Elimination of T-cell-receptor/β-chain diversity in transgenic mice restricts antigen-specific but not alloreactive responses

Immunology

Volumn 91, Issue 3, 1997, Pages 375-382

  O'Brien, D P ^a   Baecher Allan, C M ^a   Burns Jr , R P ^a   Shastri, N ^b   Barth, R K ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; BETA CHAIN; BIODIVERSITY; GENE FREQUENCY; GENE REARRANGEMENT; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; T LYMPHOCYTE RECEPTOR GENE;

EID: 0030737606     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00281.x     Document Type: Article

References (42)

1. MCINTYRE B.W. & ALLISON J. (1983) The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides. Cell 34, 739.
2. KAPPLER J., KUBO R., HASKINS K et al. (1983) The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides. Cell 35, 295.
3. MEUER S.C., ACUTO O., HERCEND T., SCHLOSSMAN S.F. & REINHERZ E.L. (1984) The human T-cell receptor. Annu Rev Immunol 2, 23.
4. DEMBIC Z., HAAS W., WEISS S. et al. (1986) Transfer of specificity by murine α and β T-cell receptor genes. Nature 320, 232.
5. SAITO T. & GERMAIN R.N. (1987) Predictable acquisition of a new MHC recognition specificity following expression of a transfected T-cell receptor β-chain gene. Nature 329, 256.
6. UEMATSU Y., RYSER S., DEMBIC Z. et al. (1988) In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52, 831.
7. BERG L.J.. DE ST. GROTH B.F., Ivars F. et al. (1988) Expression of T-cell receptor α-chain genes in transgenic mice. Mol Cell Biol 8, 5459.
8. FENTON R.G., MARRACK P., KAPPLER J.W., KANAGAWA O. & SEIDMAN J.G. (1988) Isotypic exclusion of γδ T cell receptors in transgenic mice bearing a rearranged β-chain gene. Science 241, 1089.
9. SHASTRI N., GAMMON G., MILLER A. & SERCARZ E.E. (1986) Ia molecule-associated selectivity in T cell recognition of a 23-amino-acid peptide of lysozyme. J Exp Med 164, 882.
10. WYSOCKI L.J. & SATO V.L. (1978) 'Panning' for lymphocytes: a method for cell selection. Proc Natl Acad Sci 75, 2844.
11. HAMANN U., EICHMANN K. & KRAMMER P.H. (1983) Frequencies and regulation of trinitrophenyl-specific cytotoxic T precursor cells: immunization results in release from suppression. J Immunol 130, 7.
12. GEBEL H.M., SCOTT J.R., PARVIN C.A. & RODEY G.E. (1983) In vitro immunization to KLH. II. Limiting dilution analysis of antigen-reactive cells in primary and secondary culture. J Immunol 130, 29.
13. SHARROCK C.E.M., KAMINSKI E. & MAN S. (1990) Limiting dilution analysis of human T cells: a useful clinical tool. Immunol Today 11, 281.
14. FAZEKAS DE St. GROTH S. (1982) The evaluation of limiting dilution assays. J Immunol Methods 49, 11.
15. MEO T. (1979) The MLR Test in the Mouse. In: Immunological Methods, Vol. 1, p. 227.
16. GAMMON G., SHASTRI N., COGSWELL J. et al. (1987) The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at, the determinant site. Immunol Rev 98, 53.
17. BRETT S.J.. CEASE K.B. & BERZOFSKY J.A. (1988) Influences of antigen processing on the expression of the T cell repertoire. Evidence for MHC-specific hindering structures on the products of processing. J Exp Med 168, 357.
18. HANNUM C., ULTEE M., MATIS L.A., SCHWARTZ R.H. & MARGOLIASH E. (1982) The major B and T cell determinant on pigeon cytochrome c in B10.A mice. Adv Exp Med Biol 150, 37.
19. VORDERMEIER H.M., HARRIS D.P., ROMAN E., LATHIGRA R., MORENO C. & IVANYI J. (1991) Identification of T cell stimulatory peptides from the 38-kDa protein of Mycobacterium tuberculosis. J Immunol 147, 1023.
20. BRANDLE D., BURKE K., WALLACE V.A. et al. (1991) Involvement of both T cell receptor Vα and Vβ variable region domains and α chain junctional region in viral antigen recognition. Eur J Immunol 21 ,2195.
21. b-restricted. TNP-specific cytolytic T cell clone. Eur J Immunol 22, 335.
22. b recognition. J Immunol 152, 1790.
23. JORGENSEN J.L., ESSER U., DE ST GROTH B.F., REAY P.A. & DAVIS M.M. (1992) Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355, 224.
24. SADLACK B., MERZ H., SCHORLE H., SCHIMPL A., FELLER A.C. & HORAK I. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75, 253.
25. KUHN R., LOHLER J., RENNICK D., RAJEWSKY K. & MULLER W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis, Cell. 75, 263.
26. MOMBAERTS P., MIZOGUCHI E., GRUSBY M.J., GLIMCHER L.H., BHAN A.K. & TONEGAWA S. (1993) Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75, 275.
27. + responses in mice transgenic for a T-cell receptor β chain selected at random. J Virol 68, 3065.
28. DOHERTY P.C., HOU S., EVANS C.F., WHITTON J.L., OLDSTONE M.B.A. & BLACKMAN M.A. (1994) Limiting the available T-cell receptor repertoire modifies acute lymphocytic choriomeningitis virus- induced immunopathology. J Neuroimmunol 51, 147.
29. KUCHEROO V.K., COLLINS M., AL-SABBAGH A. et al. (1994) T-cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR Vβ8,2 transgenic mice. J Exp Med 179, 1659.
30. JONES G. (1973) The number of reactive cells in mouse lymphocyte cultures stimulated by phytohemagglutinin, concanavalin A or histocompatibility antigen. J Immunol 111, 914.
31. SHERMAN L.A. (1982) Recognition of conformational determinants on H-2 by cytolytic T lymphocytes. Nature 297, 511.
32. ELLIOT T.J. & EISEN H.N. (1990) Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc Natl Acad Sci USA 87, 5213.
33. BLUESTONE J.A., KALIYAPERUMAL A., JAMESON S., MILLER S. & DICK R. (1993) Peptide-induced changes in class I heavy chains alter allorecognition. J Immunol 151, 3943.
34. ALEXANDER-MILLER M.A., BURKE K., KOSZINOWSKI U.H., HANSEN T.H. & CONNOLLY J.M. (1993) Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity. J Immunol 151, 1.
35. CHATTOPADHYAY S., THEOBALD M., BIGGS J. & SHERMAN L.A. (1994) Conformational differences in major histocompatibility complex-peptide complexes can result in alloreactivity Exp Med 179, 213.
36. MULLBACHER A., HILL A.B., BLANDEN R.V., COWDEN W.B., KING J.J.C. & HLA R.T. (1991) Alloreactive cytotoxic T cells recognize MHC class I antigen without peptide specificity. J Immunol 47, 1765.
37. LJUNGGREN H.G., STAM N.J., OHLEN C. et al. (1990) Empty MHC class I molecules come out in the cold. Nature 346, 476.
38. + T cell selection in mice lacking invariant chain expression. J Exp Med 177, 1699.
39. BARRETT L.V., RIMM I.J., WIENS G.R., SEIDMAN J.G. & KIRKMAN R.L. (1991) Allorecognition in T-cell receptor (beta-chain) transgenic mice. Surgery. 110, 385.
40. DAVIS M.M. & BJORKMAN P.J. (1988) T-cell antigen receptor genes and T-cell recognition. Nature 334, 395.
41. BARTH R.K., KIM B.S., LAN N.C. et al (1985) The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments. Nature 316, 517.
42. BEHLKE M.A., SPINELA D.G., CHOU H., SHA W., HARTL D. & LOH D.Y. (1985) T-cell receptor β-chain expression: dependence on relatively few variable region genes. Science 229, 566.