Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas: Implications for prostate cancer biology

American Journal of Pathology

Volumn 151, Issue 2, 1997, Pages 471-478

  Soler, Alejandro Peralta ^a,d   Harner, Gary D ^a   Knudsen, Karen A ^a   McBrearty, Francis X ^a   Grujic, Edina ^a   Salazar, Hernando ^b   Han, Aaron C ^b   Keshgegian, Albert A ^c  

^a LANKENAU HOSPITAL   (United States)

^b READING HOSPITAL AND MEDICAL CENTER   (United States)

^c BRYN MAWR HOSPITAL   (United States)

^d LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CADHERIN P; NERVE CELL ADHESION MOLECULE; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG; UVOMORULIN;

ACCESSORY SEX ORGAN; ARTICLE; ATROPHY; CLINICAL ARTICLE; CONTROLLED STUDY; EJACULATORY DUCT; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE EPITHELIUM; PROSTATECTOMY; PROTEIN EXPRESSION; SEMINAL VESICLE;

ANIMALS; CADHERINS; CARCINOMA; EPITHELIUM; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; PROSTATE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0030742124     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Ozawa M, Baribault H, Kemler R: The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 1989, 8:1711-1717
2. Gumbiner B, Simons K: A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like peptide. J Cell Biol 1986, 102:457-468
3. Hatta K, Takeichi M: Expression of N-cadherin adhesion molecules associated with early morphogenic events in chick development. Nature 1986, 320:447-449
4. Hatta K, Takagi S, Fujisawa H, Takeichi M: Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenic processes of chicken embryos, Dev Biol 1987, 120:215-227
5. Nose A, Takeichi M: A novel cadherin adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol 1986, 103:2649-2658
6. Hirai Y, Nose A, Kobayashi S, Takeichi M: Expression and role of E-and P-cadherin adhesion molecules in embryonic histogenesis. I, Lung epithelial morphogenesis. Development 1989, 105:263-270
7. Hirai Y, Nose A, Kobayashi S, Takeichi M: Expression and role of E-and P-cadherin adhesion molecules in embryonic histogenesis. II. Skin morphogenesis. Development 1989, 105:271-277
8. Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O: Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 1989, 49:2128-2133
9. Daniel CW, Strickland P, Friedman Y: Expression and functional role of E- and P-cadherins in mouse mammary ductal morphogenesis and growth. Dev Biol 1995, 169:511-519
10. Hodivala KJ, Watt FM: Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J Cell Biol 1994, 124:589-600
11. Takeichi M: The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 1988, 102:639-655
12. Steinberg MS, Takeichi M: Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. Proc Natl Acad Sci USA 1994, 91:206-209
13. Hedrick L, Cho KR, Vogelstein B: Cell adhesion molecules as tumour suppressors. Trends Cell Biol 1993, 3:36-39
14. Behrens J, Mareel MM, Van Roy FM, Birchmeier W: Dissecting tumor cell invasion: epithelial cells acquire invasive properties after loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989, 108:2435-2447
15. Peralta Soler A, Knudsen KA, Tecson-Miguel A, McBrearty FX, Han AC, Salazar H: The expression of E-cadherin and N-cadherin in surface epithelial-stromal tumors of the ovary distinguishes mucinous from serous and endometriold tumors. Hum Pathol 1997, 28:734-739
16. Peralta Soler A, Knudsen KA, Jaurand M-C, Johnson KR, Wheelock MJ, Klein-Szanto AJP, Salazar H: The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas, Hum Pathol 1995, 26:1363-1369
17. Boring CC, Squires TS, Tong T: Cancer statistics, 1993. CA Cancer J Clin 1993, 43:7-26
18. McNeal JE, Leav I, Alroy J, Skutelsky E: Differential lectin staining of central and peripheral zones of the prostate and alterations in dysplasia, Am J Clin Pathol 1988, 89:41-48
19. McNeal JE: Prostate. Histology for Pathologists. Edited by SS Sternberg, New York, Raven Press, 1992, pp 749-763
20. Wang MC, Valenzuela LA, Murphy GP, Chu TM: Purification of a human prostatic specific antigen. Invest Urol 1979, 17:159-163
21. Wang MC, Papsidero LD, Kuriyama M, Valenzuela LA, Murphy GP, Chu TM: Prostate antigen: a new potential marker for prostatic cancer. Prostate 1981, 2:89-96
22. Sesterhenn I, Mostofi FK, Davis CJ Jr: Immunopathology of prostate and bladder tumors, Immunocytochemistry in Tumor Diagnosis, Edited by J Russo. Boston, Martinus Nijhoff Publishing, 1985, pp 337-361
23. Wolf DA, Schulz P, Fittler F: Transcriptional regulation of prostate kallikrein-like genes by androgen. Mol Endocrinol 1992, 6:753-762
24. Umbas R, Schalken JA, Aalders TW, Carter BS, Karthaus HFM, Schaafsma HE, Debruyne FMJ, Isaacs WB: Expression of the cellular molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res 1992, 52:5104-5109
25. Morton RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB: Reduction of E-cadherin levels and deletion of the α-catenin gene in human prostate cancer cells. Cancer Res 1993, 53:3585-3590
26. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HFM, Oosterhof GON, Debruyne FMJ, Schalken JA: Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 1994, 54:3929-3933
27. Graft JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB: E-cadherin expression is silenced by DNA methylation in human breast and prostate carcinomas. Cancer Res 1995, 55:5195-5199
28. Han AC, Peralta Soler A, Knudsen KA, Wheelock MJ, Johnson KR, Salazar H: Differential expression of N-cadherin in pleural mesotheliomas and E-cadherin in lung adenocarcinomas in formalin-fixed, paraffin-embedded tissues. Hum Pathol 1997, 28:641-645
29. Gumbiner BM: Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996, 84:345-357
30. Blaschuk OW, Munro SB, Farookhi R: Cadherins, steroids, and cancer, Endocrine 1995, 3:83-89
31. Ringwald M, Baribault H, Schmidt C, Kemler R: The structure of the gene coding for the mouse cell adhesion molecule uvomorulin. Nucleic Acids Res 1991, 19:6533-6539
32. Riegman PHJ, Vliestra RJ, van der Korput JAGM, Brinkmann AO, Trapman J: The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 1991, 5:1921-1930
33. Chung LWK, Davies R: Prostate epithelial differentiation is dictated by its surrounding stroma. Mol Biol Rep 1996, 23:13-19
34. Zhau HYE, Chang S-M, Chen B-Q, Wang Y, Zhang H, Kao C, Sang QA, Pathak SJ, Chung LWK: Androgen-repressed phenotype in human prostate cancer. Proc Natl Acad Sci USA 1996, 93:15152-15157
35. Nakhla AM, Rosner W: Stimulation of prostate cancer growth by androgens and estrogens through the intermediancy of sex hormone-binding globulin, Endocrinology 1996, 137:4126-4129
36. Nazareth LV, Weigel NL: Activation of the human androgen receptor through a protein kinase A signalling pathway, J Biol Chem 1996, 271:19900-19907
37. Nakhla AM, Romas NA, Rosner W: Estradiol activates the prostate androgen receptor and prostate-specific antigen secretion through the intermediancy of sex hormone-binding globulin. J Biol Chem 1997, 272:6838-6841
38. Johnson KR, Lewis JE, Li D, Wahl J, Peralta Soler A, Knudsen KA, Wheelock MJ: P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207:252-260
39. Shimoyama Y, Hirohashi S: Expression of E- and P-cadherin in gastric carcinomas. Cancer Res 1991, 51:2185-2192
40. Soares P, Berx G, van Roy F, Sobrinho-Simoes M: E-cadherin gene alterations are rare events in thyroid tumors. Int J Cancer 1997, 70:32-38
41. Hedrick L, Epstein JI: Use of keratin 903 as an adjunct in the diagnosis of prostate carcinoma. Am J Surg Pathol 1989, 13:389-396
42. Miniati ON, Chang Y, Shu W-P, Peehl DM, Liu BC-S: Role of prostatic basal cells in the regulation and suppression of human prostate cancer cells. Cancer Lett 1996, 104:137-144
43. Catalona WJ, Ritchie JP, Ahman FR, Hudson MA, Scardino PT, Flanigan RC, deKernion JB, Ratliff TL, Kavoussi LR, Dalkin BL, Waters WB, MacFarlane MT, Southwick PC: Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol 1994, 151:1283-1290
44. Mai KT, Commons S, Perkins G, Yazdi HM, Collins JP: Absence of serum prostate-specific antigen and loss of tissue immunoreactive prostatic markers in advanced prostatic adenocarcinoma after hormonal therapy: a report of two cases. Hum Pathol 1996, 27:1377-1381
45. Mahan DE, Bruce AW, Manley PN, Franchi L: Immunohistochemical evaluation of prostatic carcinoma before and after radiotherapy. J Urol 1980, 124:488-491
46. Crook JM, Bahadur YA, Robertson SJ, Perry GA, Esche BA: Evaluation of radiation effect, tumor differentiation, and prostate specific antigen staining in sequential prostate biopsies after external beam radiotherapy for patients with prostate carcinoma. Cancer 1997, 79: 81-89
47. Katayama M, Hirai S, Kamihagi K, Nakagawa K, Yasumoto M, Kato I: Soluble E-cadherin fragments increased in circulation of cancer patients. Br J Cancer 1994, 69:580-585
48. Griffths TRL, Brotherick I, Bishop RI, White MD, McKenna DM, Home CHW, Shenton BK, Neal DE, Mellon JK; Cell adhesion molecules in bladder cancer: soluble serum E-cadherin correlates with predictors of recurrence. Br J Cancer 1996, 74:579-584