N-cadherin protein distribution in normal embryos and in embryos carrying mutations in the homeobox gene Hoxa-4

International Journal of Developmental Biology

Volumn 41, Issue 3, 1997, Pages 459-468

  Packer, Alan I ^a   Elwell, Vivian A ^a   Parnass, Jeffrey D ^a   Knudsen, Karen A ^b   Wolgemuth, Debra J ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Embryogenesis; Hoxa 4; Immunohistochemistry; N cadherin

Indexed keywords

CADHERIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHICK EMBRYO; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; GENE TARGETING; HOMEOBOX; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CADHERINS; DNA-BINDING PROTEINS; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; IMMUNOENZYME TECHNIQUES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MUTATION;

ANIMALIA; VERTEBRATA;

EID: 0030739085     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. BEHRINGER, R.R., CROTTY, D A, TENNYSON, V.M., BRINSTER, R L., PALMITER, RD and WOLGEMUTH, D J (1993). Sequences 5′ of the homeobox of the Hox-1 4 gene direct tissue-specific expression of lacZ during mouse development. Development 117: 823-833
2. BIRCHMEIER, W., WEIDNER, K.M. and BEHRENS, J (1993). Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells. J Cell Sci 17 (Suppl). 159-164.
3. BIXBY, J.L. and ZHANG, R (1990). Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth. J. Cell Biol. 110: 1253-1260
4. BYERS, S and BLASCHUK, O W (1993). Sertoli cell adhesion molecules and the collective organization of the testis In The Sertoli Cell (Eds L D. Russell and M.D Griswold) Cache River Press, Clearwater, pp. 461-476.
5. CLOUTHIER, D.E., AVARBOCK, M.R , MAIKA,S D., HAMMER, R.E and BRINSTER, R.L (1996) Rat spermatogenesis in mouse testis. Nature 381: 418-421.
6. DAVIS, A.P , WITTE, D.P , HSIEH-LI, H.M., POTTER, S.S. and CAPECCHI, M.R (1995) Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375: 791-795.
7. EDELMAN, G M. (1988). Topobiology. An Introduction to Molecular Embryology. Basic Books, New York.
8. GALLIOT, B., DOLLE, P., VIGNERON, M., FEATHERSTONE, M.S., BARON, A. and DUBOULE, D (1989) The mouse Hox-1.4 gene, primary structure, evidence for promoter activity and expression during development. Development 107: 343-359.
9. GOMPERTS, M., GARCIA-CASTRO, M., WYLIE, C. and HEASMAN, J (1994). Interactions between primordial germ cells play a role in their migration in mouse embryos. Development 120: 135-141.
10. GOOMER, R.S., HOLST, B D , WOOD, I.C., JONES, F.S and EDELMAN, G.M. (1994). Regulation in vitro of an L-CAM enhancer by homeobox genes Hoxd-9and HNF-1. Proc. Natl Acad Sci USA 91: 7985-7989
11. HATTA, K and TAKEICHI, M. (1986). Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature 320: 447-449.
12. HATTA, K., OKAOA, T.S. and TAKEICHI, M. (1985). A monoclonal antibody disrupting calcium-dependent cell-cell adhesion of brain tissues: possible role of its target antigen in animal pattern formation. Proc. Natl. Acad. Sci. USA 80: 1038-1042
13. HATTA, K , TAKAGI, S., FUJISAWA, H. and TAKEICHI, M. (1987). Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos. Dev. Biol. 120: 215-227.
14. HERMISTON, M.L. and GORDON, J.I (1995) Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270: 1203-1207.
15. HOLT, C.E., LEMAIRE, P. and GURDON, J B. (1994). Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm. Proc Natl. Acad. Sci. USA 91: 10844-10848.
16. HORAN, G.S B., RAMIREZ-SOLIS. R , FEATHERSTONE, M.S., WOLGEMUTH, D.J., BRADLEY, A. and BEHRINGER, R.R. (1995). Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev. 9: 1667-1677.
17. HORAN, G.S.B., WU, K., WOLGEMUTH, D.J and BEHRINGER, R.R. (1994) Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice. Proc. Natl. Acad Sci USA 91: 12644-12648.
18. HSIEH-LI, H.M., WITTE, D.P , WEINSTEIN, M., BRADFORD, W., LI, H., SMALL, K. and POTTER, S.S. (1995). Hoxa-11 structure, extensive antisense transcription, and function in male and female fertility. Development 121: 1373-1385.
19. INIZUKA, H., MIYATANI, S. and TAKEICHI, M. (1991a) R-cadherin: a novel calcium-dependent cell-cell adhesion molecule expressed in the retina. Neuron 7: 69-79.
20. INIZUKA, H., REDIES, C and TAKEICHI, M. (1991b) Differential expression of R- and N-cadherin in neural and mesodermal tissues during early chicken development. Development 113: 959-967.
21. KAPUR, R.P., LIVINGSTON, R , DOGGETT, B , SWEETSER, D.A., SIEBERT, J.R. and PALMITER, R.D. (1996). Abnormal microenvironmental signals underlie intestinal aganglionosis in Dominant megacolon mutant mice Dev Biol. 174: 360-369.
22. KAPUR, R.P., SWEETSER, D A., DOGGETT, B., SIEBERT, J.R and PALMITER, R D. (1995). Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts. Development 121: 3787-3795.
23. KEMLER, R (1992). Classical cadherins. Semin Cell Biol. 3: 149-155
24. KINTNER, C. (1992). Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain Cell 69: 225-236
25. KNUDSEN, K.A., MAYERS, L. and MCELWEE, S.A (1990). A role for the calcium-dependent adhesion molecule, N-cadherin, in myoblast interaction during myogenesis Exp. Cell Res. 188: 175-184
26. KNUDSEN, K.A , PERALTA SOLER, A., JOHNSON, K.R. and WHEELOCK, M J. (1995). Interaction of α-actinin with the cadherin/catenin cell-cell adhesion complex via a-catenin. J. Cell Biol. 130: 67-77.
27. LARUE, L.,OHSUGI, M., HIRCHENHAIN, J. and KEMLER, R. (1994) E-cadherin null mutant embryos fail to form a trophectoderm epithelium Proc Natl Acad Sci. USA 91: 8263-8267.
28. MANAK, J.R and SCOTT, M.P (1994) A class act. conservation of homeodomain protein functions. Development (Suppl.): 61-71
29. MANLEY, N.R. and CAPECCHI, M.R (1995). The role of Hoxa-3 in mouse thymus and thyroid development Development 121: 1989-2003.
30. MATSUNAGA, M , HATTA, K. and TAKEICHI, M. (1988). Role of N-cadherin cell adhesion molecules in the histogenesis of neural retina. Neuron 1: 289-295
31. MIYATANI, S , SHIMAMURA, K., HATTA, M , NAGAFUCHI, A., NOSE, A., MATSUNAGA, M., HATTA, K. and TAKEICHI, M (1989) Neural cadherin: role in selective cell-cell adhesion. Science 245: 631-635.
32. NEUGEBAUER, K.M., TOMASELLI, K.J., LILIEN, J and REICHARDT, L.F (1988). N-cadherin, N-CAM, and integrins promote retinal neunte outgrowth on astrocytes in vitro. J. Cell Biol. 197: 1177-1187
33. NEWTON, S.C., BLASCHUK, O.W and MILLETTE, C.F. (1993). N-cadherin mediates Sertoli cell-spermatogenic cell adhesion. Dev. Dynamics 197: 1-13
34. OBERLENDER, S.A. and TUAN, R.S. (1994). Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis. Development 120: 177-187.
35. PERALTA SOLER, A. and KNUDSEN, K.A. (1994). N-cadherin involvement in cardiac myocyte interaction and myofibrillogenesis Dev. Biol. 162: 9-17
36. RADICE, G.L, RAYBURN, H., MATSUNAMI, H., KNUDSEN, K A,TAKEICHI, M. and HYNES, R O. (1997). Developmental defects in mouse embryos lacking N-cadherin. Dev. Biol. 181: 64-78.
37. RANSCHT, B. (1994). Cadherins and catenins: interactions and functions in embryonic development. Curr Opin. Cell Biol. 6: 740-746.
38. REDIES, C. and TAKEICHI, M. (1993). Expression of N-cadherin mRNA during development of the mouse brain. Dev Dynamics 197: 26-39.
39. SHI, S-R, KEY, M.E. and KALRA, K.L. (1991). Antigen retrieval in formalin-fixed paraffin-embedded tissues an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem. 39: 741-748.
40. TAKEICHI, M (1988) The cadherins: cell-cell adhesion molecules controlling animal morphogenesis Development 102: 639-655.
41. TAKEICHI, M. (1990). Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem 59: 237-252.
42. TAKEICHI, M. (1991). Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451-1455.
43. TENNYSON, V.M , GERSHON, M.D., SHERMAN, D.L., BEHRINGER, R.R., RAZ, R , CROTTY, D.A. and WOLGEMUTH, D.J. (1993). Structural abnormalities associated with congenital megacolon in transgenic mice that overexpress the Hoxa-4 gene. Dev. Dynamics 198: 28-53
44. VLEMINCKX, K., VAKAET Jr, L., MAREEL, M., FIERS, W. and VAN ROY, F. (1991). Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107-119
45. WOLGEMUTH, D J., BEHRINGER, R.R., MOSTOLLER, M.P., BRINSTER, R.L. and PALMITER, R D. (1989) Transgenic mice overexpressing the mouse homeobox-containing gene Hox-1 4 exhibit abnormal gut development. Nature 337: 464-467
46. YOKOUCHI, Y., NAKAZATO, S , YAMAMATO, M., GOTO, Y , KAMEDA, T., IBA, H. and KUROIWA, A. (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9: 2509-2522.