Efficacies of atropine/2-PAM and atropine/HI-6 in treating monkeys intoxicated with organophosphonate nerve agents

International Journal of Toxicology

Volumn 16, Issue 1, 1997, Pages 9-20

  Olson, C T ^a   Menton, R G ^a   Kiser, R C ^a   Matthews, M C ^a   Stotts, R R ^b   Romano, J R ^b   Koplovitz, I ^b   Hackley, B E ^b   Johnson, J B ^a  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

2 PAM; Atropine; HI 6; Monkeys; Nerve agents; Organophosphates

Indexed keywords

ATROPINE; ORGANOPHOSPHATE INSECTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; GOOD LABORATORY PRACTICE; INTOXICATION; LETHALITY; MONKEY; NONHUMAN; PROTECTION; STATISTICAL ANALYSIS;

ANIMALIA; MACACA MULATTA;

EID: 0030738876     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158197227314     Document Type: Article

References (8)

1. Feder, P. I., Hobson, D. W., Olson, C. T., Joiner, R. L., and Matthews, M. C. 1991a. Stagewise, adaptive dose allocation for quantal response dose - response studies. Neurosci. Biobehav. Rev. 15:109-1114.
2. Feder P. I., Olson, C. T., Hobson, D. W., Matthews, M. C., and Joiner, R. L. 1991b. Stagewise, group sequential experimental designs for quantal responses: one-sample and two-sample comparisons. Neurosci. Biobehav. Rev. 15:129-133.
3. Feder, P. I., Olson, C. T., Hobson, D. W., Matthews, M. C., and Joiner, R. L. 1991c. Statistical analysis of dose - response experiments by maximum like-lihood analysis and iteratively reweighted nonlinear least squares regression techniques. Drug Inform. J. 25:323-334.
4. Feder, P. I., Hobson, D. W., Olson, C. T., Joiner, R. L., and Matthews, M. C. 1992a. Statistical design considerations for Stagewise, adaptive dose allocation in dose - response studies. In Biopharmaceutical sequential statistical applications, ed. K. E. Peace. New York: Dekker.
5. Feder, P. I., Olson, C. T., Hobson, D. W., Matthews, M. C., and Joiner, R. L. 1992b. Stagewise, group sequential experimental designs for comparisons of quantal response levels obtained with candidate treatment regimens versus those with a concurrent control or a specified standard. In Biopharmaceutical sequential statistical applications, ed. K. E. Peace. New York: Dekker.
6. Koplovitz I., Gresham, V. C., Dochterman, L. W., Kaminskis, A., and Stewart, J. R. 1992. Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys. Arch. Toxicol. 66:622-628.
7. Olson, C. T., Menton, R. G., Kiser, R. C., Matthews, M. C., Hayes, T. L., Singer, A. W., and Dill, G. S. 1991. Battelle Final Report on Task 89-12: Characterization of soman toxicity in atropine and oxime (HI-6 and MMB-4) treated rhesus monkeys. Submitted to U.S. Army Medical Research and Development Command.
8. 50 soman and treated with atropine/2-PAM. Submitted to U.S. Army Medical Research and Materiel Command.