Myofibroblast persistence in fetal sheep wounds is associated with scar formation

Journal of Pediatric Surgery

Volumn 32, Issue 7, 1997, Pages 1017-1022

  Cass, Darrell L ^b   Sylvester, Karl G ^b   Yang, Edmund Y ^b   Crombleholme, Timothy M ^b   Adzick, N Scott ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b NONE

Author keywords

Fetal wound healing; Myofibroblast; Wound contraction; smooth muscle actin

Indexed keywords

ALPHA ACTIN; CYTOSKELETON PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSKELETON; FEMALE; FETUS; GENE EXPRESSION; GESTATIONAL AGE; IMMUNOHISTOCHEMISTRY; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; SCAR FORMATION; SHEEP; SKIN INJURY; WOUND CONTRACTION; WOUND HEALING;

EID: 0030742780     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(97)90390-0     Document Type: Conference Paper

References (19)

1. Cass DL, Bullard KM, Sylvester KG, et al: Wound size and gestational age modulate scar formation in fetal wound repair. J Pediatr Surg 32:411-415, 1997
2. Adzick NS, Lorenz HP: Cells, matrix, growth factors, and the surgeon: The biology of scarless fetal wound repair. Ann Surg 220:10-18, 1994
3. Longaker MT, Whitby DJ, Adzick NS, et al: Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg 25:63-69, 1996
4. Lorenz HP, Whitby DJ, Longaker MT, et al: Fetal wound healing: The ontogeny of scar formation in the non-human primate. Ann Surg 217:391-396, 1993
5. Gabbiani G, Ryan GB, Majno G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27:549-550, 1971
6. Majno G, Gabbiani G, Hirschel BJ, et al: Contraction of granulation tissue in vitro: Similarity to smooth muscle. Science 173:548-550, 1971
7. Desmoulière A: Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol Int 19:471-476, 1995
8. Zhang K, Rekhter MD, Gordon D, et al: Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis: A combined immunohistochemical and in situ hybridization study. Am J Pathol 145:114-125, 1994
9. Longaker MT, Burd DAR, Gown AM, et al: Midgestational fetal lamb excisional wounds contract in utero. J Pediatr Surg 26:942-948, 1991
10. Estes JM, VandeBerg JS, Adzick NS, et al: Phenotypic and functional features of myofibroblasts in fetal wounds. Differentiation 56:173-181, 1994
11. Harrison MR, Jester JA, Ross NA: Correction of congenital diaphragmatic hernia in utero. I. The model: Intrathoracic balloon produces fatal pulmonary hypoplasia. Surgery 88:174-182, 1980
12. Darby I, Skalli O, Gabbiani G: α-Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 63:21-29, 1990
13. Sempowski GD, Borrello MA, Blieden TM, et al: Fibroblast heterogeneity in the healing wound. Wound Rep Reg 3:120-131, 1995
14. Desmoulière A, Geinoz A, Gabbiani F, et al: Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 122:103-111, 1993
15. Serini G, Gabbiani G: Modulation of α-smooth muscle actin expression in fibroblasts by transforming growth factor-β isoforms: An in vivo and in vitro study. Wound Rep Reg 4:278-287, 1996
16. Welch MP, Odland GF, Clark RAF: Temporal relationships of f-actin bundle formation, collagen and fibronectin matrix assembley, and fibronectin receptor expression to wound contraction. J Cell Biol 110:133-145, 1990
17. Desmoulière A, Rubbia-Brandt L, Abdiu A, et al: Heparin induces α-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts. Lab Invest 67:716-726, 1992
18. Desmoulière A, Redard M, Darby I, et al: Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 146:56-66, 1995
19. Shah M, Foreman DM, Ferguson MWJ: Neutralization of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring. J Cell Science 108:985-1002, 1995