Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs

European Journal of Medicinal Chemistry

Volumn 32, Issue 10, 1997, Pages 823-831

  Gibson, D ^b   Binyamin, I ^b   Haj, M ^b   Ringel, I ^b   Ramu, A ^a   Katzhendler, J ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b NONE

Author keywords

Anthraquinone; Anticancer; Carrier; Intercalator; Platinum

Indexed keywords

ANTHRAQUINONE; PLATINUM; PLATINUM 1,2 DIAMINOCYCLOHEXANE MALONATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA BINDING; DRUG POTENCY; DRUG SOLUBILITY; HEAD AND NECK CANCER; LEUKEMIA CELL; LIGAND BINDING; NEPHROTOXICITY;

EID: 0030736636     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80068-3     Document Type: Article

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1. Abbreviations: DDP, diamminedichloroplatinum(II); DCC, dicyclohexyl carbodiimide; HOBT, 1-hydroxy-benzotriazole-hydrate; DCU, dicylclohexylurea; BOC, -t-butoxycarbonyl; DACH, (+/-)c/s-1,2-diaminocyclohexane; CHA, cyclohexylamine; TFA, trifluoroacetic acid.
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