Activity-dependent survival of rat cerebellar granule neurons is not associated with sustained elevation of intracellular Ca2+

Neuroscience Letters

Volumn 228, Issue 2, 1997, Pages 123-126

  Ono, Tomio ^a   Kudo, Yoshihisa ^b   Kohara, Keigo ^c   Kawashima, Seiichi ^a   Ogura, Akihiko ^c  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Activity dependent survival; Apoptosis; Ca2+ set point hypothesis; Ca2+ turn over hypothesis; Cerebellar granule neurons; Neuronal plasticity

Indexed keywords

ALCOHOL; CALCIUM ION; IONOMYCIN; NIFEDIPINE; POTASSIUM CHLORIDE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; DIAGNOSIS; GRANULE CELL; INTRACELLULAR TRANSPORT; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; VOLTAGE CLAMP;

ANIMALS; APOPTOSIS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; ELECTROPHYSIOLOGY; IONOMYCIN; IONOPHORES; MEMBRANE POTENTIALS; NEURONAL PLASTICITY; NEURONS; NIFEDIPINE; POTASSIUM CHLORIDE; RATS;

EID: 0030738070     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00383-2     Document Type: Article

References (16)

1. Balázs R., Jørgensen O.S., Hack N. N-Methyl-D-aspartate promotes the survival of cerebellar granule cells in primary culture. Neuroscience. 27:1988;437-451.
2. Bambrick L.L., Yarowsky P.J., Krueger B.K. Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse. Proc. Natl. Acad. Sci. USA. 92:1995;9692-9696.
3. Flanklin J.F., Johnson E.M. Jr. Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium. Trends Neurosci. 15:1992;501-508.
4. 2+ influx but not Trk activation. J. Neurosci. 15:1995;643-664.
5. Forti L., Tottene A., Moretti A., Pietrobon D. Three novel types of voltage-dependent calcium channels in rat cerebellar neurons. J. Neurosci. 14:1994;5243-5256.
6. Gallo V., Kingsbury A., Balázs R., Jørgensen O.S. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7:1987;2203-2213.
7. Ghosh A., Carnahan J., Greengard M.E. Requirement for BDNF in activity-dependent survival of cortical neurons. Science. 263:1994;1618-1623.
8. Klein R. Roles of neurotrophins in mouse neuronal development. FASEB J. 8:1994;738-744.
9. 2+ determine nerve growth factor dependence of sympathetic ganglion cells. Proc. Natl. Acad. Sci. USA. 86:1989;6421-6425.
10. Kudo Y., Nakamura K., Sugaya K., Noguchi K., Iijima T., Ogura A. Characteristics of the changes in intracellular calcium concentration on the activation of muscarinic receptors in hippocampal neurons. Prog. Brain Res. 98:1993;323-331.
11. Lauder J.M. Neurotransmitter as growth regulatory signals: role of receptors and second messengers. Trends Neurosci. 16:1993;233-240.
12. Levi, G., Aloisi, F., Ciotti, M.T., Thangnipon, W., Kingsburry, A. and Balazs, R., Preparation of 98% pure cerebellar granule cell cultures. In A. Shahar, J. Vellis and B.A. Habu (Eds.), Dissection and Tissue Culture Manual of the Nervous system, Alan R. Liss, New York, 1989, pp. 211-214.
13. Mosmann T. Rapid calorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
14. Ono, T., Inokuchi, K., Ogura, A., Ikawa, Y., Kudo, Y. and Kawashima, S., Activity-dependent expression of parathyroid hormone-related protein (PTHrP) in rat cerebellar granule neurons: requirement of PTHrP for the activity-dependent survival of granule neurons, J. Biol. Chem., 272 (1997) in press.
15. Oppenheim R.W. Cell death during development of nervous system. Annu. Rev. Neurosci. 14:1991;453-501.
16. Yan G.-M., Ni B., Weller M., Wood K.A., Paul S.M. Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res. 656:1994;43-51.