-
1
-
-
0027462090
-
Synthesis and structure-activity study of protease inhibitors. V. Chemical modification of 6-amidino-2-naphthyl 4-guanidinobenzoate
-
Nakayama, T., Taira, S., Ikeda, M., Ashizawa, H., Oda, M., Arakawa, K., Fujii, S. Synthesis and structure-activity study of protease inhibitors. V. Chemical modification of 6-amidino-2-naphthyl 4-guanidinobenzoate. Chem Pharm Bull 1993, 41: 117-25.
-
(1993)
Chem Pharm Bull
, vol.41
, pp. 117-125
-
-
Nakayama, T.1
Taira, S.2
Ikeda, M.3
Ashizawa, H.4
Oda, M.5
Arakawa, K.6
Fujii, S.7
-
2
-
-
1842371235
-
-
AU 8545492, EP 190356, ES 8607218, US 4777182, US 4820730, WO 8600893
-
Fujii, S., Okutome, T., Nakayama, T., Nunomura, S., Sudo, K., Watanabe, S., Kurumi, M., Aoyama, T. (Torii & Co., Ltd.). Novel amidine cpds. AU 8545492, EP 190356, ES 8607218, US 4777182, US 4820730, WO 8600893.
-
Novel Amidine Cpds
-
-
Fujii, S.1
Okutome, T.2
Nakayama, T.3
Nunomura, S.4
Sudo, K.5
Watanabe, S.6
Kurumi, M.7
Aoyama, T.8
-
3
-
-
0025060855
-
Pharmacological studies on 6-amidino-2-naphthyl[4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo
-
Oda, M., Ino, Y., Nakamura, K., Kuramoto, S., Shimamura, K., Iwaki, M., Fujii, S. Pharmacological studies on 6-amidino-2-naphthyl[4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo. Jpn J Pharmacol 1990, 52: 23-34.
-
(1990)
Jpn J Pharmacol
, vol.52
, pp. 23-34
-
-
Oda, M.1
Ino, Y.2
Nakamura, K.3
Kuramoto, S.4
Shimamura, K.5
Iwaki, M.6
Fujii, S.7
-
4
-
-
0028917363
-
Inhibitory effects of sepimostat mesilate (FUT-187) on the activities of trypsin-like serine proteases in vitro
-
Nakamura, K., Johmura, A., Oda, M., Ino, Y., Uchiyama, H., Ohtani, H., Miyazaki, H., Kurumi, M., Akizawa, Y., Oka, T. Inhibitory effects of sepimostat mesilate (FUT-187) on the activities of trypsin-like serine proteases in vitro. Yakugaku Zasshi 1995, 115: 201-12.
-
(1995)
Yakugaku Zasshi
, vol.115
, pp. 201-212
-
-
Nakamura, K.1
Johmura, A.2
Oda, M.3
Ino, Y.4
Uchiyama, H.5
Ohtani, H.6
Miyazaki, H.7
Kurumi, M.8
Akizawa, Y.9
Oka, T.10
-
5
-
-
0025605493
-
Pharmacological studies of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate. Effects on experimental pancreatitis
-
Murakami, H., Togawa, M., Takahashi, S., Kasahara, N., Yamamoto, J., Matsuura, N., Koshiyama, Y., Ino, Y., Oda, M. Pharmacological studies of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate. Effects on experimental pancreatitis. Arzneim-Forsch-Drug Res 1990, 40: 1352-8.
-
(1990)
Arzneim-Forsch-Drug Res
, vol.40
, pp. 1352-1358
-
-
Murakami, H.1
Togawa, M.2
Takahashi, S.3
Kasahara, N.4
Yamamoto, J.5
Matsuura, N.6
Koshiyama, Y.7
Ino, Y.8
Oda, M.9
-
6
-
-
0028823534
-
Effects of the oral administration of sepimostat mesilate on cerulein induced acute pancreatitis in rats
-
Wang, Z.H., Manabe, T., Ohshio, G., Hirano, T., Okada, N., Imamura, T., Kawaguchi, Y., Yotsumoto, F., Yamaki, K., Imamura, M. Effects of the oral administration of sepimostat mesilate on cerulein induced acute pancreatitis in rats. Arzneim-Forsch-Drug Res 1995, 45: 1082-6.
-
(1995)
Arzneim-Forsch-Drug Res
, vol.45
, pp. 1082-1086
-
-
Wang, Z.H.1
Manabe, T.2
Ohshio, G.3
Hirano, T.4
Okada, N.5
Imamura, T.6
Kawaguchi, Y.7
Yotsumoto, F.8
Yamaki, K.9
Imamura, M.10
-
7
-
-
0029808653
-
Synthetic protease inhibitor prevents impaired hepatic secretion of lysosomal enzymes into bile and hepatic lysosomal fragility induced by endotoxin in rats
-
Hirano, T. Synthetic protease inhibitor prevents impaired hepatic secretion of lysosomal enzymes into bile and hepatic lysosomal fragility induced by endotoxin in rats. Dig Surg 1996, 13: 478-83.
-
(1996)
Dig Surg
, vol.13
, pp. 478-483
-
-
Hirano, T.1
-
8
-
-
0029968454
-
Pancreatic injuries in rats with fecal peritonitis: Protective effect of a new synthetic protease inhibitor, sepinostat mesilate (FUT-187)
-
Hirano, T. Pancreatic injuries in rats with fecal peritonitis: Protective effect of a new synthetic protease inhibitor, sepinostat mesilate (FUT-187). J Surg Res 1996, 61: 301-6.
-
(1996)
J Surg Res
, vol.61
, pp. 301-306
-
-
Hirano, T.1
-
9
-
-
0026016052
-
General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (1). Effects on central and peripheral nervous systems
-
Oda, M., Kojima, T., Koshiyama, Y. et al. General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (1). Effects on central and peripheral nervous systems. Pharmacometrics 1991, 41: 1-11.
-
(1991)
Pharmacometrics
, vol.41
, pp. 1-11
-
-
Oda, M.1
Kojima, T.2
Koshiyama, Y.3
-
10
-
-
0026027256
-
General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (2). Effects on respiratory and cardiovascular systems, isolated smooth muscles and others
-
Kojima, T., Ino, Y., Koshiyama, Y. et al. General pharmacology of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) (2). Effects on respiratory and cardiovascular systems, isolated smooth muscles and others. Pharmacokinetics 1991, 41: 13-24.
-
(1991)
Pharmacokinetics
, vol.41
, pp. 13-24
-
-
Kojima, T.1
Ino, Y.2
Koshiyama, Y.3
-
11
-
-
1842295471
-
Reverse mutation test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) with bacteria
-
Kawasaki, K., Terasoma, M., Seki, H., Yokomoto, Y., Ohuchida, A. Reverse mutation test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) with bacteria. Clin Rep 1994, 28(3): 9-17.
-
(1994)
Clin Rep
, vol.28
, Issue.3
, pp. 9-17
-
-
Kawasaki, K.1
Terasoma, M.2
Seki, H.3
Yokomoto, Y.4
Ohuchida, A.5
-
12
-
-
1842298488
-
Chromosomal aberration test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in CHL cells
-
Matsumura, H., Matsumoto, K., Ohta, T., Yokomoto, Y., Ohuchida, A. Chromosomal aberration test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in CHL cells. Clin Rep 1994, 28(3): 19-24.
-
(1994)
Clin Rep
, vol.28
, Issue.3
, pp. 19-24
-
-
Matsumura, H.1
Matsumoto, K.2
Ohta, T.3
Yokomoto, Y.4
Ohuchida, A.5
-
13
-
-
1842414005
-
Micronucleus test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in mice
-
Suzuki, O., Terasoma, M., Seki, H., Yokomoto, Y., Ohuchida, A. Micronucleus test of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in mice. Clin Rep 1994, 28(3): 25-8.
-
(1994)
Clin Rep
, vol.28
, Issue.3
, pp. 25-28
-
-
Suzuki, O.1
Terasoma, M.2
Seki, H.3
Yokomoto, Y.4
Ohuchida, A.5
-
14
-
-
0027065096
-
Reproductive and developmental toxicity studies of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (IV) - Oral administration to New Zealand white rabbits during the period of fetal organogenesis
-
Published erratum appears in J Toxicol Sci 1995, 20(1): 76.
-
Shimamura, K., Terabayashi, M., Kuramoto, S., Hasegawa, N., Terazawa, K., Maruden, A. Reproductive and developmental toxicity studies of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (IV) - Oral administration to New Zealand white rabbits during the period of fetal organogenesis. [Published erratum appears in J Toxicol Sci 1995, 20(1): 76]. J Toxicol Sci 1992, 17(Suppl. 4): 253-61.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 253-261
-
-
Shimamura, K.1
Terabayashi, M.2
Kuramoto, S.3
Hasegawa, N.4
Terazawa, K.5
Maruden, A.6
-
15
-
-
0027080906
-
Reproductive and developmental toxicity study of 6-amidino-2-naphthyl 4-(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (II) - Oral administration to rats during the period of fetal organogenesis (prenatal examination)
-
Published erratum appears in J Toxicol Sci 1995, 20(1): 76.
-
Shimamura, K., Terazawa, K., Terabayashi, M., Watanabe, K., Hasegawa, N., Kuramoto, S., Yokomoto, Y., Otani, K., Maruden, A. Reproductive and developmental toxicity study of 6-amidino-2-naphthyl 4-(-)[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187). (II) - Oral administration to rats during the period of fetal organogenesis (prenatal examination). [Published erratum appears in J Toxicol Sci 1995, 20(1): 76]. J Toxicol Sci 1992, 17(Suppl. 4): 221-30.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 221-230
-
-
Shimamura, K.1
Terazawa, K.2
Terabayashi, M.3
Watanabe, K.4
Hasegawa, N.5
Kuramoto, S.6
Yokomoto, Y.7
Otani, K.8
Maruden, A.9
-
16
-
-
0027080152
-
Reproductive and developmental toxicity studies of FUT-187. (III) - Postnatal study in rat F1 offspring from dams treated orally with FUT-187 during the period of fetal organogenesis
-
Kawanishi, H., Shiraishi, M., Igarashi, Y., Takeshima, T., Toyohara, S., Imai, S., Shimamura, K., Maruden, A. Reproductive and developmental toxicity studies of FUT-187. (III) - Postnatal study in rat F1 offspring from dams treated orally with FUT-187 during the period of fetal organogenesis. J Toxicol Sci 1992, 17(Suppl. 4): 231-52.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 231-252
-
-
Kawanishi, H.1
Shiraishi, M.2
Igarashi, Y.3
Takeshima, T.4
Toyohara, S.5
Imai, S.6
Shimamura, K.7
Maruden, A.8
-
17
-
-
0027080153
-
Reproductive and developmental toxicity studies of FUT-187. (V) - Perinatal and postnatal study in rats with oral administration of FUT-187
-
Furuhashi, T., Uehara, M., Takei, A., Kurihara, H., Yoshida, R., Maruden, A., Shimamura, K. Reproductive and developmental toxicity studies of FUT-187. (V) - Perinatal and postnatal study in rats with oral administration of FUT-187. J Toxicol Sci 1992, 17(Suppl. 4): 263-86.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 263-286
-
-
Furuhashi, T.1
Uehara, M.2
Takei, A.3
Kurihara, H.4
Yoshida, R.5
Maruden, A.6
Shimamura, K.7
-
18
-
-
0027070901
-
Reproductive and developmental toxicity studies of FUT-187. (I) - Fertility study in rats with oral administration of FUT-187
-
Furuhashi, T., Uehara, M., Kodama, R., Yoshida, R., Maruden, A., Shimamura, K. Reproductive and developmental toxicity studies of FUT-187. (I) - Fertility study in rats with oral administration of FUT-187. J Toxicol Sci 1992, 17(Suppl. 4): 201-19.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 201-219
-
-
Furuhashi, T.1
Uehara, M.2
Kodama, R.3
Yoshida, R.4
Maruden, A.5
Shimamura, K.6
-
19
-
-
0027081204
-
A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs
-
Published errata appear in J Toxicol Sci 1993, 18(4): 276-7 and 1995, 20(1): 74-5.
-
Watanabe, K., Terazawa, K., Terabayashi, M., Kuramoto, S., Yokomoto, Y., Otani, K., Sato, K., Kurotori, M., Shimamura, K., Yamashita, K. A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs. [Published errata appear in J Toxicol Sci 1993, 18(4): 276-7 and 1995, 20(1): 74-5]. J Toxicol Sci 1992, 17(Suppl. 4): 61-99.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 61-99
-
-
Watanabe, K.1
Terazawa, K.2
Terabayashi, M.3
Kuramoto, S.4
Yokomoto, Y.5
Otani, K.6
Sato, K.7
Kurotori, M.8
Shimamura, K.9
Yamashita, K.10
-
20
-
-
0027050179
-
A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats
-
Okazaki, S., Todate, A., Yamazaki, E., Anabuki, K., Tamura, K., Hoshiya, T., Maruden, A., Terazawa, K. A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats. J Toxicol Sci 1992, 17(Suppl. 4): 17-59.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 17-59
-
-
Okazaki, S.1
Todate, A.2
Yamazaki, E.3
Anabuki, K.4
Tamura, K.5
Hoshiya, T.6
Maruden, A.7
Terazawa, K.8
-
21
-
-
0027080151
-
The evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study
-
Spicer, E.J., Maruden, A., Terazawa, K. The evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study. J Toxicol Sci 1992, 17(Suppl. 4): 101-23.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 101-123
-
-
Spicer, E.J.1
Maruden, A.2
Terazawa, K.3
-
22
-
-
0027075043
-
A 52-week chronic oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs
-
Nakano, S., Yada, H., Irimura, K., Asanoma, H., Hirota, T., Terazawa, K. A 52-week chronic oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in dogs. J Toxicol Sci 1992, 17(Suppl. 4): 163-99.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 163-199
-
-
Nakano, S.1
Yada, H.2
Irimura, K.3
Asanoma, H.4
Hirota, T.5
Terazawa, K.6
-
23
-
-
0027102901
-
A 52-week oral chronic toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats with a recovery period of 5 weeks
-
Published erratum appears in J Toxicol Sci 1995, 20(1): 75.
-
Okazaki, S., Yamazaki, E., Hatayama, K., Tamura, K., Aikawa, T., Terazawa, K., Maruden, A. A 52-week oral chronic toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in rats with a recovery period of 5 weeks. [Published erratum appears in J Toxicol Sci 1995, 20(1): 75]. J Toxicol Sci 1992, 17(Suppl. 4): 125-62.
-
(1992)
J Toxicol Sci
, vol.17
, Issue.4 SUPPL.
, pp. 125-162
-
-
Okazaki, S.1
Yamazaki, E.2
Hatayama, K.3
Tamura, K.4
Aikawa, T.5
Terazawa, K.6
Maruden, A.7
-
24
-
-
1842415169
-
Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VI] - Absorption and linearity of sepimostat mesilate and its metabolites after single administration in rats and dogs
-
Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VI] - Absorption and linearity of sepimostat mesilate and its metabolites after single administration in rats and dogs. Clin Rep 1996, 30(10): 9-24.
-
(1996)
Clin Rep
, vol.30
, Issue.10
, pp. 9-24
-
-
Kurotori, M.1
Suzuki, M.2
Arakawa, K.3
-
25
-
-
1842298487
-
Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VII] - First pass effect of sepimostat mesilate in rats
-
Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VII] - First pass effect of sepimostat mesilate in rats. Clin Rep 1996, 30(10): 25-36.
-
(1996)
Clin Rep
, vol.30
, Issue.10
, pp. 25-36
-
-
Kurotori, M.1
Suzuki, M.2
Arakawa, K.3
-
26
-
-
1842377777
-
Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VIII] - Tissue distribution after single administration in rats and dogs
-
Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [VIII] - Tissue distribution after single administration in rats and dogs. Clin Rep 1996, 30(10): 37-52.
-
(1996)
Clin Rep
, vol.30
, Issue.10
, pp. 37-52
-
-
Kurotori, M.1
Suzuki, M.2
Arakawa, K.3
-
27
-
-
1842403917
-
Pharmacokinetic studies of sepimostat mesilate (FUT-187) [IX] - Metabolic disposition of sepimostat mesilate and its metabolites after repeated oral administration in rats
-
Kurotori, M., Suzuki, M., Arakawa, K. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [IX] - Metabolic disposition of sepimostat mesilate and its metabolites after repeated oral administration in rats. Clin Rep 1996, 30(10): 53-68.
-
(1996)
Clin Rep
, vol.30
, Issue.10
, pp. 53-68
-
-
Kurotori, M.1
Suzuki, M.2
Arakawa, K.3
-
28
-
-
1842375994
-
Pharmacokinetic studies of sepimostat mesilate (FUT-187) after oral administration in healthy volunteers
-
Tei, M., Kodama, K., Yafune, A. et al. Pharmacokinetic studies of sepimostat mesilate (FUT-187) after oral administration in healthy volunteers. Clin Rep 1996, 30(10): 239-56.
-
(1996)
Clin Rep
, vol.30
, Issue.10
, pp. 239-256
-
-
Tei, M.1
Kodama, K.2
Yafune, A.3
-
29
-
-
1842416878
-
Pharmacokinetic studies of sepimostat mesilate (FUT-187) [X] - Plasma protein binding of sepimostat mesilate and its metabolites
-
Kurotori, M., Suzuki, M., Arakawa, K., Sato, T., Tsuda, M., Karasawa, Y., Seki, H., Hayashi, K., Takenouchi, N. Pharmacokinetic studies of sepimostat mesilate (FUT-187) [X] - Plasma protein binding of sepimostat mesilate and its metabolites. Clin Rep 1996, 30(10): 69-75.
-
(1996)
Clin Rep
, vol.30
, Issue.10
, pp. 69-75
-
-
Kurotori, M.1
Suzuki, M.2
Arakawa, K.3
Sato, T.4
Tsuda, M.5
Karasawa, Y.6
Seki, H.7
Hayashi, K.8
Takenouchi, N.9
-
30
-
-
0026793827
-
Stability studies on 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in aqueous solution
-
Sasaki, N., Midorikawa, A., Arakawa, K. Stability studies on 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187) in aqueous solution. Yakugaki Zasshi 1992, 112: 544-50.
-
(1992)
Yakugaki Zasshi
, vol.112
, pp. 544-550
-
-
Sasaki, N.1
Midorikawa, A.2
Arakawa, K.3
-
31
-
-
0024229163
-
High-performance liquid chromatographic determination of 6-amidino-2-naphthyl [4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulphonate and its metabolites in biological fluids
-
Marunaka, T., Maniwa, M., Matsushima, E., Yoshida, K., Azuma, R. High-performance liquid chromatographic determination of 6-amidino-2-naphthyl [4-(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulphonate and its metabolites in biological fluids. J Chromatogr Biomed Appl 1988, 433: 177-86.
-
(1988)
J Chromatogr Biomed Appl
, vol.433
, pp. 177-186
-
-
Marunaka, T.1
Maniwa, M.2
Matsushima, E.3
Yoshida, K.4
Azuma, R.5
-
32
-
-
0028812069
-
Clinical experience with a novel oral protease inhibitor (FUT-187) in postgastrectomy reflux esophagitis
-
Yoshino, K., Oomori, T. Clinical experience with a novel oral protease inhibitor (FUT-187) in postgastrectomy reflux esophagitis. Jpn Pharmacol Ther 1995, 23(1): 191-7.
-
(1995)
Jpn Pharmacol Ther
, vol.23
, Issue.1
, pp. 191-197
-
-
Yoshino, K.1
Oomori, T.2
-
33
-
-
1842331237
-
Late phase II study of sepimostat mesilate (FUT-187) in postgastrectomy reflux esophagitis - Clinical optimum dose in a double blind study
-
Abe, O., Yoshino, K., Uchino, J. et al. Late phase II study of sepimostat mesilate (FUT-187) in postgastrectomy reflux esophagitis - Clinical optimum dose in a double blind study. Jpn Pharmacol Ther 1996, 24(4): 143-57.
-
(1996)
Jpn Pharmacol Ther
, vol.24
, Issue.4
, pp. 143-157
-
-
Abe, O.1
Yoshino, K.2
Uchino, J.3
-
34
-
-
0028960903
-
Clinical effects of FUT-187 in reflux esophagitis after gastrectomy
-
Toge, T., Hirai, T., Takiyama, W. et al. Clinical effects of FUT-187 in reflux esophagitis after gastrectomy. Jpn J Cancer Chemother 1995, 22: 539-46.
-
(1995)
Jpn J Cancer Chemother
, vol.22
, pp. 539-546
-
-
Toge, T.1
Hirai, T.2
Takiyama, W.3
-
35
-
-
0029026842
-
Clinical usefulness of FUT-187 (sepimostat mesilate) on reflux esophagitis and gastritis after gastrectomy
-
Makuuchi, H., Kanno, K., Mitomi, T. Clinical usefulness of FUT-187 (sepimostat mesilate) on reflux esophagitis and gastritis after gastrectomy. Jpn J Cancer Chemother 1995, 22: 777-83.
-
(1995)
Jpn J Cancer Chemother
, vol.22
, pp. 777-783
-
-
Makuuchi, H.1
Kanno, K.2
Mitomi, T.3
|