A nonlethal, anesthetized canine model for efficacy evaluation of anticyanide therapy

International Journal of Toxicology

Volumn 16, Issue 2, 1997, Pages 141-149

  Reid, F M ^a   Menton, R G ^a   Audet, K K ^a   Marino, M ^b   Brewer, T G ^b   Korte, D W ^c  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c Department of Pharmaceutical Sciences   (United States)

Author keywords

Animal model; Anticyanide therapy; Cyanide; Methemoglobin; Nonlethal anesthetized animal model; Sodium cyanide

Indexed keywords

HYDROXYLAMINE; METHEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYANIDE POISONING; DOG; DOSE RESPONSE; DRUG EFFECT; NONHUMAN; RESPIRATORY ARREST;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030742116     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158197227233     Document Type: Article

References (10)

1. Ballantyne, B., and Marrs, T. C., eds. 1987. Clinical and experimental toxicology of cyanides. Bristol, UK: Wright.
2. Bright, J. E., and Marrs, T. C. 1987. Effect of p-aminopropiophenone (PAPP), a cyanide antidote, on cyanide given by intravenous infusion. Human Toxicol. 6:33.
3. Fraser, C. M., ed. 1986. Part III, clinical values and procedures. The Merck veterinary manual, 6th ed. Rathway, NJ: Merck.
4. Groff, W. A., Stemler, F. W., Kaminskis, A., Froehlich, H. L., and Johnson, R. P. 1985. Plasma free cyanide and blood total cyanide: a rapid completely automated microdistillation assay. Clin. Toxicol. 23:133-163.
5. Jandorf, B. J., and Bodansky, O. 1946. Therapeutic and prophylactic effect of methemoglobinemia in inhalation poisoning by hydrogen cyanide and cyanogen chloride. J. Ind. Hyg. Toxicol. 28:125.
6. Kiese, M., and Weger, N. 1969. Formation of ferrihemoglobin with aminophenols in the human for the treatment of cyanide poisoning. Eur. J. Pharmacol. 7:91.
7. Menton, R. G., Reid, F. M., Olson, C. T., Niemuth, N. A., Audet, K. K., Marino, M., Brewer, T. G., and Korte, D. W. In press. Comparative efficacy of three methemoglobin formers in delaying effects of infused sodium cyanide. J. Am. Coll. Toxicol.
8. Vick, J. A., and Froehlich, H. 1991. Treatment of cyanide poisoning. Mil. Med. 156:330-339.
9. von Bredow, J., Vick, J. A., Brewer, T., and Kaminskis, A. 1992. Animal models for the estimation of cyanide toxicity and evaluation of effectiveness of pre-treatments and antidotes. The Pharmacologist 34:174.
10. von Bredow, J., Vick, J. A., Kaminskis, A., and Brewer, T. 1993. A non-lethal, repeated testing, anesthetized canine model for the evaluation of effectiveness of new forms of prophylaxis and therapy for cyanide intoxication. Proc. 1993 Med. Defense Biosci. Rev. 2:861-868.