In vitro addition of glutathione to blood from zinc-deficient rats corrects platelet defects: Impaired aggregation and calcium uptake

Journal of Nutritional Biochemistry

Volumn 8, Issue 6, 1997, Pages 346-350

  O'Dell, Boyd L ^a,b   Emery, Michelle ^a   Xia, Jinming ^a   Browning, Jimmy D ^a  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

calcium uptake; glutathione; membrane sulfhydryls; platelet aggregation; rat; zinc status

Indexed keywords

CALCIUM; GLUTATHIONE; ZINC;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; RAT; THROMBOCYTE AGGREGATION;

EID: 0030740695     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-2863(97)00020-X     Document Type: Article

References (29)

1. Gordon, P.R. and O'Dell, B.L. (1980). Rat platelet aggregation impaired by short-term zinc deficiency. J. Nutr. 110, 2125-2129
2. Emery, M.P., Browning, J.D., and O'Dell, B.L. (1990). Impaired hemostasis and platelet aggregation in rats fed low zinc diets based on egg white protein. J. Nutr. 120, 1062-1067
3. Xia, J. and O'Dell, B.L. (1995) Zinc deficiency in rats decreases thrombin-stimulated platelet aggregation by lowering protein kinase C activity secondary to impaired calcium uptake. J. Nutr. Biochem. 6, 661-666
4. Emery, M.P. and O'Dell, B.L. (1991). Compromised zinc status in rats adversely affects calcium metabolism in platelets. J. Nutr. 121, 1763-1768
5. Emery, M.P. and O'Dell, B.L. (1993). Low zinc status in rats impairs calcium uptake and aggregation of platelets stimulated by fluoride. Proc. Soc. Exp. Biol. Med. 203, 480-484
6. O'Dell, B.L. (1981). Metabolic functions of zinc - a new look. In: Trace Element Metabolism in Man and Animals, (Howell, J.McC., Gawthorne, J.M., and White, C.L., eds.), p. 319-326, Australian Academy of Science, Canberra, Australia
7. Xia, J. and O'Dell, B.L. (1995). Relationship of plasma membrane sulfhydryl concentration to zinc deficiency pathology. FASEB J. 9, A867
8. Zucker, M.B. and Mauss, E.A. (1986). Modification of platelet functions by monobromobimame, a fluorescent thiol group label. Thromb. Haemostasis 55, 228-234
9. Aledort, L.M., Troup, S.B., and Weed, R.I. (1968). Inhibition of sulfhydryl-dependent platelet functions by penetrating and non-penetrating analogues of parachloromercuribenzene. Blood 31, 471-479
10. Harbury, C.B. and Schrier, S.L. (1974). Modification of platelet sulfhydryl groups. Thrombos. Diathes. Haemorrh. 31, 469-484
11. MacIntyre, D.E., Grainge, C.A., Drummond, A.H. and Gordon, J.L. (1977). Effect of thiol reagents on platelet transport processes and responses to stimuli. Biochem. Pharmacol. 26, 319-323
12. 2+ influx induced by collagen or arachidonate on rabbit platelets. Biochim. Biophys. Acta 928, 266-271
13. Sugatani, J., Steinhelper, M.E., Saito, K., Olson, M.S., and Hanahan, D.J. (1987) Potential involvement of vicinal sulfhydryls in stimulus-induced rabbit platelet activation. J. Biol. Chem. 262, 16995-17000
14. O'Dell, B.L., Browning, J.D., and Reeves, P.G. (1983). Plasma levels of prostaglandin metabolites in zinc-deficient female rats near term. J. Nutr. 113, 760-765
15. Ardlie, N.G. and Han, P. (1974). Enzymatic basis for platelet aggregation and release: the significance of the "platelet atmosphere" and the relationship between platelet function and blood coagulation. Br. J. Haemotol. 26, 331-355
16. Habeeb, A.F.S.A (1972). Reaction of protein sulfhydryls with Ellman's reagent. Methods Enzymol 34, 457-464
17. Lowry, O.R., Rosebrough, N.J., and Randall, R.A. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
18. Marcus, A.J. and Safier, L.B. (1993). Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J. 7, 516-522
19. Valles, J., Santos, M.T., Aznar, J., Marcus, A.J., Martinez-Sales, V., Portoles, M., Broekman, M.J., and Safier, L.B. (1991). Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment. Blood 78, 154-162
20. Fernandez, M.A. and O'Dell, B.L. (1983). Effect of zinc deficiency on plasma glutathione in the rat. Proc. Soc. Exp. Biol. Med. 173, 564-567
21. Mills, B.J., Lindeman, R.D., and Lang, C.A. (1981) Effect of zinc deficiency on blood glutathione levels. J. Nutr. 111, 1098-1102
22. Siess, W. (1989) Molecular mechanisms of platelet activation. Physiol. Rev. 69, 158-178
23. 2+ flux in human platelets. FEBS 180, 160-164
24. Valone, F.H. and Johnson, B. (1987) Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. Biochem. J. 247, 669-674
25. Xia, J., Emery, M., and O'Dell, B.L. (1994). Zinc status and distribution of protein kinase C in rat platelets. J. Nutr. Biochem. 5, 536-541
26. Ono, Y., Fujii, T., Igarashi, K., Kuno, T., Tanaka, C., Kikkawa, U., and Nishiszuka, Y. (1989). Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger sequence. Proc. Natl. Acad. Sci. USA 86, 4868-4871
27. Ahmed, S., Kozma, R., Lee, J., Monfries, C., Harden, N., and Lim, L. (1991). The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Biochem. J. 280, 233-241
28. Browning, J.D. and O'Dell, B.L. (1994). Low zinc status in guinea pigs impairs calcium uptake by brain synaptosomes. J. Nutr. 124, 436-443
29. Browning, J.D. and O'Dell, B.L. (1995). Low zinc status impairs calcium uptake by hippocampal synaptosomes stimulated by potassium but not by n-methyl-D-aspartate. J. Nutr. Biochem. 6, 588-594