Metabolism of the intravenously administered recombinant human basic fibroblast growth factor, trafermin, in liver and kidney: Degradation implicated in its selective localization to the fenestrated type microvasculatures

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 7, 1997, Pages 786-793

  Yuge, Takuro ^a   Furukawa, Akihiko ^a   Nakamura, Katsuhiro ^a   Nagashima, Yutaka ^a   Shinozaki, Kohki ^a   Nakamura, Toshiyuki ^a   Kimura, Ryohei ^b  

^a KAKEN PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Internalization; Metabolism; Sinusoidal endothelium; Trafermin

Indexed keywords

DRUG METABOLITE; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; DRUG DISTRIBUTION; DRUG INACTIVATION; DRUG METABOLISM; DRUG PROTEIN BINDING; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT;

EID: 0030737557     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.786     Document Type: Article

References (21)

1. Gospodarowicz D., Nature (London), 249, 123-127 (1974).
2. Gospodarowicz D., J. Biol. Chem., 250, 2515-2520 (1975).
3. Robson M. C., Phillips L. G., Lawrence W. T., Bishop J. B., Youngerman J. S., Hayward P. G., Broemeling L. D., Meggers J. P., Ann. Surg., 216, 401-408 (1992).
4. Ishibashi Y., Soeda S., Ohura T., Nishikawa T., Niimura M., Nakajima H., Mizoguchi M., Shioya N., Tsukada S., Hori Y., Ogawa N., J. Clin. Ther. Med. 12, 2159-2187 (1996).
5. Tanaka E., Ase K., Okuda T., Okumura M., Nogimori K., Biol. Pharm. Bull., 19, 1141-1148 (1996).
6. Fisher M., Meadows M.-E., Do T., Weise J., Trubetskoy V., Charette M., Finklestein S. P., J. Cereb. Blood Fow Metab., 15, 953-959 (1995).
7. Tanaka R., Miyasaka Y., Yada K., Ohwada T., Kameya T., Stroke, 26, 2154-2159 (1995).
8. Yang H. T., Deschenes M. R., Ogilvie R. W., Terjung R. L., Circ. Res., 79, 62-69 (1996).
9. Lazarous D. F., Scheinowitz M., Shou M., Hodge E., Rajanayagam M. A. S., Hunsberger S., Robison G., Jr., Stiber J. A., Correa R., Epstein S. E., Unger E. F., Circulation, 91, 145-153 (1995).
10. Furukawa A., Yuge T., Nakamura K., Nagashima Y., Awaji T., Clin. Rep., 30, 1579-1589 (1996).
11. Kadono T., Kikuchi K., Kubo M., Fujimoto M., Tamaki K., J. Am. Acad. Dermatol., 35, 392-397 (1996).
12. Gospodarowicz D., Ferrera N., Schweigerer L., Neufeld G., Endocrine Rev., 8, 95-114 (1987).
13. Ullberg S., Acta Radiol. Suppl., 118, 1-110 (1954).
14. Laemmli U. K., Nature (London), 227, 680-685 (1970).
15. Hondermarck H., Courty J., Boilly B., Thomas D., Experientia, 46, 973-974 (1990).
16. Moscatelli D., J. Cell Biol., 107, 753-759 (1988).
17. Rusnati M., Urbinati C., Presta M., J. Cell Physiol., 154, 152-161 (1993).
18. Gleizes P.-E., Noaillac-Depeyre J., Amalric F., Gas N., Eur. J. Cell Biol., 66, 47-59 (1995).
19. Patry V., Arnaud E., Amalric F., Prats H., Growth Factors, 11, 163-174 (1994).
20. Hanneken A., Ying W., Ling N., Baird A., Proc. Natl. Acad. Sci. U.S.A., 91, 9170-9174 (1994).
21. Marshall A. C., Bradford C. B., Heart Disease and Stroke, 2, 166-170 (1993).