PAG-microinjected dipyrone (metamizol) inhibits responses of spinal dorsal horn neurons to natural noxious stimulation in rats

Brain Research

Volumn 759, Issue 1, 1997, Pages 171-174

  Vanegas, Horacio ^a   Tortorici, Víctor ^a   Eblen Zajjur, Antonio ^a,b   Vásquez, Enrique ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b UNIVERSIDAD DE CARABOBO   (Venezuela)

Author keywords

Analgesia; Descending inhibition; Dipyrone; Dorsal horn; NSAID; PAG; Sensory neuron

Indexed keywords

BARBITURIC ACID DERIVATIVE; DIPYRONE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ELECTROPHYSIOLOGY; MALE; NERVE CONDUCTION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SENSORY NERVE CELL; SPINAL CORD DORSAL HORN;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CONSTRICTION; DIPYRONE; EFFERENT PATHWAYS; LUMBOSACRAL REGION; MALE; MICROINJECTIONS; NEURAL INHIBITION; NEURONS, AFFERENT; PAIN; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0030742581     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00360-0     Document Type: Article

References (18)

1. Carlsson K.H., Helmreich J., Jurna I. Activation of inhibition from the periaqueductal gray matter mediates central analgesic effect of metamizol (dipyrone). Pain. 27:1986;373-390.
2. Carlsson K.H., Monzel W., Jurna I. Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate and paracetamol, of activity in rat thalamus neurons evoked by electrical stimulation of nociceptive afferents. Pain. 32:1988;313-326.
3. Cheng Z.F., Fields H.L., Heinricher M.M. Morphine microinjected into the periaqueductal gray has differential effects on 3 classes of medullary neurons. Brain Res. 375:1986;57-65.
4. Dubner R., Kenshalo D.R., Maixner W., Bushnell M.C., Oliveras J.-L. The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli. J. Neurophysiol. 62:1989;450-457.
5. Ferreira S.H., Lorenzetti B.B., Correa F.M.A. Central and peripheral analgesic action of aspirin like drugs. Eur. J. Pharmacol. 53:1978;39-48.
6. Fields H.L., Heinricher M.M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14:1991;219-245.
7. Fields H.L., Malick A., Burstein R. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J. Neurophysiol. 74:1995;1742-1759.
8. Groppetti A., Braga P.C., Biella G., Parenti M., Rusconi L., Mantegazza P. Effect of aspirin on serotonin and Met-enkephalin in brain: Correlation with the antinociceptive activity of the drug. Neuropharmacology. 27:1988;499-505.
9. Maixner W., Dubner R., Bushnell C.M., Kenshalo D.R., Oliveras J.-L. Wide-dynamic-range dorsal horn neurons participate in the encoding process by which monkeys perceive the intensity of noxious heat stimuli. Brain Res. 374:1986;385-388.
10. L.J. Pellegrino, A.S. Pellegrino and A.J. Cushman, A Stereotaxic Atlas of the Rat Brain, 2nd edn., Plenum, New York, 1979.
11. Salganicoff M., Sarna M., Sax L., Gerstein G.L. Unsupervised waveform classification of multineuron recordings: A real-time, software-based system. I. Algorithms and implementation. J. Neurosci. Methods. 25:1988;181-187.
12. Shyu K.W., Lin M.T., Wu T.C. Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey. Exp. Neurol. 84:1984;179-187.
13. Taiwo Y.O., Levine J.D. Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J. Neurosci. 8:1988;1346-1349.
14. Tortorici V., Vanegas H. Putative role of medullary off- and on-cells in the antinociception produced by dipyrone (metamizol) administered systemically or microinjected into PAG. Pain. 57:1994;197-205.
15. Tortorici V., Vanegas H. Anti-nociception induced by systemic or PAG-microinjected lysine-acetylsalicylate in rats. Effects on tail-flick related activity of medullary off- and on-cells. Eur. J. Neurosci. 7:1995;1857-1865.
16. Tortorici V., Vásquez E., Vanegas H. Naloxone partial reversal of the antinociception produced by dipyrone microinjected into the periaqueductal gray of rats. Possible involvement of medullary off- and on-cells. Brain Res. 725:1996;106-110.
17. Vanegas H., Barbaro N.M., Fields H.L. Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons. Brain Res. 321:1984;127-133.
18. Vanegas H., Barbaro N.M., Fields H.L. Tail-flick related activity in medullospinal neurons. Brain Res. 321:1984;135-141.