Synthesis of oligonucleotide derivatives containing pyrene labeled glycerol linkers : Enhanced excimer fluorescence on binding to a complementary DNA sequence

Tetrahedron Letters

Volumn 38, Issue 34, 1997, Pages 6051-6054

  Yamana, Kazushige ^a   Takei, Mizuki ^a   Nakano, Hidehiko ^a  

^a UNIVERSITY OF HYOGO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE;

ARTICLE; DNA BINDING; DNA HYBRIDIZATION; DRUG SYNTHESIS; FLUORESCENCE;

EID: 0030738043     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01358-0     Document Type: Article

References (25)

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20. 2O), 8.04-8.47 (9H, m, aromatic of pyrene).
21. 2O-), 7.05-7.32 (13H, m, aromatic of DMT), 8.03-8.50 (9H, m, aromatic of pyrene).
22. Atkinson, T.; Smith, M. Oligonucleotide Synthesis: A Practical Approach 1984; Gait, M.J., Ed.; IRL Press, Oxford, UK; pp 35-81.
23. Yamana, K.; Mitsui, T.; Yoshioka.J.; Isuno.T.; Nakano, H. Bioconjugate Chem. 1996, 7, 715-720.
24. The TOP Mass spectra were obtained on a Bruker ReflexII model using a negative linear mode. Oligomerl : 5172.0 (calcd.5172.5), oligomer 2 : 5540.0 (calcd.5540.8).
25. -5 M.