Synthesis of N-desmethyl PNQX: Elaboration into an immunogenic conjugate and a radioiodinated ligand; radioimmunoassay for the AMPA/NMDA antagonist, PNQX

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 15, 1997, Pages 1979-1984

  Bigge, Christopher F ^a   Yi, C Stephen ^a   Nordblom, Gerald D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,7,8,9,10 HEXAHYDRO 9 METHYL 6 NITROPYRIDO[3,4 F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR ANTAGONIST; IODINE 125; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; THYROGLOBULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MASS SPECTROMETRY; MICRODIALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RABBIT; RADIOIMMUNOASSAY; TECHNIQUE;

EID: 0030742384     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00344-2     Document Type: Article

References (6)

1. Bigge, C. F.; Malone, T. C.; Boxer, P. A.; Nelson, C. B.; Ortwine, D. F.; Schelkun, R. M.; Retz., D. M.; Lescosky, L. J.; Borosky, S. A.; Vartanian, M. G.; Schwarz, R. D.; Campbell, G. W.; Robichaud, L. J.; Wätjen, F. J. Med. Chem. 1995, 38, 3720.
2. Sheardown, M. J.; Nielsen, E. O.; Hansen, A. J.; Jacobsen, P.; Honore, T. Science 1990, 247, 571.
3. Welty, D. F.; Cochrane, L. L.; Borosky, S. A.; Vartanian, M. G.; Schielke, G. P.; Boxer, P. A.; Bigge, C. F. Pharmaceutical Research 1995, 12 (PPDM 8291), S399.
4. Schielke, G. P.; Kupina, N. C.; Boxer, P. A.; Cordon, J. J.; Bigge, C. F.; Marcoux, F. W. J. Cereb. Blood Flow Metab. 1995, 15 (Suppl 1), S372.
5. 50 = 890 nM), which probably reflects steric limitations in the region of the N-9 tether.
6. 125I]-product at 68 min.