Intramural drug delivery by direct injection within the arterial wall: First clinical experience with a novel intracoronary deliver-infiltrator system

Catheterization and Cardiovascular Diagnosis

Volumn 41, Issue 3, 1997, Pages 287-292

  Pavlides, Gregory S ^a   Barath, Peter ^b   Maginas, Athanasios ^a   Vasilikos, Vasilios ^a   Cokkinos, Dennis V ^a   O'Neill, William W ^c  

^a ONASSIS CARDIAC SURGERY CENTER   (Greece)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

Angioplasty; Local delivery; Restenosis; Stents

Indexed keywords

GLYCERYL TRINITRATE; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTERY WALL; ARTICLE; BALLOON CATHETER; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; INTRACORONARY INFUSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; RESTENOSIS; STENT; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME;

ADULT; AGED; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; CORONARY ANGIOGRAPHY; CORONARY DISEASE; CORONARY VESSELS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; FEMALE; FIBRINOLYTIC AGENTS; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; INJECTIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; RECURRENCE; RETREATMENT; STENTS;

EID: 0030740664     PISSN: 00986569     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0304(199707)41:3<287::AID-CCD9>3.0.CO;2-2     Document Type: Article

References (18)

1. Wilensky RL, March KL, Gradus-Pizlo I, Spaedy AJ, Hathaway DR: Methods and devices for local drug delivery in coronary and peripheral arteries. Trends Cardiovasc Med 3:163-170, 1993.
2. Lincoff AM, Topol EJ, Ellis SG: Local drug delivery for the prevention of restenosis. Fact, fancy and future. Circulation 90:2070-2084, 1994.
3. Schwartz RS, Huber KC, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR: Restenosis and the proportional neointimal response to coronary artery injury: Results in a porcine model. J Am Coll Cardiol 19:267-274, 1992.
4. Stadius ML, Collins C, Kernoff R: Local infusion balloon angioplasty to obviate restenosis compared with conventional balloon angioplasty in an experimental model of atherosclerosis. Am Heart J 126:47-56, 1993.
5. Hong MK, Bhatti T, Matthews BJ, Stark KS, Cathapermal SS, Foegh ML, Ramwell PW, Kent KM: The effect of porous infusion balloon delivered angiopeptin on myointimal hyperplasia following balloon injury in the rabbit. Circulation 88:636-648, 1993.
6. Kot PA, Ramwell PW: Inhibition of myointimal proliferation of the rat carotid artery by the peptides angiopeptin and BIM 23034. Atherosclerosis 80:49-55, 1989.
7. Goldman B, Blanke H, Wolinsky H: Influence of pressure on permeability of normal and diseased muscular arteries to horseradish peroxidase. Atherosclerosis 65:215-225, 1987.
8. Wolinsky H, Thung SN: Use of perforated balloon catheter to deliver concentrated heparin into the wall of the normal canine artery. J Am Coll Cardiol 15:475-481, 1990.
9. Lambert CR, Leone JE, Rowland SM: Local drug delivery catheters: Functional comparison of porous and microporous designs. Coron Artery Dis 4:469-475, 1993.
10. Hong MK, Wong SC, Farb A, Mehlman MD, Virmani R, Barry JJ, Leon MB: Feasibility and drug delivery efficiency of a new balloon angioplasty catheter capable of performing simultaneous local drug delivery. Coron Artery Dis 4:1023-1027, 1993.
11. Fram DB, Aretz T, Azrin MA, Mitchel JF, Samady H, Gillam LD, Sahatjan R, Waters D, McKay RG: Localized intramural drug delivery during balloon angioplasty using hydrogel-coated balloons and pressure-augmented diffusion. J Am Coll Cardiol 23:1570-1577, 1994.
12. Araki H, Muramoto J, Nishi K, Jougasaki M, Inoue M: Heparin adheres to the damaged arterial wall and inhibits its thrombogenicity. Circ Res 71:577-584, 1992.
13. Heras M, Chesebro JH, Webster MWI: Hirudin, heparin and placebo during deep arterial injury in the pig: The in vivo role of thrombin in platelet-mediated thrombosis. Circulation 82:1476-1484, 1990.
14. Guyton JR, Rosenberg RD, Clowes AW, Karnovsky MJ: Inhibition of rat arterial smooth muscle cell proliferation by heparin. In vivo studies with anticoagulant and nonanticoagulant heparin. Circ Res 46:625-634, 1980.
15. Gimple LW, Gertz SD, Haber HL, Ragosta M, Powers ER, Roberts WC, Sarembock IJ: Effect of chronic subcutaneous or intramural administration of heparin on femoral artery restenosis after balloon angioplasty in hypercholesterolemic rabbits: Aquantitative angiographic and histopathological study. Circulation 86:1536-1546, 1992.
16. Edelman ER, Adams DH, Karnovsky MJ: Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury. Proc Natl Acad Sci USA 87:3773-3777, 1990.
17. Fischman DL, Leon MB, Baim DS, Schatz RA, Savage MP, Penn I, Detre K, Valtri L, Ricci D, Nobuyoshi M, Cleman M, Heuser R, Almond D, Teirstein PS, Fish RD, Colombo A, Brinker J, Moses J, Shaknovich A, Hirshfeld J, Bailey S, Ellis S, Rake R, Goldberg S: A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 331:496-501, 1994.
18. Serruys PW, de Jaegere P, Kiemeneij F, Macaya C, Rutsch W, Heyndrickx G, Emanuelsson H, Marco J, Legrand V, Materne P, Berlardi J, Sigwart U, Colombo A, Goy JJ, van den Heuvel P, Delcan J, Morel M: A comparison of balloon-expandable stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med 331:489-495, 1994.