Effect of the glutamine synthetase inhibitor, methionine sulfoximine, on the growth and differentiation of Dictyostelium discoideum

FEMS Microbiology Letters

Volumn 151, Issue 2, 1997, Pages 163-168

  Dunbar, Andrew J ^a   Wheldrake, John F ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Ammonia assimilation; Dictyostelium discoideum; Glutamine synthetase; Methionine sulfoximine

Indexed keywords

GLUTAMATE AMMONIA LIGASE; METHIONINE SULFOXIMINE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL DIFFERENTIATION; DICTYOSTELIUM DISCOIDEUM; DRUG EFFECT; ENZYME INHIBITION; GROWTH INHIBITION; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL;

AMMONIA; ANIMALS; DICTYOSTELIUM; GLUTAMATE-AMMONIA LIGASE; METHIONINE SULFOXIMINE;

DICTYOSTELIUM DISCOIDEUM;

EID: 0030741022     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00154-7     Document Type: Article

References (20)

1. Gregg, J.H., Hackney, A.L. and Krivanek, J.O. (1954) Nitrogen metabolism of the slime mould Dictyostelium discoideum during growth and morphogenesis. Biol. Bull. 107, 226-235.
2. Schindler, J. and Sussman, M. (1977) Ammonia determines the choice of morphogenetic pathways in Dictyostelium discoideum. J. Mol. Biol. 116, 161-170.
3. Wilson, J.B. and Rutherford, C.L. (1978) ATP, trehalose, glucose and ammonia ion localisation in the two cell types of Dictyostelium discoideum. J. Cell Physiol. 94, 37-46.
4. Schindler, J. and Sussman, M. (1979) Inhibition by ammonia of intracellular cAMP accumulation in Dictyostelium discoideum: its significance for the regulation of morphogenesis. Dev. Genet. 1, 13-20.
5. Williams, J.B., Elder, E.M. and Sussman, M. (1984) Modulation of the cAMP relay in Dictyostelium discoideum by ammonia and other metabolites: possible morphogenetic consequences. Dev. Biol. 105, 377-388.
6. Davies, L., Satre, M., Martin, J.-B. and Gross, J.D. (1993) The target of ammonia action in Dictyostelium. Cell 75, 321-327.
7. +-ATPase and weak base action in Dictyostelium. Mol. Microbiol. (in press).
8. Moore, D., Horner, J. and Liu, M. (1987) Co-ordinate control of ammonium-scavenging enzymes in the fruit body cap of Coprinus cinereus avoids inhibition of sporulation by ammonium. FEMS Microbiol. Lett. 44, 239-242.
9. Kilonsky, D.J., Herman, P.K. and Emr, S.D. (1990) The fungal vacuole: composition, function, and biogenesis. Microbiol. Rev. 54, 266-292.
10. Wiemken, A. and Durr, M. (1974) Characterisation of amino acid pools in the vacuolar compartment of Saccharomyces cerevisiae. Arch. Microbiol. 101, 45-57.
11. Dunbar, A.J. and Wheldrake, J.F. (1995) Evidence for a developmentally regulated prespore specific glutamine synthetase in the cellular slime mould Dictyostelium discoideum. Microbiology 141, 1125-1130.
12. 13C-NMR study of Dictyostelium discoideum metabolism: monitoring of the spore germination process. Eur. J. Biochem. 193, 135-142.
13. Dunbar, A.J. and Wheldrake, J.F. (1996) Purification and properties of glutamine synthetase in the cellular slime mould Dictyostelium discoideum (submitted).
14. Sussman, M. (1987) Cultivation and synchronous morphogenesis of Dictyostelium under controlled experimental conditions. Methods Cell Biol. 28, 9-29.
15. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
16. Nellen, W., Datta, S., Reymond, C., Sivertsen, A., Mann, S., Crowley, T. and Firtel, R.A. (1987) Molecular biology in Dictyostelium: Tools and applications. Methods Cell Biol. 28, 67-99.
17. Dunbar, A.J. and Wheldrake, J.F. (1996) Northern blot analysis of a developmentally regulated prespore specific glutamine synthetase in Dictyostelium discoideum (submitted).
18. Ronzio, R.A. and Meister, A. (1969) Inhibition of glutamine synthetase by methionine sulphoximine: studies on methionine sulphoximine phosphate. Biochemistry 8, 2674-2680.
19. Pamula, F. and Wheldrake, J.F. (1991) The NAD-dependent glutamate dehydrogenase from Dictyostelium discoideum: Purification and properties. Arch. Biochem. Biophys. 291, 225-230.
20. Pamula, F. and Wheldrake, J.F. (1992) The effect of AMP on the NAD-dependent glutamate dehydrogenase during activation and morphogenesis in the cellular slime moulds. J. Gen. Microbiol. 138, 1935-1940.