receptor; MTPG; PCCG IV ((2S, 1'S, 2'S, 3'R) 2 (2'' carboxy 3' phenylcyclopropyl)glycine)

Indexed keywords

ALPHA METHYL 4 TETRAZOLYLPHENYLGLYCINE; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; HIPPOCAMPUS; IN VITRO STUDY; LONG TERM POTENTIATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALANINE; ANIMALS; CYCLOPROPANES; DENTATE GYRUS; EVOKED POTENTIALS, SOMATOSENSORY; GLYCINE; LONG-TERM POTENTIATION; MALE; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; TETRAZOLES;

EID: 0030742990     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01079-0     Document Type: Article

References (30)

1. Bashir, Z.I., Bortolotto, Z.A., Davies, C.H., Berrata, N., Irving, A.J., Seal, A.J., Henley, J.M., Jane, D.E., Watkins, J.C., Collingridge, G.L., 1993. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature 363, 347-350.
2. Behnisch, T., Fjodorov, K., Reymann, K.G., 1991. L-2-amino-3-phosphoproprionate blocks late synaptic long-term potentiation. Neuroreport 2, 386-388.
3. Bortolotto, Z.A., Collingridge, G. L, 1992. Activation of glutamate metabotropic receptors induce long-term potentiation. Eur. J. Pharmacol. 214, 297-298.
4. Breakwell, N.A., Rowan, M.J., Anwyl, R., 1996. Metabotropic glutamate receptor-dependent EPSP and EPSP-spike potentiation in area CA1 of the submerged rat hippocampal slice. J. Neurophysiol. 76, 3126-3135.
5. Brown, R.E., Reymann, K.G., 1995. Metabotropic glutamate receptor agonists reduce paired pulse depression in the dentate gyrus of the rat in vitro. Neurosci. Lett. 196, 17-20.
6. Bushell, T.J., Jane, D.E., Tse, H.-W., Watkins, J.C., Garthwaite, J., Collingridge, G.L., 1996. Pharmacological antagonisms of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br. J. Pharmacol. 117, 1457-1462.
7. Casabona, G., Genazzani, A., Di Stefano, M., Sortino, M.A., Nicoletti, F., 1992. Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices. J. Neurochem. 59, 1161-1163.
8. Chinestra, P., Aniksztejn, L., Diabira, D., Ben-Ari, Y., 1994. (R,S)-α-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons. J. Neurophysiol. 70, 2684-2689.
9. Hölscher, C., Anwyl, R., Rowan, M.J., 1997. Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo. Eur. J. Pharmacol. 322, 155-163.
10. Huang, L., Rowan, M.J., Anwyl, R., 1997. mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD induction, in the dentate gyrus in vitro. Neuroreport 8, 687-693.
11. Ishida, M., Saitoh, T., Shimamoto, K., Ohfune, Y., Shinozaki, H., 1993. A novel metabotropic glutamate receptor agonist: Marked depression of monosynaptic excitation in the newborn rat isolated spinal cord. Brit. J. Pharmacol. 109, 1169-1177.
12. Jane, D.E., Jones, P.L., Pook, P.C.-K., Tse, H.-W., Watkins, J.C., 1994. Actions of two new antagonists showing selectivity for different subtypes of metabotropic glutamate receptor in the neonatal rat spinal cord. Br. J. Pharmacol. 112, 809-816.
13. Jane, D.E., Pittaway, K., Sunter, D.C., Thomas, N.K., Watkins, J.C., 1995. New phenylglycine derivatives with a potent and selective antagonist activity at presynaptic receptors in neonatal rat spinal cord. Neuropharmacology 34, 851-856.
14. Little, Z., Grover, L.M., Teyler, T.J., 1995. Metabotropic glutamate receptor antagonist, (R,S)-α-methyl-4-carboxyphenylglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus. Neurosci. Lett. 201, 73-76.
15. Lovinger, D.M., McCool, B.M., 1995. Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGluR2 or 3. J. Neurophysiol. 73, 1076-1083.
16. Manzoni, O., Bockaert, J., 1995. Metabotropic glutamate receptors inhibiting excitatory synapses in the CA1 area of rat hippocampus. Eur. J. Neurosci. 7, 2518-2523.
17. Manzoni, O.J., Weisskopf, M.G., Nicoll, R.A., 1994. MCPG antagonizes metabotropic glutamate receptors, but not long-term potentiation in the hippocampus. Eur. J. Neurosci. 6, 1050-1054.
18. McGuinness, N., Anwyl, R., Rowan, M.J., 1991. Trans-ACPD enhances long-term potentiation in the hippocampus. Eur. J. Pharmacol. 197, 231-232.
19. O'Connor, J., Rowan, M.J., Anwyl, R., 1995. Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current-investigations of the involvement of mGlu receptors. J. Neurosci. 15, 2013-2020.
20. Petralia, R.S., Wang, Y.-X., Niedzielski, A.S., Wenthold, R.J., 1996. The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations. Neuroscience 71, 949-976.
21. Pook, P.C., Sunter, D.E., Udvarhelyi, P.M., Watkins, J.C., 1992. Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurons by (1S,3S)- and (1S,3R)-ACPD. Exp. Physiol. 77, 529-532.
22. Richter-Levin, G., Errington, M.L., Maegawa, H., Bliss, T.V.P., 1994. Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning. Neuropharmacology 33, 853-857.
23. Riedel, G., Wetzel, W., Reymann, K.G., 1994. (R,S)-α-methyl-4-carboxyphenylglycine (MCPG) blocks spatial learning in rats and long-term potentiation in the dentate gyrus in vivo. Neurosci. Lett. 167, 141-144.
24. Schoepp, D.D., Johnson, B.G., Monn, J.M., 1992. Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist. J. Neurochem. 58, 1184-1186.
25. Schoepp, D.D., Johnson, B.G., 1993. Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus. Neuropharmacology 32, 1359-1365.
26. Schoepp, D.D., Johnson, B.G., Monn, J.A., 1996. (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylic acid-induced increases in cyclic AMP formation in the neonatal rat hippocampus are mediated by a synergistic interaction between phosphoinositide- and inhibitory cyclic AMP-coupled mGluRs. J. Neurochem. 66, 1981-1985.
27. Selig, D.K., Lee, H.-K., Bear, M.F., Malenka, R.C., 1995. Reexamination of the effects of MCPG on hippocampal LTP, LTD and depotentiation. J. Neurophysiol. 74, 1075-1082.
28. Thomsen, C., Bruno, V., Nicoletti, F., Marinozzi, M., Pellicciari, R., 1996. (2S,1′S,2′S,3′R)-2-(2″-carboxy-3′- phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors. Mol. Pharmacol. 50, 6-9.
29. Ugolini, A., Bordi, F., 1995. Metabotropic glutamate group II receptors are responsible for the depression of synaptic transmission induced by ACPD in the dentate gyrus. Eur. J. Pharmacol. 294, 403-410.
30. Wang, Y., Rowan, M.J., Anwyl, R., 1995. R,S-methyl-4-carboxyphenylglycine inhibits long-term potentiation only following the inhibition of low frequency stimulation in the rat dentate gyrus in vitro. Neurosci. Lett. 197, 207-210.