Human mast cells expressing recombinant proteinase 3 (PR3) as substrate for clinical testing for anti-neutrophil cytoplasmic antibodies (ANCA)

Clinical and Experimental Immunology

Volumn 109, Issue 2, 1997, Pages 286-295

  Specks, U ^a   Wiegert, E M ^a   Homburger, H A ^a  

^a MAYO CLINIC   (United States)

Author keywords

ANCA; Immunofluoresence; Proteinase 3; Wegener's granulomatosis

Indexed keywords

GRANULOCYTE ANTIBODY; PROTEINASE; RECOMBINANT PROTEIN; SERINE PROTEINASE;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MAST CELL; NEUTROPHIL; PRIORITY JOURNAL; WEGENER GRANULOMATOSIS;

EID: 0030739698     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.4561353.x     Document Type: Article

References (40)

1. Baggiolini M, Schnyder J, Bretz U et al. Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins. Ciba Foundation Symposium 1980; 75:105-21.
2. Calafat J, Goldschmeding R, Ringeling PL et al. In situ localization by double-labeling immunoelectron microscopy of anti-neutrophil cytoplasmic autoantibodies in neutrophils and monocytes. Blood 1990; 75:242-50.
3. Csernok E, Lüdemann J, Gross WL et al. Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis. Am J Pathol 1990; 137:1113-20.
4. Niles JL, McCluskey RT, Ahmad MF et al. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase. Blood 1989; 74:1888-93.
5. Goldschmeding R, van der Schoot CE, ten Bokkel Huinink D et al. Wegener's granulomatosis autoantibodies identify a novel diisopropyl-fluorophosphate-binding protein in the lysosomes of normal human neutrophils. J Clin Invest 1989; 84:1577-87.
6. Lüdemann J, Utecht B, Gross WL. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. J Exp Med 1990; 171:357-62.
7. Jenne DE, Tschopp J, Lüdemann J et al. Wegener's autoantigen decoded. Nature 1990; 346:520.
8. van der Woude FJ, Rasmussen N, Lobatto S et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1985; 1:425-9.
9. Wiik A. Delineation of a standard procedure for indirect immunofluorescence detection of ANCA. Apmis 1989; 97(Suppl. 6):12-13.
10. Hagen EC, Andrassy K, Csernok E et al. Development and standardization of solid phase assays for the detection of anti-neutrophil cytoplasmic antibodies (ANCA). A report on the second phase of an international cooperative study on the standardization of ANCA assays. J Immunol Methods 1996; 196:1-15.
11. Koderisch J, Andrassy K, Rasmussen N et al. 'False-positive' antineutrophil cytoplasmic antibodies in HIV infection. Lancet 1990; 335:1227-8.
12. Lesavre P. Antineutrophil cytoplasmic autoantihodies antigen specificity. Am J Kidney Dis 1991; 18:159-63.
13. Klaassen RJL, Goldschmeding R, Dolman KM et al. Anti-neutrophil cytoplasmic autoantibodies in patients with symptomatic HIV infection. Clin Exp Immunol 1992; 87:24-30.
14. Hauschild S, Schmitt WH, Csernok E et al. ANCA in systemic vasculitides, collagen vascular diseases, rheumatic disorders and inflammatory bowel diseases. Adv Exp Med Biol 1993; 336:245-51.
15. Segelmark M, Baslund B, Wieslander J. Some patients with antimyeloperoxidase autoantibodies have a C-ANCA pattern.. Clin Exp Immunol 1994; 96:458-65.
16. Yang JJ, Tuttle R, Falk RJ et al. Frequency of anti-bactericidal/permeability-increasing protein (BPI) and anti-azuroeidin in patients with renal disease. Clin Exp Immunol 1996; 105:125-31.
17. Zhao MH, Jones SJ, Lockwood CM. Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasm autoantibodies (ANCA) in vasculitis. Clin Exp Immunol 1996; 99:49-56.
18. Rasmussen N, Sjölin C, Isaksson B et al. An ELISA for the detection of anti-neutrophil cytoplasm antibodies (ANCA). J Immunol Methods 1990; 127:139-45.
19. Lüdemann J, Utecht B, Gross WL. Detection and quantitation of antineutrophil cytoplasm antibodies in Wegener's granulomatosis by ELISA using affinity-purified antigen. J Immunol Methods 1988; 114:167-74.
20. Wieslander J. How are antineutrophil cytoplasmic antibodies detected? Am J Kidney Dis 1991; 18:154-8.
21. Specks U, Homburger HA, DeRemee RA. Implications of c-ANCA testing for the classification of Wegener's granulomatosis: performance of different detection systems. Adv Exp Med Biol 1993; 336:65-70.
22. Baslund B, Segelmark M, Wiik A et al. Screening for anti-neutrophil cytoplasmic antibodies (ANCA): is indirect immunofluorescence the method of choice? Clin Exp Immunol 1995; 99:486-92.
23. Bini P, Gabay JE, Teitel A et al. Antineutrophil cytoplasmic autoantibodies in Wegener's granulomatosis recognize conformational epitopes on proteinase 3.. J Immunol 1992; 149:1409-15.
24. Szymkowiak CH, Johnston TW, Csernok E et al. Expression of the human autoantigen of Wegener's granulomatosis (PR3) in a baculovirus expression system. Biochem Biophys Res Commun 1996; 219:283-9.
25. Witko-Sarsat V, Halbwachs-Mecarelli L, Almeida RP et al. Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies. FEBS Letters 1996; 382:130-6.
26. Specks U, Fass DN, Fautsch MP et al. Recombinant human proteinase 3, the Wegener's autoantigen, expressed in HMC-1 cells is enzymatically active and recognized by c-ANCA. FEBS Letters 1996; 390:265-70.
27. Specks U, Homburger HA. Anti-neutrophil cytoplasmic antibodies. Mayo Clin Proc 1994; 69:1197-8.
28. Specks U, Wheatley CL, McDonald TJ et al. Anticytoplasmic autoantibodies in the diagnosis and follow-up of Wegener's granulomatosis. Mayo Clin Proc 1989; 64:28-36.
29. Jennette JC, Falk RJ, Andrassy K et al. Nomenclature of systemic vasculitides: the proposal of an international consensus conference. Arthritis Rheum 1994; 37:187-92.
30. Rao NV, Rao GV, Marshall BC et al. Biosynthesis and processing of proteinase 3 in U937 cells. J Biol Chem 1996; 271:2972-8.
31. Salvesen G, Enghild JJ. An unusual specificity in the activation of neutrophil serine proteinase zymogens. Biochemistry 1990; 29:5304-8.
32. Caputo A, Garner RS, Winkler U et al. Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide. J Biol Chem 1993; 268:17672-5.
33. McGuire MJ, Lipsky PE, Thiele DL. Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thial protease dipeptidyl peptidase I. J Biol Chem 1993; 268:2458-67.
34. Dikov MM, Springman EB, Yeola S et al. Processing of procarboxypeptidase A and other zymogens in murine mast cells. J Biol Chem 1994; 269:25897-904.
35. Smyth MJ, McGuire MJ, Thia KYT. Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I. J Immunol 1995; 154:6299-305.
36. Gullberg U, Lindmark A, Nilsson E et al. Processing of human cathepsin G after transfection to the rat basophilic/mast cell tumor line RBL. J Biol Chem 1994; 269:25219-25.
37. Gullberg U, Lindmark A, Lindgren G et al. Carboxy-terminal prodomain-deleted human leukocyte elastase and cathepsin G are efficiently targeted to granules and enzymatically activated in the rat basophilic/mast cell line RBL. J Biol Chem 1995; 270:12912-8.
38. Garwicz D, Lindmark A, Hellmark T et al. Characterization of the processing and granular targeting of human proteinase 3 after transfection to the rat RBL or the murine 32D leukemic cell lines. J Leuk Biol 1997; 61:113-23.
39. Hagen EC, Andrassy K, Csernok E et al. The value of indirect immunofluorescence and solid phase techniques for ANCA detection. A report on the first phase of an international cooperative study on the standardization of ANCA assays. J Immunol Methods 1993; 159:1-16.
40. Jennings JG, Chang L, Savige JA. Anti-proteinase 3 antibodies, their characterization and disease associations. Clin Exp Immunol 1994; 95:251-6.