Natural killer cell receptors

Current Opinion in Immunology

Volumn 9, Issue 3, 1997, Pages 344-350

  Long, Eric O ^a   Wagtmann, Nicolai ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

HEMATOPOIETIC CELL; NATURAL KILLER CELL; REVIEW;

EID: 0030741601     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80080-5     Document Type: Article

References (69)

1. Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. of special interest Immunity. 5:1996;537-549 Mice deficient in the Ikaros transcription factor lack B cells, NK cells, and a subset of T cells.
2. Scott P, Trinchieri G. The role of natural killer cells in host-parasite interactions. Curr Opin Immunol. 7:1995;34-40.
3. Moretta A, Bottino C, Vitale M, Pende D, Biassoni R, Mingari MC, Moretta L. Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol. 14:1996;619-648.
4. Raulet DH. Recognition events that inhibit and activate natural killer cells. Curr Opin Immunol. 8:1996;372-377.
5. Lanier LL. NK cell receptors and MHC class I interactions. Curr Opin Immunol. 9:1997;126-132.
6. Held W, Cado D, Raulet DH. Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. of special interest J Exp Med. 184:1996;2037-2041 Formal proof by transgene expression that Ly49A confers specific recognition of MHC class I and mediates inhibition of NK cells.
7. d and mediates inhibition of NK cells. Defective Ly49A-mediated inhibition in NK cells of motheaten mice suggests that SHP-1 is involved in Ly49-mediated inhibition.
8. Yu YYL, George T, Dorfman JR, Roland J, Kumar V, Bennett M. The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. of special interest Immunity. 4:1996;67-76 Demonstration that Ly49 receptors provide specificity in hybrid resistance.
9. + NK cells are responsible for mediating the rejection of H-2b bone marrow allografts in mice. Int Immunol. 8:1996;1833-1839.
10. Brennan J, Mahon G, Mager DL, Jefferies WA, Takei F. Recognition of class I major histocompatibility complex molecules by Ly-49: Specificities and domain interactions. of special interest J Exp Med. 183:1996;1553-1559 MHC class I specificity is determined by sequences in both the CRD and the stem region of the Ly49A and Ly49C receptor.
11. Brennan J, Lemieux S, Freeman JD, Mager DL, Takei F. Heterogeneity among Ly49C natural killer (NK) cells: characterization of highly related receptors with differing functions and expression patterns. J Exp Med. 184:1996;2085-2090.
12. Wagtmann N, Rajagopalan S, Winter CC, Peruzzi M, Long EO. Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. Immunity. 3:1995;801-809.
13. Dohring C, Scheidegger D, Samaridis J, Cella M, Colonna M. A human killer inhibitory receptor specific for HLA-A. of special interest J Immunol. 156:1996;3098-3101 See annotation [14].
14. Pende D, Biassoni R, Cantoni C, Verdiani S, Falco M, Di Donato C, Accame L, Bottino C, Moretta A, Moretta L. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. of special interest J Exp Med. 184:1996;505-518 This paper, along with [13], describes a KIR with three Ig domains which is specific for HLA-A3 and related allotypes.
15. Parham P. NK cells, MHC class I antigens and missing self. Immunol Rev. 155:1997;5-221.
16. Rojo S, Burshtyn DN, Long EO, Wagtmann N. Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. of special interest J Immunol. 158:1997;9-12 See annotation [17].
17. Wang LL, Mehta IK, LeBlanc PA, Yokoyama WM. Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors. of special interest J Immunol. 158:1997;13-17 This paper, along with [16], describes an inhibitory receptor belonging to the Ig superfamily which is expressed in mouse mast cells and NK cells.
18. Phillips JH, Chang CW, Mattson J, Gumperz JE, Parham P, Lanier LL. CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. of outstanding interest Immunity. 5:1996;163-172 Demonstration that human CD94 forms disulfide-linked heterodimers with a variable tyrosine phosphorylated protein. CD94, a type II transmembrane C-type lectin, is involved in the recognition of multiple HLA-A, -B and -C allotypes.
19. Katz HR, Vivier E, Castells MC, McCormick MJ, Chambers JM, Austen KF. Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE. Proc Natl Acad Sci USA. 93:1996;10809-10814.
20. Sivori S, Vitale M, Bottino C, Marcenaro E, Sanseverino L, Parolini S, Moretta L, Moretta A. CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. of special interest Eur J Immunol. 26:1996;2487-2492 Evidence for CD94 heterogeneity and for CD94 involvement in the recognition of multiple HLA class I allotypes.
21. Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. of special interest J Immunol. 157:1996;4741-4745 See annotation [23].
22. Brooks AG, Posch PE, Scorzelli CJ, Borrego F, Coligan JE. NKG2A complexed with CD94 defines a novel inhibitory NK cell receptor. of special interest J Exp Med. 185:1997;795-800 See annotation [23].
23. Carretero M, Cantoni C, Bellon T, Bottino C, Biassoni R, Rodriguez A, Perez-Villar JJ, Moretta L, Moretta A, Lopez-Botet M. The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules. of special interest Eur J Immunol. 27:1997;563-567 This paper, along with [21,22], describes that CD94 and NKG2 isoforms are expressed as disulfide-linked heterodimers, forming a repertoire of clonally distributed NK receptor complexes.
24. Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. of special interest J Immunol. 158:1997;3603-3609 Isoforms of NKG2 with different cytoplasmic tails can either inhibit or activate NK cells.
25. Mingari MC, Vitale C, Cambiaggi A, Schiavetti F, Melioli G, Ferrini S, Poggi A. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: Expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int Immunol. 7:1995;697-703.
26. Phillips JH, Gumperz JE, Parham P, Lanier LL. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class 1 receptors on T lymphocytes. Science. 268:1995;403-405.
27. D'Andrea A, Chang C, Phillips JH, Lanier LL. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J Exp Med. 184:1996;789-794.
28. Held W, Dorfman JR, Wu MF, Raulet DH. Major histocompatibility complex class I-dependent skewing of the natural killer cell Ly49 receptor repertoire. of special interest Eur J Immunol. 26:1996;2286-2292 Self-MHC class I molecules influence the repertoire of Ly49-expressing NK cells. Interesting discussion of models to explain self-tolerance by NK cells and the MHC-controlled repertoire of Ly49 receptors.
29. Sundbäck J, Kärre K, Sentman CL. Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly49C, differentially controlled by host genes in the MHC and NK gene complexes. J Immunol. 157:1996;3936-3942.
30. Gosselin P, Lusignan Y, Brennan J, Takei F, Lemieux S. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by host major histocompatibility class I alleles. Int Immunol. 1997;. in press.
31. Gumperz JE, Valiante NM, Parham P, Lanier LL, Tyan D. Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibility complex haplotype. of special interest J Exp Med. 183:1996;1817-1827 The frequency of NK cells expressing a KIR specific for HLA-Bw4 and the surface expression level of such a KIR are under genetic control, yet appear to be unlinked to HLA haplotypes.
32. Dohring C, Colonna M. Human natural killer cell inhibitory receptors bind to HLA class I molecules. Eur J Immunol. 26:1996;365-369.
33. Fan QR, Garboczi DN, Winter CC, Wagtmann N, Long EO, Wiley DC. Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule. of special interest Proc Natl Acad Sci USA. 93:1996;7178-7183 Soluble KIR and soluble HLA-C form 1:1 complexes in the absence of carbohydrate modification.
34. Biassoni R, Falco M, Cambiaggi A, Costa P, Verdiani S, Pende D, Conte R, Di Donato C, Parham P, Moretta L. Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by group 2 or group 1 NK clones. J Exp Med. 182:1995;605-609.
35. Mandelboim O, Reyburn HT, Valés-Gómez M, Pazmany L, Colonna M, Borsellino G, Strominger JL. Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules. J Exp Med. 184:1996;913-922.
36. Malnati MS, Peruzzi M, Parker KC, Biddison WE, Ciccone E, Moretta A, Long EO. Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science. 267:1995;1016-1018.
37. Peruzzi M, Parker KC, Long EO, Malnati MS. Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. of special interest J Immunol. 157:1996;3350-3356 See annotation [38].
38. Peruzzi M, Wagtmann N, Long EO. A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705. of special interest J Exp Med. 184:1996;1585-1590 This paper, along with [37], describes a single HLA-Bw4-specific KIR which can discriminate among HLA-B*2705 molecules containing nonamer peptides with different amino acids at positions seven and eight.
39. Gumperz JE, Litwin V, Phillips JH, Lanier LL, Parham P. The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp Med. 181:1995;1133-1144.
40. Falk CS, Steinle A, Schendel DJ. Expression of HLA-C molecules confers target cell resistance to some non-major histocompatibility complex-restricted T cells in a manner analogous to allospecific natural killer cells. J Exp Med. 182:1995;1005-1018.
41. Pazmany L, Mandelboim O, Vales-Gomez M, Davis DM, Reyburn HT, Strominger JL. Protection from natural killer cell-mediated lysis by HLA-G expression on target cells. Science. 274:1996;792-795.
42. Munz C, Holmes N, King A, Loke YW, Colonna M, Schild H, Rammensee HG. HLA-G molecules inhibit NKAT3 expressing natural killer cells. J Exp Med. 185:1997;385-391.
43. Perez-Villar JJ, Melero I, Navarro F, Carretero M, Bellon T, Llano M, Colonna M, Geraghty D, Lopez-Botet M. The CD94/NKG2-A inhibitory receptor complex is involved in NK cell-mediated recognition of cells expressing HLA-G1. J Immunol. 1997;. in press.
44. Correa I, Raulet DH. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity. 2:1995;61-71.
45. Orihuela M, Margulies DH, Yokoyama WM. The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. Proc Natl Acad Sci USA. 93:1996;11792-11797.
46. Apte RS, Niederkorn JY. Isolation and characterization of a unique natural killer cell inhibitory factor present in the anterior chamber of the eye. of special interest J Immunol. 156:1996;2667-2673 The anterior chamber of the eye, an immune privileged site, contains a soluble protein that can inhibit NK- but not T-cell-mediated cytotoxicity.
47. Kaufman DS, Schoon RA, Robertson MJ, Leibson PJ. Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I. Proc Natl Acad Sci USA. 92:1995;6484-6488.
48. Valiante NM, Phillips JH, Lanier LL, Parham P. Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/PLC-gamma signaling complex in human natural killer (NK) cells. of special interest J Exp Med. 184:1996;2243-2250 Binding of KIRs to MHC class I molecules on target cells prevents the formation of complexes between PLC-γ and the adaptor protein pp36.
49. Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet JP, Long EO. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. of special interest Immunity. 4:1996;77-85 Functional evidence that the tyrosine phosphitase SHP-1 is involved in the inhibitory signal delivered by KIR.
50. Olcase L, Lang P, Vély F, Cambiaggi A, Marguet D, Bléry M, Hippen KL, Biassoni R, Moretta A, Moretto L, et al. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTPID protein tyrosine phosphatases. of special interest J Immunol. 156:1996;4531-4534 Biochemical studies showing that tyrosine phosphorylated peptides from both KIR and Ly49 bind the tyrosine phosphatases SHP-1 and SHP-2.
51. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ. Sequential involvement of Ick and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. of special interest Immunity. 5:1996;629-638 The tyrosine kinase Ick can phosphorylate KIR, and the engagement of KIR on NK cells reduces the CD16-induced tyrosine phosphorylation of ζ ZAP-70 and PLC-γ.
52. Brumbaugh KM, Perez-Villar JJ, Dick CJ, Schoon RA, Lopez-Botet M, Leibson PJ. Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses. J Immunol. 157:1996;2804-2812.
53. Biassoni R, Cantoni C, Falco M, Verdiani S, Bottino C, Vitale M, Conte R, Poggi A, Moretta A, Moretta L. The human leukocyte antigen (HLA)-C-specific activatory or inhibitory natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. of special interest J Exp Med. 183:1996;645-650 Expression of KIR-related molecules with short cytoplasmic tails in NK clones correlates with activation rather than inhibition of the NK cells upon recognition of HLA-C allotypes.
54. Bottino C, Sivori S, Vitale M, Cantoni C, Falco R, Pende D, Morelli L, Augugliaro R, Semenzato G, Biassoni R, et al. A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. of special interest Eur J Immunol. 26:1996;1816-1824 See annotation [55].
55. Mandelboim O, Davis DM, Reyburn HT, Vales-Gomez M, Sheu EG, Pazmany L, Strominger JL. Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins. of special interest Science. 274:1996;2097-2100 This paper, along with [54], provides further evidence that KIR-related molecules with short cytoplasmic tails may activate NK and T cells.
56. Mason LH, Anderson SK, Yokoyama WM, Smith HRC, Winkler-Pickett R, Ortaldo JR. The Ly-49D receptor activates murine NK cells. of special interest J Exp Med. 184:1996;2119-2128 Ly49D, a molecule lacking an ITIM motif, can activate mouse NK cells after antibody-mediated cross-linking.
57. Dissen E, Ryan JC, Seaman WE, Fossum S. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. of special interest J Exp Med. 183:1996;2197-2207 Identification in the rat of a NK gene complex encoding several Ly49-related isoforms with different cytoplasmic tails.
58. Naper C, Rolstad B, Wonigeit K, Butcher GW, Vaage JT. Genes in two MHC class I regions control recognition of a single rat NK cell allodeterminant. of special interest Int Immunol. 8:1996;1779-1785 Rat NK cells may be stimulated by nonclassical class I molecules and inhibited by classical class I molecules.
59. Kraus E, Lambracht D, Wonigeit K, Hunig T. Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition. of special interest Eur J Immunol. 26:1996;2582-2586 A target cell transfected with rat MHC class I genes and a rat NK cell line were used to show that both classical and nonclassical MHC class I gene products can inhibit rat NK cells.
60. Castells MC, Wu X, Arm JP, Austen KF, Katz HR. Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J Biol Chem. 269:1994;8393-8401.
61. Puzanov IJ, Bennett M, Kumar V. IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells. of special interest J Immunol. 157:1996;4282-4285 IL-15 can induce differentiation of immature NK cells into functional effector cells.
62. Lanier LL, Corliss B, Phillips JH. Arousal and inhibition of human NK cells. Immunol Rev. 155:1997;145-154.
63. + T cells upon NKR-P1 cross-linking. J Exp Med. 183:1996;2391-2396.
64. Miyazaki T, Dierich A, Benoist C, Mathis D. Independent modes of natural killing distinguished in mice lacking Lag3. of special interest Science. 272:1996;405-408 LAG-3-deficient mice reveal a function for LAG-3 in activation of NK cytotoxicity against certain tumor targets.
65. Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, Phillips JH. DNAM-1, a novel adhesion molecule involved in the cytolytic functions of T lymphocytes. of special interest Immunity. 4:1996;573-581 DNAM-1, a novel molecule with Ig domains, is required to activate NK lysis of certain (but not all) tumor target cells.
66. Chambers BJ, Salcedo M, Ljunggren HG. Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1). of special interest Immunity. 5:1996;311-317 CD80 (B7-1) on target cells can activate killing by mouse NK cells.
67. Litwin V, Gumperz J, Parham P, Phillips JH, Lanier LL. Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type. J Exp Med. 178:1993;1321-1336.
68. Helander TS, Carpen O, Turunen O, Kovanen PE, Vaheri A, Timonen T. ICAM-2 redistributed by ezrin as a target for killer cells. of outstanding interest Nature. 382:1996;265-268 Evidence that ezrin-induced redistribution of ICAM-2 into uropods renders cells sensitive to lysis by NK cells.
69. Tsukita S, Yonemura S. ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction. Curr Opin Cell Biol. 9:1997;70-75.