Metabolic cobalamin deficiency in patients with low to low-normal plasma cobalamins

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 57, Issue 3, 1997, Pages 209-215

  Moelby, L ^a   Nielsen, G ^a   Rasmussen, K ^b   Jensen, M K ^a   Pedersen, K O ^a  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Methylmalonic acid; Neuropsychiatric disorders; Vitamin B12 deficiency

Indexed keywords

COBALAMIN; METHYLMALONIC ACID;

ADULT; AGED; ANALYTIC METHOD; ANEMIA; ARTICLE; CLINICAL ARTICLE; COMPETITIVE INHIBITION; CYANOCOBALAMIN DEFICIENCY; DIAGNOSTIC TEST; DRUG BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; KIDNEY FUNCTION; MALE; MENTAL DISEASE; METABOLIC DISORDER; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0030741058     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365519709060029     Document Type: Article

References (28)

1. Rasmussen K, Pedersen KO, Mortensen ES, Mølby L, Jensen MK. Laboratoriediagnostik af cobalaminmangel. Ugeskr Læger 1992; 154: 326-30.
2. Lindenbaum J, Healton EB, Savage DG, Brust JCM, Garret TJ, Podell ER, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988; 318: 1720-8.
3. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Cobalamin deficiency and neuropsychiatric disorders (letter). N Engl J Med 1988; 319: 1734.
4. Herbert V. Cobalamin deficiency and neuropsychiatric disorders (letter). N Engl J Med 1988; 319: 1733.
5. Norman EJ, Denton MD, Martekko OJ, Flessa HC. Cobalamin deficiency and neuropsychiatric disorders (letter). N Engl J Med 1988; 319: 1733.
6. Gimsing P, Nexø E. Cobalamin-binding capacity of haptocorrin and transcobalamin: age-correlated reference intervals and values from patients. Clin Chem 1989; 35: 1447-51.
7. Herbert V. Don't ignore low serum cobalamin (vitamin B12) levels (editorial). Arch Intern Med 1988; 148: 1705-7.
8. Nexø E, Hansen M, Rasmussen K, Lindgren A, Gräsbeck R. How to diagnose cobalamin deficiency. Scand J Clin Lab Invest 1994, 54 Suppl 219: 61-76.
9. Gräsbeck R. Measurement of serum cobalamin. In: Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, editors. Advances in Thomas Addison's diseases. Vol. 2, Norwich: Page Bros, 1994: 313-20.
10. Nexø E. Cobalamin assays. In: Guéant JL, Nicolas JP, editors. Cobalamin and related binding proteins in clinical nutrition. 1990: 80-94.
11. Nexø E. Variation with age of reference values for P-cobalamin. Scand J Haematol 1983; 30: 430-2.
12. Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60: 2-11.
13. Joosten E, Pelemans W, Devos P, Lesaffre E, Criel A, Verhaeghe R. Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin. Eur J Haematol 1993; 51: 25-30.
14. Joosten E, van den Berg A, Reizler R, Naurath HJ, Lindenbaum J, Stabler S, et al. Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 1993; 58: 468-76.
15. Carmel R. Pernicious anemia, the expected findings of very low serum cobalamin levels, anemia and macrocytosis are often lacking. Arch Intern Med 1988; 148: 1712-4.
16. Moelby L, Rasmussen K, Jensen MK, Pedersen KO. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid. J Intern Med 1990; 228: 373-8.
17. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990; 76: 871-81.
18. Marcell PD, Stabler SP, Podell ER, Allen RH. Quantitation of methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1985; 150: 58-66.
19. Rasmussen K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989; 35: 260-4.
20. Rasmussen K, Møller J, Østergaard K, Kristensen MØ, Jensen J. Methylmalonic acid concentrations in serum of normal subjects: biological variability and effect of oral L-isoleucine loads before and after intramuscular administration of cobalamin. Clin Chem 1990; 36: 1295-9.
21. Rasmussen K, Vyberg B, Pedersen KO, Brøchner-Mortensen J. Methylmalonic acid in renal insufficiency. Evidence of accumulation and implications for diagnosis of cobalamin deficiency (letter). Clin Chem 1990; 36: 1523-4.
22. Moelby L, Rasmussen K, Rasmussen HH. Serum methylmalonic acid in uraemia. Scand J Clin Lab Invest 1992; 52: 351-4.
23. Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994; 96: 239-46.
24. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency II: Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990; 34: 99-107.
25. Rasmussen K, Moelby L, Jensen MK. Studies on methylmalonic acid in humans. II Relationship between concentrations in serum and urinary excretion, and the correlation between serum cobalamin and accumulation of methylmalonic acid. Clin Chem 1989; 35: 2277-80.
26. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Diagnosis of cobalamin deficiency. I Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990; 34: 90-8.
27. Altman DG, Gardener MJ. In: Gardener MJ, Altman DG, editors. Statistics with confidence. London: Br Med J 1989: 40-1.
28. Rasmussen K, Møller J, Lyngbak M, Pedersen AMH, Dybkjær L. Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem 1996; 42: 630-6.