Alteration of hepatic microcirculation by oxethazaine and some vasoconstrictors in the perfused rat liver

Biochemical Pharmacology

Volumn 53, Issue 12, 1997, Pages 1779-1787

  Masuda, Yasusuke ^a   Ozaki, Masanobu ^a   Oguma, Tamami ^a  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

Author keywords

Acridine orange staining; Hepatic perfusion disturbance; Oxethazaine; Portal pressure increase; Vasoconstrictors

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACRIDINE ORANGE; ENDOTHELIN 1; ET 1; OXETACAINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG DISTRIBUTION; HEMODYNAMICS; HEPATIC VEIN; ISOLATED LIVER; LIVER CIRCULATION; LIVER PERFUSION; NONHUMAN; OXYGEN CONSUMPTION; PORTAL HYPERTENSION; PORTAL VEIN; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT; STAINING;

ACRIDINE ORANGE; ANIMALS; BLOOD PRESSURE; COLORING AGENTS; ETHANOLAMINES; FLUORESCENCE; LIVER; LIVER CIRCULATION; MALE; MICROCIRCULATION; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTOR AGENTS;

EID: 0030739459     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00001-4     Document Type: Article

References (36)

1. Campra JL and Reynolds TB, The hepatic circulation. In: The Liver: Biology and Pathobiology (Eds. Arias IM, Jakoby WB, Popper H, Schachter D and Shafritz DA), 2nd Edn, pp. 911-930. Raven Press, New York, 1988.
2. 2+ mobilization in the perfused rat liver. Eur J Biochem 165: 455-460, 1987.
3. Häussinger D, Stehle T and Gerok W, Actions of extracellular UTP and ATP in perfused rat liver: A comparative study. Eur J Biochem 167: 65-71, 1987.
4. 2 analogue U-46619. J Biol Chem 262: 4631-4638, 1987.
5. 2 analogue U-46619 in isolated perfused rat liver: Metabolic, hemodynamic and ion-flux responses. Biol Chem Hoppe Seyler 369: 97-107, 1988.
6. Gandhi CR, Stephenson K and Olson MS, Endothelin, a potent peptide agonist in the liver. J Biol Chem 265: 17432-17435, 1990.
7. Tran-Thi T-A, Kawada N and Decker K, Regulation of endothelin-1 action on the perfused rat liver. FEBS Lett 318: 353-357, 1993.
8. Buxton DB, Hanahan DJ and Olson MS, Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. Biochem Pharmacol 35: 893-897, 1986.
9. Lapointe DS and Olson MS, Alteration of hepatic tissue spaces by platelet-activating factor and phenylephrine. Hepatology 9: 278-284, 1989.
10. Farrar GE Jr and Seifter J, Gastrointestinal dysfunction modified by a topical anesthetic (oxethazaine). Pennsylvania Med J 65: 1369-1372, 1962.
11. Seifter J, Glassman JM and Hudyma GM, Oxethazaine and related congeners: A series of highly potent local anesthetics. Proc Soc Exp Biol Med 109: 664-668, 1962.
12. Posey EL Jr, Boler K and Posey L III, Inhibition of acetylcholine-stimulated gastrin release by the topical anesthetic, oxethazaine. Am J Gastroenterol 55: 54-57, 1971.
13. Masuda Y, Yoshizawa T, Ozaki M and Tanaka T, The metabolic and hemodynamic effects of oxethazaine in the perfused rat liver. Jpn J Pharmacol 70: 243-252, 1996.
14. Meier P and Zierler KL, On the theory of the indicator-dilution method for measurement of blood flow and volume. J Appl Physiol 6: 731-744, 1954.
15. Goresky CA, A linear method for determining liver sinusoidal and extravascular volumes. Am J Physiol 204: 626-640, 1963.
16. Menger MD, Vollmar B, Glasz J, Post S and Messmer K, Microcirculatory manifestations of hepatic ischemia/reperfusion injury. In: Progress in Applied Microcirculation (Eds. Messmer K and Menger MD), Vol. 19, pp. 106-124. Basel, Karger, 1993.
17. Murakami T, Itoshima T and Shimada Y, Peribiliary portal system in the monkey liver as evidenced by the injection replica scanning electron microscope method. Arch Histol Jap 37: 245-260, 1974.
18. Haratake J, Yamamoto O, Hisaoka M and Horie A, Scanning electron microscopic examinations of microvascular casts of the rat liver and bile duct. J Univ Occupat Environ Health 12: 19-28, 1990.
19. Reichen J, Assessment of liver microcirculation with the multiple indicator dilution technique. In: Progress in Applied Microcirculation (Eds. Messmer K and Menger MD), Vol. 19, pp. 40-51. Basel, Karger, 1993.
20. Groszmann RJ, Vorobioff J and Riley E, Splanchnic hemodynamics in portal-hypertensive rats: Measurement with γ-labeled microspheres. Am J Physiol 242: G156-G160, 1982.
21. Reichen J, Egger B, Ohara N, Zeltner TB, Zysset T and Zimmermann A, Determinants of hepatic function in liver cirrhosis in the rat: Multivariate analysis. J Clin Invest 82: 2069-2076, 1988.
22. Gariépy L, Fenyves D, Kassissia I and Villeneuve J-P, Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique. Hepatology 18: 823-831, 1993.
23. Varin F and Huet P-M, Hepatic microcirculation in the perfused cirrhotic rat liver. J Clin Invest 76: 1904-1912, 1985.
24. MacPhee PJ, Schmidt EE and Groom AC, Organization and flow in the liver microcirculation. In: Progress in Applied Microcirculation (Eds. Messmer K and Menger MD), Vol. 19, pp. 52-73. Basel, Karger, 1993.
25. McCuskey RS, A dynamic and static study of hepatic arterioles and hepatic sphincters. Am J Anat 119: 455-477, 1966.
26. Oda M, Kaneko H, Suematsu M, Suzuki H, Kazemoto S, Honda K, Yonei Y and Tsuchiya M, A new aspect of the hepatic microvasculature: Electron-microscopic evidence for the presence of Ito cells around portal and hepatic venules as pericytes. In: Progress in Applied Microcirculation (Eds. Messmer K and Menger MD), Vol. 19, pp. 25-39. Basel, Karger, 1993.
27. Rockey DC, Housset CN and Friedman SL, Activation-dependent contractility of rat lipocytes in culture and in vivo. J Clin Invest 92: 1795-1804, 1993.
28. Kawada N, Tran-Thi T-A, Klein H and Decker K, The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances: Possible involvement of endothelin 1 and nitric oxide in the regulation of sinusoidal tonus. Eur J Biochem 213: 815-823, 1993.
29. Housset C, Rockey D and Bissell M, Endothelin receptors in rat liver: Lipocytes as a contractile target for endothelin 1. Proc Natl Acad Sci USA 90: 9266-9270, 1993.
30. Kawada N, Klein H and Decker K, Eicosanoid-mediated contractility of hepatic stellate cells. Biochem J 285: 367-371, 1992.
31. Pianzani M, Failli P, Ruocco C, Casini A, Milani S, Baldi E, Giotti A and Gentilini P, Fat-storing cells as liver-specific pericytes. J Clin Invest 90: 642-646, 1992.
32. Wisse E, Geerts A, Van Der Smissen P, Van Bossuyt H, Schellinck P, Jacobs R and De Zanger RB, On the role of the cytoskeleton and the extracellular matrix in the function of endothelial cells in liver sinusoids. J Electron Microsc (Tokyo) 35 (Suppl): 1945-1947, 1986.
33. Gatmaitan Z and Arias IM, Hepatic endothelial cell fenestrae. In: Cells of the Hepatic Sinusoid (Eds. Knook DL and Wisse E), Vol. 4, pp. 3-7. Kupffer Cell Foundation, Leiden, 1993.
34. Wisse E, De Zanger RB, Charels P, Van Der Smissen P and McCuskey RS, The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 5: 683-692, 1985.
35. Bauer M, Zhang JX, Bauer I and Clemens MG, ET-1 induced alterations of hepatic microcirculation: Sinusoidal and extra-sinusoidal sites of action. Am J Physiol 267: G143-G149, 1994.
36. Glassman JM, Dervinis A, Beckfield WJ and Seifter J, Acute and chronic toxicity of oxethazaine: A highly potent local anesthetic. Toxicol Appl Pharmacol 5: 184-200, 1963.