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Volumn 43, Issue 4, 1997, Pages 232-241

The age-related rise of plasma cholesterol in humans is not caused by a cell removal defect of ldl particles: ‘In vitro’ studies in peripheral mononuclear blood cells

Author keywords

Aging; Cholesterol; Cholesterol synthesis; Low density lipoprotein metabolism; Low density lipoprotein receptors; Mononuclear cells

Indexed keywords

ACETIC ACID; APOLIPOPROTEIN B; CARBON 14; CHOLESTEROL; CHOLESTEROL OLEATE; IODINE 125; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; VERY LOW DENSITY LIPOPROTEIN;

EID: 0030739408     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000213855     Document Type: Article
Times cited : (1)

References (59)
  • 1
    • 0026342525 scopus 로고
    • Clinical considerations regarding treatment of hypercholesterolemia in the elderly
    • Bilhcimer DW: Clinical considerations regarding treatment of hypercholesterolemia in the elderly. Atherosclerosis 1991;91(suppl):35-37.
    • (1991) Atherosclerosis , vol.91 , pp. 35-37
    • Bilhcimer, D.W.1
  • 4
    • 0023665488 scopus 로고
    • Cholesterol metabolism and aging
    • Krcisberg RA, Kasim S: Cholesterol metabolism and aging. Am J Med 1987:82:54-60.
    • (1987) Am J Med , vol.82 , pp. 54-60
    • Krcisberg, R.A.1    Kasim, S.2
  • 5
    • 0022392824 scopus 로고
    • Risk factors for ischaemic heart disease in men and women
    • Carlson LA, Bdttiger LE: Risk factors for ischaemic heart disease in men and women. Acta Med Scand 1985:218:207-211.
    • (1985) Acta Med Scand , vol.218 , pp. 207-211
    • Carlson, L.A.1    Bdttiger, L.E.2
  • 7
    • 0025019678 scopus 로고
    • Is elevated serum cholesterol level a risk factor for coronary heart disease in the elderly?
    • Benfante R, Reed D: Is elevated serum cholesterol level a risk factor for coronary heart disease in the elderly? JAMA 1990;263:393-396.
    • (1990) JAMA , vol.263 , pp. 393-396
    • Benfante, R.1    Reed, D.2
  • 9
    • 0023121401 scopus 로고
    • Cholesterol and mortal ly: 30 years of follow-up from The Framingham Study
    • Anderson KM, Castelli WP, Levy D: Cholesterol and mortal ly: 30 years of follow-up from The Framingham Study. JAMA 1987:257: 2176-2180.
    • (1987) JAMA , vol.257 , pp. 2176-2180
    • Erson, K.M.1    Castelli, W.P.2    Levy, D.3
  • 11
    • 0016864308 scopus 로고
    • Plasma lipids and lipoproteins in vegetarians and controls
    • Sacks FM, Castelli WP, Donncr A, Kass EH: Plasma lipids and lipoproteins in vegetarians and controls. N Engl J Med 1975:292:1148-1151.
    • (1975) N Engl J Med , vol.292 , pp. 1148-1151
    • Sacks, F.M.1    Castelli, W.P.2    Donncr, A.3    Kass, E.H.4
  • 12
    • 0015885506 scopus 로고
    • Epidemi-logical studies in a total highland population. Tukisenta. New Guinea: Cardiovascular disease and relevant clinical, electrocardiographic, radiological and biochemical findings
    • Sinnett PF, Whyte HM: Epidemi-logical studies in a total highland population. Tukisenta. New Guinea: Cardiovascular disease and relevant clinical, electrocardiographic, radiological and biochemical findings. J Chronic Dis 1973:26:265-290.
    • (1973) J Chronic Dis , vol.26 , pp. 265-290
    • Sinnett, P.F.1    Whyte, H.M.2
  • 13
    • 0010523016 scopus 로고
    • Scrum lipid levels among rural Guatemalan Indians
    • Mendez J, Tejada C, Flores M: Scrum lipid levels among rural Guatemalan Indians. Am J Clin Nutr 1962:10:403-409.
    • (1962) Am J Clin Nutr , vol.10 , pp. 403-409
    • Mendez, J.1    Tejada, C.2    Flores, M.3
  • 14
    • 0022404596 scopus 로고
    • Kinetic mechanisms determining variability in low density lipoprotein levels and rise with age
    • Grundy SM, Vega GL, Bilheimer DW: Kinetic mechanisms determining variability in low density lipoprotein levels and rise with age. Arteriosclerosis 1985:5:623-630.
    • (1985) Arteriosclerosis , vol.5 , pp. 623-630
    • Grundy, S.M.1    Vega, G.L.2    Bilheimer, D.W.3
  • 15
    • 0021358658 scopus 로고
    • Why does plasma low density lipoprotein concentration in adults increase with age?
    • Miller NE: Why does plasma low density lipoprotein concentration in adults increase with age? Lancet 1984;i:263-267.
    • (1984) Lancet , vol.1 , pp. 263-267
    • Miller, N.E.1
  • 18
    • 0019802002 scopus 로고
    • Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man
    • Mahley RW, Hui DY, Inncrarity TL, Wcisgraber KH: Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. J Clin Invest 1981:68:1197-1206.
    • (1981) J Clin Invest , vol.68 , pp. 1197-1206
    • Mahley, R.W.1    Hui, D.Y.2    Inncrarity, T.L.3    Wcisgraber, K.H.4
  • 19
    • 0018743322 scopus 로고
    • Effect of donor age on the binding and degradation of low density lipoprotein by cultured human arterial smooth muscle cells
    • Bierman EL, Albers JL, Chait A: Effect of donor age on the binding and degradation of low density lipoprotein by cultured human arterial smooth muscle cells. J Gerontol 1979;34:483-488.
    • (1979) J Gerontol , vol.34 , pp. 483-488
    • Bierman, E.L.1    Albers, J.L.2    Chait, A.3
  • 21
    • 0017161065 scopus 로고
    • Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes
    • Ho YK, Brown MS, Bilheimer DW, Goldstein JL: Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes. J Clin Invest 1976:58:1465-1474.
    • (1976) J Clin Invest , vol.58 , pp. 1465-1474
    • Ho, Y.K.1    Brown, M.S.2    Bilheimer, D.W.3    Goldstein, J.L.4
  • 22
    • 0022644326 scopus 로고
    • Detection of familial hypercholesterolemia by assaying functional low-density-lipoprotein receptors on lymphocytes
    • Cuthbert JA, East CA, Bilheiner DW, Lipsky PE: Detection of familial hypercholesterolemia by assaying functional low-density-lipoprotein receptors on lymphocytes. N Engl J Med 1986:314:879-983.
    • (1986) N Engl J Med , vol.314 , pp. 879-983
    • Cuthbert, J.A.1    East, C.A.2    Bilheiner, D.W.3    Lipsky, P.E.4
  • 23
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown MS, Goldstein JL: A receptor-mediated pathway for cholesterol homeostasis. Science 1986:232: 34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 24
    • 0017656801 scopus 로고
    • Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes
    • Ho IK, Faust JR, Bilheiner DW, Borwn MS, Goldstein JL: Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. J Exp Med 1977; 145:1531-1549.
    • (1977) J Exp Med , vol.145 , pp. 1531-1549
    • Ho, I.K.1    Faust, J.R.2    Bilheiner, D.W.3    Borwn, M.S.4    Goldstein, J.L.5
  • 25
    • 0027501003 scopus 로고
    • Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans
    • Dietschy JM, Turley SD, Spadv DK: Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 1993:34:1637-1659.
    • (1993) J Lipid Res , vol.34 , pp. 1637-1659
    • Dietschy, J.M.1    Turley, S.D.2    Spadv, D.K.3
  • 26
    • 0028212483 scopus 로고
    • Low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl cocnzymc A reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in human liver
    • Powell EE, Kroon PA: Low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl cocnzymc A reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in human liver. J Clin Invest 1994,93:2168-2174.
    • (1994) J Clin Invest , vol.93 , pp. 2168-2174
    • Powell, E.E.1    Kroon, P.A.2
  • 27
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chcm 1972;18:499-502.
    • (1972) Clin Chcm , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 28
    • 33745026603 scopus 로고
    • Distribution and chemical composition of ullracentrifugally separated lipoproteins in human serum
    • Havel RJ, Eder HA, Bragdon JH: Distribution and chemical composition of ullracentrifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-1353.
    • (1955) J Clin Invest , vol.34 , pp. 1345-1353
    • Havel, R.J.1    Eder, H.A.2    Bragdon, J.H.3
  • 30
    • 0014385564 scopus 로고
    • Isolation of mononuclear cells and granulocytes from human blood
    • Bôyum A: Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968;21 (suppl 97):77-89.
    • (1968) Scand J Clin Lab Invest , vol.21 , pp. 7-89
    • Bôyum, A.1
  • 31
    • 34548003946 scopus 로고
    • Efficient trace-labelling of proteins with iodine
    • McFarlanc AS: Efficient trace-labelling of proteins with iodine. Nature 1958:182:53.
    • (1958) Nature , vol.182 , pp. 53
    • McFarlanc, A.S.1
  • 32
    • 0019944767 scopus 로고
    • Low density lipoprotein receptor activity in freshly isolated human blood monocytes and lymphocytes
    • Chait A, Henze K, Mazzone T, Jensen M, Hammond W: Low density lipoprotein receptor activity in freshly isolated human blood monocytes and lymphocytes. Metabolism 1982;31:721-727.
    • (1982) Metabolism , vol.31 , pp. 721-727
    • Chait, A.1    Henze, K.2    Mazzone, T.3    Jensen, M.4    Hammond, W.5
  • 33
    • 0024806282 scopus 로고
    • In vitro incorporation of radiolabeled cholesteryl esters into high and low density lipoproteins
    • Terpsira AHM, Nicolosi RJ, Herbert PN: In vitro incorporation of radiolabeled cholesteryl esters into high and low density lipoproteins. J Lipid Res 1989:30:1663-1671.
    • (1989) J Lipid Res , vol.30 , pp. 1663-1671
    • Terpsira, A.1    Nicolosi, R.J.2    Herbert, P.N.3
  • 34
    • 0022556177 scopus 로고
    • Synthesis of ether analogs of lipoprotein lipids and their biological applications
    • Halpcrin G, Stein O, Stein Y: Synthesis of ether analogs of lipoprotein lipids and their biological applications. Methods Enzymol 1986:129: 816-848.
    • (1986) Methods Enzymol , vol.129 , pp. 816-848
    • Halpcrin, G.1    Stein, O.2    Stein, Y.3
  • 35
    • 0018822640 scopus 로고
    • In vitro cholesterol synthesis in freshly isolated mononuclear cells of human blood: Effect of in vivo administration of clofibrate and or cholestyramine
    • McNamara DJ, Davidson NO, Fernandez S: In vitro cholesterol synthesis in freshly isolated mononuclear cells of human blood: Effect of in vivo administration of clofibrate and or cholestyramine. J Lipid Res 1980;21:65-71.
    • (1980) J Lipid Res , vol.21 , pp. 65-71
    • McNamara, D.J.1    Davidson, N.O.2    Fernandez, S.3
  • 36
    • 0028930651 scopus 로고
    • Selective uptake of low-density lipoprotein-associated cholesteryl esters by human fibroblasts, human Hep G2 hepatoma cells and J774 macrophages in culture
    • Rinninger F, Brundert M, Jackie S, Kaiser T, Gretcn H: Selective uptake of low-density lipoprotein-associated cholesteryl esters by human fibroblasts, human Hep G2 hepatoma cells and J774 macrophages in culture. Biochim Biophys Acta 1995:1255:141-153.
    • (1995) Biochim Biophys Acta , vol.1255 , pp. 141-153
    • Rinninger, F.1    Brundert, M.2    Jackie, S.3    Kaiser, T.4    Gretcn, H.5
  • 37
    • 0018918106 scopus 로고
    • Lipoprotcin-cholcsterol distributions in selected North American populations. The Lipid Research Clinics Program Prevalence Study
    • Heiss G, Tamir I, Davis CE, Tyroler HA, Rifkind BM, Schonfcld G, Jacobs D, Franz ID Jr: Lipoprotcin-cholcsterol distributions in selected North American populations. The Lipid Research Clinics Program Prevalence Study. Circulation 1980; 61:302-315.
    • (1980) Circulation , vol.61 , pp. 302-315
    • Heiss, G.1    Tamir, I.2    Davis, C.E.3    Tyroler, H.A.4    Rifkind, B.M.5    Schonfcld, G.6    Jacobs, D.7    Franz, I.D.8
  • 38
    • 0014976138 scopus 로고
    • Serum cholesterol. Lipoproteins, and the risk of coronary heart disease
    • Kannel WB, Castelli WP, Gordon T, McNamara PM: Serum cholesterol. lipoproteins, and the risk of coronary heart disease. Ann Intern Med 1971:74:1-12.
    • (1971) Ann Intern Med , vol.74 , pp. 1-12
    • Kannel, W.B.1    Castelli, W.P.2    Gordon, T.3    McNamara, P.M.4
  • 39
    • 0021350001 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial result’s
    • Lipid Research Clinics Programs: The Lipid Research Clinics Coronary Primary Prevention Trial result’s. JAMA 1984:251:351-364.
    • (1984) JAMA , vol.251 , pp. 351-364
  • 40
    • 0018949549 scopus 로고
    • Prevalence of coronary heart disease in The Framingham Offspring Study: Role of lipoprotein cholestérols
    • Wilson PW, Garrison RJ, Castelli WP, Feinleib M, McNamara PM, Kannel WB: Prevalence of coronary heart disease in The Framingham Offspring Study: Role of lipoprotein cholestérols. Am J Cardiol 1980:46: 649-654.
    • (1980) Am J Cardiol , vol.46 , pp. 649-654
    • Wilson, P.W.1    Garrison, R.J.2    Castelli, W.P.3    Feinleib, M.4    McNamara, P.M.5    Kannel, W.B.6
  • 43
    • 85034620278 scopus 로고
    • Lack of correlation between the maximum low-density lipoprotein (LDL) receptor activity of blood lymphocytes and plasma LDL concentration in normal men
    • Cortese C, Turner PR, Marenah CB, Suie U, Price S, Miller NE, Lewis B: Lack of correlation between the maximum low-density lipoprotein (LDL) receptor activity of blood lymphocytes and plasma LDL concentration in normal men. Clin Sei 1983:65:65-98.
    • (1983) Clin Sei , vol.65 , pp. 65-98
    • Cortese, C.1    Turner, P.R.2    Marenah, C.B.3    Suie, U.4    Price, S.5    Miller, N.E.6    Lewis, B.7
  • 45
    • 0022527066 scopus 로고
    • Regulation of plasma levels of low-density lipoprotein cholesterol: Interpretation of data on low-density lipoprotein turnover in man
    • Meddings JB, Dietschy JM: Regulation of plasma levels of low-density lipoprotein cholesterol: Interpretation of data on low-density lipoprotein turnover in man. Circulation 1986;74:805-814.
    • (1986) Circulation , vol.74 , pp. 805-814
    • Meddings, J.B.1    Dietschy, J.M.2
  • 47
    • 0019469959 scopus 로고
    • Individual variation in the effects of dietary cholesterol on plasma lipoproteins and cellular cholesterol homeostasis in man
    • Mistry P, Miller NE, Laker M, Haz-zard WR, Lewis B: Individual variation in the effects of dietary cholesterol on plasma lipoproteins and cellular cholesterol homeostasis in man. J Clin Invest 1981;67:493-502.
    • (1981) J Clin Invest , vol.67 , pp. 493-502
    • Mistry, P.1    Miller, N.E.2    Laker, M.3    Haz-Zard, W.R.4    Lewis, B.5
  • 49
    • 0021811872 scopus 로고
    • Influence of age on secretion of cholesterol and synthesis of bile acids by the liver
    • Einarsson K, Nilsell K, Leijd B, Angelin B: Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med 1985;313:277-282.
    • (1985) N Engl J Med , vol.313 , pp. 277-282
    • Einarsson, K.1    Nilsell, K.2    Leijd, B.3    Angelin, B.4
  • 50
    • 0024496496 scopus 로고
    • Effect of combined therapy with bezafi-brate and cholestyramine on low-density lipoprotein metabolism in type 11“hypercholesterolemia
    • Series JJ, Caslake MJ, Kilday C, Cruickshank A, Dcmant T, Lorimer AR, Packard CJ, Shepherd J: Effect of combined therapy with bezafi-brate and cholestyramine on low-density lipoprotein metabolism in type 11“hypercholesterolemia. Metabolism 1989;38:153-158.
    • (1989) Metabolism , vol.38 , pp. 153-158
    • Series, J.J.1    Caslake, M.J.2    Kilday, C.3    Cruickshank, A.4    Dcmant, T.5    Lorimer, A.R.6    Packard, C.J.7    Shepherd, J.8
  • 51
    • 0018839053 scopus 로고
    • Cholestyramine promotes receptor-mediated low-density lipoprotein catabolism
    • Shepherd J, Packard CJ, Bicker S, Lawrie TDV, Morgan HG: Cholestyramine promotes receptor-mediated low-density lipoprotein catabolism. N Engl J Med 1980;302: 1219-1222.
    • (1980) N Engl J Med , vol.302 , pp. 1219-1222
    • Shepherd, J.1    Packard, C.J.2    Bicker, S.3    Lawrie, T.4    Morgan, H.G.5
  • 52
    • 0015335846 scopus 로고
    • Cholesterol distribution in the bulk tissues of man: Variation with age
    • Crouse JR, Grundy SM, Ahrens EH Jr: Cholesterol distribution in the bulk tissues of man: Variation with age. J Clin Invest 1972:51:1292-1296.
    • (1972) J Clin Invest , vol.51 , pp. 1292-1296
    • Crouse, J.R.1    Grundy, S.M.2    Ahrens, E.H.3
  • 53
    • 0024401216 scopus 로고
    • Age-related changes in the lipid compositions of rat and human tissues
    • Kalcn A, Appclkvist EL, Dallner G: Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989;24:579-584.
    • (1989) Lipids , vol.24 , pp. 579-584
    • Kalcn, A.1    Appclkvist, E.L.2    Dallner, G.3
  • 54
    • 0021717457 scopus 로고
    • Liver transplantation to provide low-den-sity lipoprotein receptors and lower plasma cholesterol in a child with homozygous hypercholesterolemia
    • Bilheimer DW, Goldstein JL, Grundy SM, Starzl TE, Brown MS: Liver transplantation to provide low-den-sity lipoprotein receptors and lower plasma cholesterol in a child with homozygous hypercholesterolemia. N Engl J Med 1984;311:1658-1664.
    • (1984) N Engl J Med , vol.311 , pp. 1658-1664
    • Bilheimer, D.W.1    Goldstein, J.L.2    Grundy, S.M.3    Starzl, T.E.4    Brown, M.S.5
  • 55
    • 0027717922 scopus 로고
    • Variability in cholesterol content and physical properties of lipoproteins containing apolipoprotein B-100
    • Abate N, Vega GI-, Grundy SM: Variability in cholesterol content and physical properties of lipoproteins containing apolipoprotein B-100. Atherosclerosis 1993; 104:159-171.
    • (1993) Atherosclerosis , vol.104 , pp. 159-171
    • Abate, N.1    Vega, G.2    Grundy, S.M.3
  • 56
    • 0025313659 scopus 로고
    • Inheritance of low-den-sity lipoprotein subclass pattern in familial combined hyperlipidemia
    • Austin MA, Brunzell JD, Fitch WL, Krauss RM: Inheritance of low-den-sity lipoprotein subclass pattern in familial combined hyperlipidemia. Arteriosclerosis 1990:10:520-530.
    • (1990) Arteriosclerosis , vol.10 , pp. 520-530
    • Austin, M.A.1    Brunzell, J.D.2    Fitch, W.L.3    Krauss, R.M.4
  • 57
    • 0026734295 scopus 로고
    • Correlations of plasma lipoproteins with LDL subfractions by particle size in men and women
    • Williams PT, Vranizan KM, Krauss RM: Correlations of plasma lipoproteins with LDL subfractions by particle size in men and women. J Lipid Res 1992;33:765-774.
    • (1992) J Lipid Res , vol.33 , pp. 765-774
    • Williams, P.T.1    Vranizan, K.M.2    Krauss, R.M.3
  • 58
    • 0026354754 scopus 로고
    • Multifactorial etiology of hypercholesterolemia
    • Grundy SM: Multifactorial etiology of hypercholesterolemia. Arterio-sclerThromb 1991;11:1619-1635.
    • (1991) Arterio-Sclerthromb , vol.11 , pp. 1619-1635
    • Grundy, S.M.1
  • 59
    • 0013880360 scopus 로고
    • Overweight and triglyceride level in normal persons and patients with diabetes mcllitus
    • Sailer S, Sandhofer F, Braunsteiner H: Overweight and triglyceride level in normal persons and patients with diabetes mcllitus. Metabolism 1966; 15:135-137.
    • (1966) Metabolism , vol.15 , pp. 135-137
    • Sailer, S.1    Sandhofer, F.2    Braunsteiner, H.3


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