Genomic organization of the extracellular coding region of the human fgfr4 and flt4 genes: Evolution of the genes encoding receptor tyrosine kinases with immunoglobulin-like domains

Journal of Molecular Evolution

Volumn 45, Issue 1, 1997, Pages 43-49

  Agnès, François ^a   Toux, Marguerite Marie ^a   André, Catherine ^a   Galibert, Francis ^a  

^a Inst de Rech Contre le Cancer IRCC   (France)

Author keywords

Duplications; Extracellular immunoglobulin like domains; Intron insertion; Receptor tyrosine kinase

Indexed keywords

IMMUNOGLOBULIN; PROTEIN TYROSINE KINASE;

ARTICLE; AUTOPHOSPHORYLATION; DIMERIZATION; EVOLUTION; EXON; EXTRACELLULAR MATRIX; GENE CLUSTER; GENE DUPLICATION; GENETIC CODE; GENETIC ORGANIZATION; HUMAN; HUMAN CELL; INTRON; PROTEIN DOMAIN;

EXONS; EXTRACELLULAR SPACE; GENES; GENES, IMMUNOGLOBULIN; HUMANS; INTRONS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; RECEPTORS, CELL SURFACE; RECEPTORS, FIBROBLAST GROWTH FACTOR; SEQUENCE HOMOLOGY, AMINO ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 0030740229     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00006199     Document Type: Article

References (24)

1. Agnès F, Shamoon B, Dina C, Rosnet O, Birbaum D, Galibert F (1994) Genomic structure of the downstream part of the human FLT3 gene: exon/intron structure conservation among genes encoding receptor tyrosine kinases (RTK) of subclass III. Gene 145:283-288
2. André C, Martin E, Cornu F, Hu W, Wang X, Galibert F (1992) Genomic organization of the human c-kit gene: Evolution of the receptor tyrosine kinase subclass III. Oncogene 7:685-691
3. Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, McMahon J, Wasmuth J, Huebner K, Alitalo K (1992) FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter. Cancer Res 52:746-748
4. Bairoch A, Bucher P, Hofmann K (1996) The prosite database, its status in 1995. Nucleic Acids Res 24:221-222
5. Breathnach R, Chambon P (1981) Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem 50: 349-383
6. Cybulski MI, Fries JWU, Williams AJ, Sultan P, Eddy R, Byers M, Shows T, Gimbrone MAJ, Collins T (1991) Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc Natl Acad Sci USA 88:7859-7863
7. Fantl WJ, Johnson DE, Williams LT (1993) Signaling by receptor tyrosine kinases. Annu Rev Biochem 62:453-481
8. Galland F, Karamysheva A, Mattei M, Rosnet O, Marchetto S, Birbaum D (1992) Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. Genomics 13:475-478
9. Hampe A, Shamoon B, Gobet M, Sherr CJ, Galibert F (1989) Nucleotide sequence and structural organization of the human FMS protooncogene. Oncogene Res 4:9-17
10. Imbert A, Rosnet O, Marchetto S, Ollendorff D, Birnbaum D, Pébusque MJ (1994) Characterization of a yeast artificial chromosome from human band 13q12 containing FLT1 and FLT3 receptor-type tyrosine kinase genes. Cytogenet Cell Genet 67:175-177
11. Johnson DE, Lu J, Chen H, Werner S, Williams LT (1991) The human fibroblast growth factor receptor genes: a common structural rearrangement underlies the mechanisms for generating receptor forms that differ in their immunoglobulin domain. Mol Cell Biol 11: 4627-4634
12. Lawlor DA, Zemmour J, Ennis PD, Parham P (1990) Evolution of class-I MHC genes and proteins: from natural selection to thymic selection. Annu Rev Immunol 8:23-63
13. McLachlan AD (1987) Gene duplication and the origin of repetitive protein structures. Cold Spring Harb Symp Quant Biol 52:411-420
14. O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R, Le-Beau MM, Earp HS, Liu ET (1991) Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol 11:5016-5031
15. Partanen J, Mäkelä TP, Eerola E, Korhonen J, Hirvonen H, ClaessonWelsch L, Alitalo K (1991) FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J 10:1347-1354
16. Roberts WM, Look AT, Roussel MF, Sherr CJ (1988) Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes. Cell 55:655-661
17. Rosnet O, Stephenson D, Mattei M, Marchetto S, Shibuya M. Chapman VM, Birnbaum D (1993) Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and on chromosome 5 in mouse. Oncogene 8:173-179
18. Rousset D, Agnès F, Lachaume P, André C, Galibert F (1995) Molecular evolution of the genes encoding receptor tyrosine kinase with immunoglobulinlike domains. J Mol Evol 41:421-430
19. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
20. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chainterminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
21. Sers C, Kirsch K, Rothbächer U, Riethmüller G, Johnson P (1993) Genomic organization of the melanoma-associated glycoprotein MUC18: implication for the evolution of immunoglobulin domains. Proc Natl Acad Sci USA 90:8514-8518
22. Schlessinger J, Ullrich A (1992) Growth factor signaling by receptor tyrosine kinases. Neuron 9:383-391
23. Spritz RA, Strunk KM, Lee S, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (1994) A YAC contig spanning a cluster of human type III receptor tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome 4q12. Genomics 22:431-436
24. Ullrich A, Schlessinger J (1990) Signal transduction by receptor with tyrosine kinase activity. Cell 61:203-212