Minimal variation in the Pfs28 ookinete antigen from philippine field isolates of Plasmodium falciparum

Molecular and Biochemical Parasitology

Volumn 87, Issue 1, 1997, Pages 97-99

  Hafalla, Julius Clemence R ^a   Santiago, Mario Luis O ^a   Pasay, Ma Cielo J ^a   Ramirez, Bernadette L ^a   Gozar, Mary Margaret G ^c   Saul, Allan ^b   Kaslow, David C ^c  

^a RESEARCH INSTITUTE FOR TROPICAL MEDICINE   (Philippines)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

28 kDa sexual stage antigen; Malaria; Ookinete; Pfs28; Plasmodium falciparum; Sequence variation; Transmission blocking vaccine

Indexed keywords

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGENIC VARIATION; ARTICLE; GENE SEQUENCE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PHILIPPINES; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ANTIGENIC VARIATION; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; DNA, PROTOZOAN; EPITOPES; HUMANS; MALARIA VACCINES; MALARIA, FALCIPARUM; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; POINT MUTATION; PROTOZOAN PROTEINS;

PLASMODIUM FALCIPARUM;

EID: 0030739502     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00042-X     Document Type: Article

References (13)

1. D.C. Kaslow, Transmission-blocking immunity against malaria and other vector borne diseases, Curr. Opin. Immun. 5 (1993) 557-565.
2. R. Carter, N. Kumar, I.A. Quakyi, M.F. Good, K.N. Mendis, P.M. Graves, L.H. Miller, Immunity to sexual stages of malaria parasites, Prog. Allergy 41 (1988) 193-214.
3. P.E. Duffy, D.C. Kaslow, A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines, Infect. Immun. 65 (1997) 1109-1113.
4. P.D. Duffy, P. Pimenta, D.C. Kaslow, Pgs28 belongs to a family of epidermal growth factor-like antigens that are targets of malaria transmission-blocking antibodies, J. Exp. Med. 177 (1993) 505-510.
5. M.G. Platon, G.C. Barker, H. Matsuoka, J. Ramesar, C.J. Janse, A.P. Waters, R.E. Sinden, Structure and expression of a post-transcriptionally regulated malaria gene encoding a surface protein from the sexual stages of Plasmodium berghei, Mol. Biochem. Parasitol. 59 (1993) 263-276.
6. L.H. Miller, T. Roberts, M. Shahabuddin, T.F. McCutchan, Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1), Mol. Biochem. Parasitol. 59 (1993) 1-14.
7. J.A. Smythe, R.L. Coppel, K.P. Day, R.K. Martin, A.M.J. Odula, D.J. Kemp, R.F. Anders, Structural diversity in the Plasmodium falciparum merozoite surface antigen-2, Proc. Natl. Acad. Sci. USA 88 (1991) 1751-1755.
8. Q. Cheng, A. Stower, T.Y. Huang, D. Bustos, Y.M. Huang, C. Rzepczyk, A. Saul, Polymorphism in P. vivax MSA-1 gene- the result of intragenie recombinations?, Parasitology 106 (1993) 335-345.
9. R.K. Saiki, D.H. Gelfand, S. Stoffel, S.J. Scharf, R Higuchi, G.T. Horn, K.B. Mullis, H.A. Erlich, Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase, Science 239 (1988) 487-491.
10. D.C. Kaslow, I.A. Quakyi, C. Syin, M.G. Raum, D.B. Keister, J.E. Coligan, T.F. McCutchan, L.H. Miller, A vaccine candidiate from the sexual stage of human malaria that contains EGF-like domains, Nature 333 (1988) 74-76.
11. D.C. Kaslow, I.A. Quakyi, D.B. Keister, Minimal variation in a vaccine candidiate from the sexual stage of Plasmodium falciparum, Mol. Biochem. Parasitol. 32 (1989) 101-104.
12. S. Ya-Ping, M.P. Alpers, M.M. Povoa, A.A. Lal, Single amino acid variation in the ookinete vaccine antigen from field isolates of Plasmodium falciparum, Mol. Biochem. Parasitol. 50 (1992) 179-180.
13. 19) variants secreted from Saccharomyces cerevisiae, Mol. Biochem. Parasitol. 63 (1994) 283-289.