메뉴 건너뛰기




Volumn 22, Issue 5, 1997, Pages 502-507

Sepinostat Mesilate

Author keywords

[No Author keywords available]

Indexed keywords

SEPINOSTAT; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0030742426     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1997.022.05.408602     Document Type: Review
Times cited : (1)

References (35)
  • 1
    • 0027462090 scopus 로고
    • Synthesis and structure-activity study of protease inhibitors. V. Chemical modification of 6-amidino-2-naphthyl 4-guanidinobenzoate
    • Nakayama, T., Taira, S., Ikeda, M., Ashizawa, H., Oda, M., Arakawa, K., Fujii, S. Synthesis and structure-activity study of protease inhibitors. V. Chemical modification of 6-amidino-2-naphthyl 4-guanidinobenzoate. Chem Pharm Bull 1993, 41: 117-25.
    • (1993) Chem Pharm Bull , vol.41 , pp. 117-125
    • Nakayama, T.1    Taira, S.2    Ikeda, M.3    Ashizawa, H.4    Oda, M.5    Arakawa, K.6    Fujii, S.7
  • 3
    • 0025060855 scopus 로고
    • Pharmacological studies on 6-amidino-2-naphthyl[4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo
    • Oda, M., Ino, Y., Nakamura, K., Kuramoto, S., Shimamura, K., Iwaki, M., Fujii, S. Pharmacological studies on 6-amidino-2-naphthyl[4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo. Jpn J Pharmacol 1990, 52: 23-34.
    • (1990) Jpn J Pharmacol , vol.52 , pp. 23-34
    • Oda, M.1    Ino, Y.2    Nakamura, K.3    Kuramoto, S.4    Shimamura, K.5    Iwaki, M.6    Fujii, S.7
  • 5
    • 0025605493 scopus 로고
    • Pharmacological studies of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate. Effects on experimental pancreatitis
    • Murakami, H., Togawa, M., Takahashi, S., Kasahara, N., Yamamoto, J., Matsuura, N., Koshiyama, Y., Ino, Y., Oda, M. Pharmacological studies of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate. Effects on experimental pancreatitis. Arzneim-Forsch-Drug Res 1990, 40: 1352-8.
    • (1990) Arzneim-Forsch-Drug Res , vol.40 , pp. 1352-1358
    • Murakami, H.1    Togawa, M.2    Takahashi, S.3    Kasahara, N.4    Yamamoto, J.5    Matsuura, N.6    Koshiyama, Y.7    Ino, Y.8    Oda, M.9
  • 7
    • 0029808653 scopus 로고    scopus 로고
    • Synthetic protease inhibitor prevents impaired hepatic secretion of lysosomal enzymes into bile and hepatic lysosomal fragility induced by endotoxin in rats
    • Hirano, T. Synthetic protease inhibitor prevents impaired hepatic secretion of lysosomal enzymes into bile and hepatic lysosomal fragility induced by endotoxin in rats. Dig Surg 1996, 13: 478-83.
    • (1996) Dig Surg , vol.13 , pp. 478-483
    • Hirano, T.1
  • 8
    • 0029968454 scopus 로고    scopus 로고
    • Pancreatic injuries in rats with fecal peritonitis: Protective effect of a new synthetic protease inhibitor, sepinostat mesilate (FUT-187)
    • Hirano, T. Pancreatic injuries in rats with fecal peritonitis: Protective effect of a new synthetic protease inhibitor, sepinostat mesilate (FUT-187). J Surg Res 1996, 61: 301-6.
    • (1996) J Surg Res , vol.61 , pp. 301-306
    • Hirano, T.1
  • 9
    • 0026016052 scopus 로고
    • General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (1). Effects on central and peripheral nervous systems
    • Oda, M., Kojima, T., Koshiyama, Y. et al. General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (1). Effects on central and peripheral nervous systems. Pharmacometrics 1991, 41: 1-11.
    • (1991) Pharmacometrics , vol.41 , pp. 1-11
    • Oda, M.1    Kojima, T.2    Koshiyama, Y.3
  • 10
    • 0026027256 scopus 로고
    • General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (2). Effects on respiratory and cardiovascular systems, isolated smooth muscles and others
    • Kojima, T., Ino, Y., Koshiyama, Y. et al. General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (2). Effects on respiratory and cardiovascular systems, isolated smooth muscles and others. Pharmacokinetics 1991, 41: 13-24.
    • (1991) Pharmacokinetics , vol.41 , pp. 13-24
    • Kojima, T.1    Ino, Y.2    Koshiyama, Y.3
  • 11
    • 1842295471 scopus 로고
    • Reverse mutation test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) with bacteria
    • Kawasaki, K., Terasoma, M., Seki, H., Yokomoto, Y., Ohuchida, A. Reverse mutation test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) with bacteria. Clin Rep 1994, 28(3): 9-17.
    • (1994) Clin Rep , vol.28 , Issue.3 , pp. 9-17
    • Kawasaki, K.1    Terasoma, M.2    Seki, H.3    Yokomoto, Y.4    Ohuchida, A.5
  • 12
    • 1842298488 scopus 로고
    • Chromosomal aberration test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in CHL cells
    • Matsumura, H., Matsumoto, K., Ohta, T., Yokomoto, Y., Ohuchida, A. Chromosomal aberration test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in CHL cells. Clin Rep 1994, 28(3): 19-24.
    • (1994) Clin Rep , vol.28 , Issue.3 , pp. 19-24
    • Matsumura, H.1    Matsumoto, K.2    Ohta, T.3    Yokomoto, Y.4    Ohuchida, A.5
  • 13
    • 1842414005 scopus 로고
    • Micronucleus test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in mice
    • Suzuki, O., Terasoma, M., Seki, H., Yokomoto, Y., Ohuchida, A. Micronucleus test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in mice. Clin Rep 1994, 28(3): 25-8.
    • (1994) Clin Rep , vol.28 , Issue.3 , pp. 25-28
    • Suzuki, O.1    Terasoma, M.2    Seki, H.3    Yokomoto, Y.4    Ohuchida, A.5
  • 14
    • 0027065096 scopus 로고
    • Reproductive and developmental toxicity studies of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (IV) - Oral administration to New Zealand white rabbits during the period of fetal organogenesis
    • Published erratum appears in J Toxicol Sci 1995, 20(1): 76.
    • Shimamura, K., Terabayashi, M., Kuramoto, S., Hasegawa, N., Terazawa, K., Maruden, A. Reproductive and developmental toxicity studies of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (IV) - Oral administration to New Zealand white rabbits during the period of fetal organogenesis. [Published erratum appears in J Toxicol Sci 1995, 20(1): 76]. J Toxicol Sci 1992, 17(Suppl. 4): 253-61.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 253-261
    • Shimamura, K.1    Terabayashi, M.2    Kuramoto, S.3    Hasegawa, N.4    Terazawa, K.5    Maruden, A.6
  • 15
    • 0027080906 scopus 로고
    • Reproductive and developmental toxicity study of 6-amidino-2-naphthyl 4-(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (II) - Oral administration to rats during the period of fetal organogenesis (prenatal examination)
    • Published erratum appears in J Toxicol Sci 1995, 20(1): 76.
    • Shimamura, K., Terazawa, K., Terabayashi, M., Watanabe, K., Hasegawa, N., Kuramoto, S., Yokomoto, Y., Otani, K., Maruden, A. Reproductive and developmental toxicity study of 6-amidino-2-naphthyl 4-(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (II) - Oral administration to rats during the period of fetal organogenesis (prenatal examination). [Published erratum appears in J Toxicol Sci 1995, 20(1): 76]. J Toxicol Sci 1992, 17(Suppl. 4): 221-30.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 221-230
    • Shimamura, K.1    Terazawa, K.2    Terabayashi, M.3    Watanabe, K.4    Hasegawa, N.5    Kuramoto, S.6    Yokomoto, Y.7    Otani, K.8    Maruden, A.9
  • 16
    • 0027080152 scopus 로고
    • Reproductive and developmental toxicity studies of FUT-187. (III) - Postnatal study in rat F1 offspring from dams treated orally with FUT-187 during the period of fetal organogenesis
    • Kawanishi, H., Shiraishi, M., Igarashi, Y., Takeshima, T., Toyohara, S., Imai, S., Shimamura, K., Maruden, A. Reproductive and developmental toxicity studies of FUT-187. (III) - Postnatal study in rat F1 offspring from dams treated orally with FUT-187 during the period of fetal organogenesis. J Toxicol Sci 1992, 17(Suppl. 4): 231-52.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 231-252
    • Kawanishi, H.1    Shiraishi, M.2    Igarashi, Y.3    Takeshima, T.4    Toyohara, S.5    Imai, S.6    Shimamura, K.7    Maruden, A.8
  • 17
    • 0027080153 scopus 로고
    • Reproductive and developmental toxicity studies of FUT-187. (V) - Perinatal and postnatal study in rats with oral administration of FUT-187
    • Furuhashi, T., Uehara, M., Takei, A., Kurihara, H., Yoshida, R., Maruden, A., Shimamura, K. Reproductive and developmental toxicity studies of FUT-187. (V) - Perinatal and postnatal study in rats with oral administration of FUT-187. J Toxicol Sci 1992, 17(Suppl. 4): 263-86.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 263-286
    • Furuhashi, T.1    Uehara, M.2    Takei, A.3    Kurihara, H.4    Yoshida, R.5    Maruden, A.6    Shimamura, K.7
  • 18
    • 0027070901 scopus 로고
    • Reproductive and developmental toxicity studies of FUT-187. (I) - Fertility study in rats with oral administration of FUT-187
    • Furuhashi, T., Uehara, M., Kodama, R., Yoshida, R., Maruden, A., Shimamura, K. Reproductive and developmental toxicity studies of FUT-187. (I) - Fertility study in rats with oral administration of FUT-187. J Toxicol Sci 1992, 17(Suppl. 4): 201-19.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 201-219
    • Furuhashi, T.1    Uehara, M.2    Kodama, R.3    Yoshida, R.4    Maruden, A.5    Shimamura, K.6
  • 19
    • 0027081204 scopus 로고
    • A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs
    • Published errata appear in J Toxicol Sci 1993, 18(4): 276-7 and 1995, 20(1): 74-5.
    • Watanabe, K., Terazawa, K., Terabayashi, M., Kuramoto, S., Yokomoto, Y., Otani, K., Sato, K., Kurotori, M., Shimamura, K., Yamashita, K. A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs. [Published errata appear in J Toxicol Sci 1993, 18(4): 276-7 and 1995, 20(1): 74-5]. J Toxicol Sci 1992, 17(Suppl. 4): 61-99.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 61-99
    • Watanabe, K.1    Terazawa, K.2    Terabayashi, M.3    Kuramoto, S.4    Yokomoto, Y.5    Otani, K.6    Sato, K.7    Kurotori, M.8    Shimamura, K.9    Yamashita, K.10
  • 20
    • 0027050179 scopus 로고
    • A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats
    • Okazaki, S., Todate, A., Yamazaki, E., Anabuki, K., Tamura, K., Hoshiya, T., Maruden, A., Terazawa, K. A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats. J Toxicol Sci 1992, 17(Suppl. 4): 17-59.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 17-59
    • Okazaki, S.1    Todate, A.2    Yamazaki, E.3    Anabuki, K.4    Tamura, K.5    Hoshiya, T.6    Maruden, A.7    Terazawa, K.8
  • 21
    • 0027080151 scopus 로고
    • The evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study
    • Spicer, E.J., Maruden, A., Terazawa, K. The evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study. J Toxicol Sci 1992, 17(Suppl. 4): 101-23.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 101-123
    • Spicer, E.J.1    Maruden, A.2    Terazawa, K.3
  • 22
    • 0027075043 scopus 로고
    • A 52-week chronic oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs
    • Nakano, S., Yada, H., Irimura, K., Asanoma, H., Hirota, T., Terazawa, K. A 52-week chronic oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs. J Toxicol Sci 1992, 17(Suppl. 4): 163-99.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 163-199
    • Nakano, S.1    Yada, H.2    Irimura, K.3    Asanoma, H.4    Hirota, T.5    Terazawa, K.6
  • 23
    • 0027102901 scopus 로고
    • A 52-week oral chronic toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats with a recovery period of 5 weeks
    • Published erratum appears in J Toxicol Sci 1995, 20(1): 75.
    • Okazaki, S., Yamazaki, E., Hatayama, K., Tamura, K., Aikawa, T., Terazawa, K., Maruden, A. A 52-week oral chronic toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats with a recovery period of 5 weeks. [Published erratum appears in J Toxicol Sci 1995, 20(1): 75]. J Toxicol Sci 1992, 17(Suppl. 4): 125-62.
    • (1992) J Toxicol Sci , vol.17 , Issue.4 SUPPL. , pp. 125-162
    • Okazaki, S.1    Yamazaki, E.2    Hatayama, K.3    Tamura, K.4    Aikawa, T.5    Terazawa, K.6    Maruden, A.7
  • 24
    • 1842415169 scopus 로고    scopus 로고
    • Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VI] - Absorption and linearity of sepimostat mesilate and its metabolites after single administration in rats and dogs
    • Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VI] - Absorption and linearity of sepimostat mesilate and its metabolites after single administration in rats and dogs. Clin Rep 1996, 30(10): 9-24.
    • (1996) Clin Rep , vol.30 , Issue.10 , pp. 9-24
    • Kurotori, M.1    Suzuki, M.2    Arakawa, K.3
  • 25
    • 1842298487 scopus 로고    scopus 로고
    • Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VII] - First pass effect of sepimostat mesilate in rats
    • Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VII] - First pass effect of sepimostat mesilate in rats. Clin Rep 1996, 30(10): 25-36.
    • (1996) Clin Rep , vol.30 , Issue.10 , pp. 25-36
    • Kurotori, M.1    Suzuki, M.2    Arakawa, K.3
  • 26
    • 1842377777 scopus 로고    scopus 로고
    • Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VIII] - Tissue distribution after single administration in rats and dogs
    • Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VIII] - Tissue distribution after single administration in rats and dogs. Clin Rep 1996, 30(10): 37-52.
    • (1996) Clin Rep , vol.30 , Issue.10 , pp. 37-52
    • Kurotori, M.1    Suzuki, M.2    Arakawa, K.3
  • 27
    • 1842403917 scopus 로고    scopus 로고
    • Pharmacokinetic studies of sepimostat mesilate (FUT-187) [IX] - Metabolic disposition of sepimostat mesilate and its metabolites after repeated oral administration in rats
    • Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [IX] - Metabolic disposition of sepimostat mesilate and its metabolites after repeated oral administration in rats. Clin Rep 1996, 30(10): 53-68.
    • (1996) Clin Rep , vol.30 , Issue.10 , pp. 53-68
    • Kurotori, M.1    Suzuki, M.2    Arakawa, K.3
  • 28
    • 1842375994 scopus 로고    scopus 로고
    • Pharmacokinetic studies of sepimostat mesilate (FUT-187) after oral administration in healthy volunteers
    • Tei, M., Kodama, K., Yafune, A. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) after oral administration in healthy volunteers. Clin Rep 1996, 30(10): 239-56.
    • (1996) Clin Rep , vol.30 , Issue.10 , pp. 239-256
    • Tei, M.1    Kodama, K.2    Yafune, A.3
  • 29
    • 1842416878 scopus 로고    scopus 로고
    • Pharmacokinetic studies of sepimostat mesilate (FUT-187) [X] - Plasma protein binding of sepimostat mesilate and its metabolites
    • Kurotori, M., Suzuki, M., Arakawa, K., Sato, T., Tsuda, M., Karasawa, Y., Seki, H., Hayashi, K., Takenouchi, N. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [X] - Plasma protein binding of sepimostat mesilate and its metabolites. Clin Rep 1996, 30(10): 69-75.
    • (1996) Clin Rep , vol.30 , Issue.10 , pp. 69-75
    • Kurotori, M.1    Suzuki, M.2    Arakawa, K.3    Sato, T.4    Tsuda, M.5    Karasawa, Y.6    Seki, H.7    Hayashi, K.8    Takenouchi, N.9
  • 30
    • 0026793827 scopus 로고
    • Stability studies on 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in aqueous solution
    • Sasaki, N., Midorikawa, A., Arakawa, K. Stability studies on 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in aqueous solution. Yakugaki Zasshi 1992, 112: 544-50.
    • (1992) Yakugaki Zasshi , vol.112 , pp. 544-550
    • Sasaki, N.1    Midorikawa, A.2    Arakawa, K.3
  • 31
    • 0024229163 scopus 로고
    • High-performance liquid chromatographic determination of 6-amidino-2-naphthyl [4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulphonate and its metabolites in biological fluids
    • Marunaka, T., Maniwa, M., Matsushima, E., Yoshida, K., Azuma, R. High-performance liquid chromatographic determination of 6-amidino-2-naphthyl [4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulphonate and its metabolites in biological fluids. J Chromatogr Biomed Appl 1988, 433: 177-86.
    • (1988) J Chromatogr Biomed Appl , vol.433 , pp. 177-186
    • Marunaka, T.1    Maniwa, M.2    Matsushima, E.3    Yoshida, K.4    Azuma, R.5
  • 32
    • 0028812069 scopus 로고
    • Clinical experience with a novel oral protease inhibitor (FUT-187) in postgastrectomy reflux esophagitis
    • Yoshino, K., Oomori, T. Clinical experience with a novel oral protease inhibitor (FUT-187) in postgastrectomy reflux esophagitis. Jpn Pharmacol Ther 1995, 23(1): 191-7.
    • (1995) Jpn Pharmacol Ther , vol.23 , Issue.1 , pp. 191-197
    • Yoshino, K.1    Oomori, T.2
  • 33
    • 1842331237 scopus 로고    scopus 로고
    • Late phase II study of sepimostat mesilate (FUT-187) in postgastrectomy reflux esophagitis - Clinical optimum dose in a double blind study
    • Abe, O., Yoshino, K., Uchino, J. et al. Late phase II study of sepimostat mesilate (FUT-187) in postgastrectomy reflux esophagitis - Clinical optimum dose in a double blind study. Jpn Pharmacol Ther 1996, 24(4): 143-57.
    • (1996) Jpn Pharmacol Ther , vol.24 , Issue.4 , pp. 143-157
    • Abe, O.1    Yoshino, K.2    Uchino, J.3
  • 34
    • 0028960903 scopus 로고
    • Clinical effects of FUT-187 in reflux esophagitis after gastrectomy
    • Toge, T., Hirai, T., Takiyama, W. et al. Clinical effects of FUT-187 in reflux esophagitis after gastrectomy. Jpn J Cancer Chemother 1995, 22: 539-46.
    • (1995) Jpn J Cancer Chemother , vol.22 , pp. 539-546
    • Toge, T.1    Hirai, T.2    Takiyama, W.3
  • 35
    • 0029026842 scopus 로고
    • Clinical usefulness of FUT-187 (sepimostat mesilate) on reflux esophagitis and gastritis after gastrectomy
    • Makuuchi, H., Kanno, K., Mitomi, T. Clinical usefulness of FUT-187 (sepimostat mesilate) on reflux esophagitis and gastritis after gastrectomy. Jpn J Cancer Chemother 1995, 22: 777-83.
    • (1995) Jpn J Cancer Chemother , vol.22 , pp. 777-783
    • Makuuchi, H.1    Kanno, K.2    Mitomi, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.